Author results

2LZ3
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SOLUTION NMR STRUCTURE OF TRANSMEMBRANE DOMAIN OF AMYLOID PRECURSOR PROTEIN WT
分子名称:Amyloid beta A4 protein
著者Chen, W., Wang, C.
登録日2012-09-23
公開日2013-10-02
最終更新日2016-04-27
実験手法SOLUTION NMR
主引用文献Familial Alzheimer's mutations within APPTM increase A beta 42 production by enhancing accessibility of epsilon-cleavage site.
Nat Commun, 5, 2014
2LZ4
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SOLUTION NMR STRUCTURE OF TRANSMEMBRANE DOMAIN OF AMYLOID PRECURSOR PROTEIN V44M
分子名称:Amyloid beta A4 protein
著者Chen, W., Wang, C.
登録日2012-09-23
公開日2013-10-02
最終更新日2016-04-27
実験手法SOLUTION NMR
主引用文献Familial Alzheimer's mutations within APPTM increase A beta 42 production by enhancing accessibility of epsilon-cleavage site.
Nat Commun, 5, 2014
3DSH
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CRYSTAL STRUCTURE OF DIMERIC INTERFERON REGULATORY FACTOR 5 (IRF-5) TRANSACTIVATION DOMAIN
分子名称:Interferon regulatory factor 5
著者Chen, W., Lam, S.S., Srinath, H., Jiang, Z., Correia, J.J., Schiffer, C., Fitzgerald, K.A., Lin, K., Royer Jr., W.E.
登録日2008-07-12
公開日2008-10-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5.
Nat.Struct.Mol.Biol., 15, 2008
3GBL
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CRYSTAL STRUCTURE OF GRASS CARP BETA2-MICROGLOBULIN
分子名称:Beta2-microglobulin
著者Chen, W., Gao, F., Xia, C., Gao, G.F.
登録日2009-02-20
公開日2010-03-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of grass carp Beta2-microglobulin
To be Published
5HZQ
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CRYSTAL STRUCTURE OF CELLULAR RETINOIC ACID BINDING PROTEIN 2 (CRABP2)-ARYL FLUOROSULFATE COVALENT CONJUGATE
分子名称:Cellular retinoic acid-binding protein 2, 4'-[(3,6,9,12-tetraoxapentadec-14-yn-1-yl)oxy][1,1'-biphenyl]-4-yl sulfurofluoridate, GLYCEROL
著者Chen, W., Mortenson, D.E., Wilson, I.A., Kelly, J.W.
登録日2016-02-02
公開日2016-06-01
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue.
J.Am.Chem.Soc., 138, 2016
5Y29
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CRYSTAL STRUCTURE OF OSTRINIA FURNACALIS GROUP II CHITINASE CATALYTIC DOMAIN 1
分子名称:insect group II chitinase, 2-acetamido-2-deoxy-beta-D-glucopyranose
著者Chen, W., Qu, M.B., Zhou, Y., Yang, Q.
登録日2017-07-24
公開日2018-01-17
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural analysis of group II chitinase (ChtII) catalysis completes the puzzle of chitin hydrolysis in insects
J. Biol. Chem., 293, 2018
5Y2A
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CRYSTAL STRUCTURE OF OSTRINIA FURNACALIS GROUP II CHITINASE CATALYTIC DOMAIN 2
分子名称:insect group II chitinase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Chen, W., Qu, M.B., Zhou, Y., Yang, Q.
登録日2017-07-24
公開日2018-01-17
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural analysis of group II chitinase (ChtII) catalysis completes the puzzle of chitin hydrolysis in insects
J. Biol. Chem., 293, 2018
5Y2B
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CRYSTAL STRUCTURE OF OSTRINIA FURNACALIS GROUP II CHITINASE CATALYTIC DOMAIN 1 IN COMPLEX WITH HEPTA-N-ACETYLCHITOOCTAOSE (NAG)7
分子名称:insect group II chitinase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose
著者Chen, W., Qu, M.B., Zhou, Y., Yang, Q.
登録日2017-07-24
公開日2018-01-17
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural analysis of group II chitinase (ChtII) catalysis completes the puzzle of chitin hydrolysis in insects
J. Biol. Chem., 293, 2018
5Y2C
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CRYSTAL STRUCTURE OF OSTRINIA FURNACALIS GROUP II CHITINASE CATALYTIC DOMAIN 2 E2180L MUTANT IN COMPLEX WITH PENTA-N-ACETYLCHITOOCTAOSE (NAG)5
分子名称:insect group II chitinase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Chen, W., Qu, M.B., Zhou, Y., Yang, Q.
登録日2017-07-24
公開日2018-01-17
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structural analysis of group II chitinase (ChtII) catalysis completes the puzzle of chitin hydrolysis in insects
J. Biol. Chem., 293, 2018
6JAV
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CRYSTAL STRUCTURE OF OSTRINIA FURNACALIS GROUP II CHITINASE CATALYTIC DOMAIN 1 IN COMPLEX WITH A PIPERIDINE-THIENOPYRIDINE DERIVATIVE
分子名称:Group II chitinase, 2-{[(4-chlorophenyl)methyl]sulfanyl}-7-methyl-N-(prop-2-en-1-yl)-7,8-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose
著者Chen, W., Zhou, Y., Yang, Q.
登録日2019-01-25
公開日2019-05-15
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.437 Å)
主引用文献Structural dissection reveals a general mechanistic principle for group II chitinase (ChtII) inhibition.
J.Biol.Chem., 294, 2019
6JAW
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CRYSTAL STRUCTURE OF OSTRINIA FURNACALIS GROUP II CHITINASE CATALYTIC DOMAIN 1 IN COMPLEX WITH A NAPTHALIMIDE DERIVATIVE
分子名称:Group II chitinase, 2-[3-(morpholin-4-yl)propyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose
著者Chen, W., Zhou, Y., Yang, Q.
登録日2019-01-25
公開日2019-05-15
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.981 Å)
主引用文献Structural dissection reveals a general mechanistic principle for group II chitinase (ChtII) inhibition.
J.Biol.Chem., 294, 2019
6JAX
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CRYSTAL STRUCTURE OF OSTRINIA FURNACALIS GROUP II CHITINASE CATALYTIC DOMAIN 1 IN COMPLEX WITH CHITOOCTAOSE [(GLCN)8]
分子名称:Group II chitinase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose
著者Chen, W., Zhou, Y., Yang, Q.
登録日2019-01-25
公開日2019-05-15
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural dissection reveals a general mechanistic principle for group II chitinase (ChtII) inhibition.
J.Biol.Chem., 294, 2019
6JAY
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CRYSTAL STRUCTURE OF OSTRINIA FURNACALIS GROUP II CHITINASE CATALYTIC DOMAIN 1 IN COMPLEX WITH A DIPYRIDO-PYRIMIDINE DERIVATIVE
分子名称:Group II chitinase, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-1-[(furan-2-yl)methyl]-5-oxo-3-({[(2S)-oxolan-2-yl]methyl}carbamoyl)-5H-dipyrido[1,2-a:2',3'-d]pyrimidin-1-ium
著者Chen, W., Zhou, Y., Yang, Q.
登録日2019-01-25
公開日2019-05-15
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.498 Å)
主引用文献Structural dissection reveals a general mechanistic principle for group II chitinase (ChtII) inhibition.
J.Biol.Chem., 294, 2019
6K3Z
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CRYSTAL STRUCTURE OF DCAS9 IN COMPLEX WITH SGRNA AND DNA (TGA PAM)
分子名称:RNA (81-MER), CRISPR-associated endonuclease Cas9, DNA (28-MER), ...
著者Chen, W., Zhang, H., Zhang, Y., Wang, Y., Gan, J., Ji, Q.
登録日2019-05-22
公開日2019-09-25
最終更新日2019-11-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
6K4P
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CRYSTAL STRUCTURE OF XCAS9 IN COMPLEX WITH SGRNA AND DNA (TGG PAM)
分子名称:sgRNA, DNA (28-MER), non-targeted DNA, ...
著者Chen, W., Zhang, H., Zhang, Y., Wang, Y., Gan, J., Ji, Q.
登録日2019-05-25
公開日2019-09-25
最終更新日2019-11-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
6K4Q
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CRYSTAL STRUCTURE OF XCAS9 IN COMPLEX WITH SGRNA AND DNA (CGG PAM)
分子名称:sgRNA, DNA (28-MER), DNA (5'-D(*AP*AP*AP*CP*GP*GP*TP*AP*TP*TP*G)-3'), ...
著者Chen, W., Zhang, H., Zhang, Y., Wang, Y., Gan, J., Ji, Q.
登録日2019-05-26
公開日2019-09-25
最終更新日2019-11-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
6K4S
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CRYSTAL STRUCTURE OF XCAS9 IN COMPLEX WITH SGRNA AND DNA (TGC PAM)
分子名称:CRISPR-associated endonuclease Cas9/Csn1, sgRNA, targeted DNA, ...
著者Chen, W., Zhang, H., Zhang, Y., Wang, Y., Gan, J., Ji, Q.
登録日2019-05-26
公開日2019-09-25
最終更新日2019-11-13
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
6K4U
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CRYSTAL STRUCTURE OF XCAS9 IN COMPLEX WITH SGRNA AND DNA (TGA PAM)
分子名称:CRISPR-associated endonuclease Cas9, sgRNA, target DNA, ...
著者Chen, W., Zhang, H., Zhang, Y., Wang, Y., Gan, J., Ji, Q.
登録日2019-05-27
公開日2019-09-25
最終更新日2019-11-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
6K57
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CRYSTAL STRUCTURE OF DCAS9 IN COMPLEX WITH SGRNA AND DNA (CGA PAM)
分子名称:sgRNA, CRISPR-associated endonuclease Cas9, target DNA, ...
著者Chen, W., Zhang, H., Zhang, Y., Wang, Y., Gan, J., Ji, Q.
登録日2019-05-28
公開日2019-09-25
最終更新日2019-11-13
実験手法X-RAY DIFFRACTION (2.98 Å)
主引用文献Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
4NPL
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CRYSTAL STRUCTURE OF ZEBRAFISH ALKBH5 IN COMPLEX WITH ALPHA-KETOGLUTARATE
分子名称:RNA demethylase ALKBH5, MANGANESE (II) ION, 2-OXOGLUTARIC ACID
著者He, C., Chen, W., Zhang, L.
登録日2013-11-21
公開日2014-02-19
最終更新日2014-04-02
実験手法X-RAY DIFFRACTION (1.651 Å)
主引用文献Crystal structure of the RNA demethylase ALKBH5 from zebrafish.
Febs Lett., 588, 2014
4NPM
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CRYSTAL STRUCTURE OF ZEBRAFISH ALKBH5 IN COMPLEX WITH SUCCINIC ACID
分子名称:RNA demethylase ALKBH5, MANGANESE (II) ION, SUCCINIC ACID
著者He, C., Chen, W., Zhang, L.
登録日2013-11-21
公開日2014-02-19
最終更新日2014-04-02
実験手法X-RAY DIFFRACTION (1.803 Å)
主引用文献Crystal structure of the RNA demethylase ALKBH5 from zebrafish.
Febs Lett., 588, 2014
2M9E
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NMR SOLUTION STRUCTURE OF PIN1 WW DOMAIN MUTANT 5-1
分子名称:Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
著者Enck, S., Chen, W., Price, J.L., Powers, E.T., Wong, C., Dyson, H.J., Kelly, J.W.
登録日2013-06-07
公開日2013-06-26
最終更新日2013-07-17
実験手法SOLUTION NMR
主引用文献Structural and energetic basis of carbohydrate-aromatic packing interactions in proteins.
J.Am.Chem.Soc., 135, 2013
2M9F
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NMR SOLUTION STRUCTURE OF PIN1 WW DOMAIN MUTANT 5-1G
分子名称:Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, 2-acetamido-2-deoxy-beta-D-glucopyranose
著者Enck, S., Chen, W., Price, J.L., Powers, E.T., Wong, C., Dyson, H.J., Kelly, J.W.
登録日2013-06-07
公開日2013-06-26
最終更新日2020-07-29
実験手法SOLUTION NMR
主引用文献Structural and energetic basis of carbohydrate-aromatic packing interactions in proteins.
J.Am.Chem.Soc., 135, 2013
2M9I
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NMR SOLUTION STRUCTURE OF PIN1 WW DOMAIN VARIANT 6-1
分子名称:Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
著者Enck, S., Chen, W., Price, J.L., Powers, E.T., Wong, C., Dyson, H.J., Kelly, J.W.
登録日2013-06-10
公開日2013-06-26
最終更新日2013-07-17
実験手法SOLUTION NMR
主引用文献Structural and energetic basis of carbohydrate-aromatic packing interactions in proteins.
J.Am.Chem.Soc., 135, 2013
2M9J
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NMR SOLUTION STRUCTURE OF PIN1 WW DOMAIN MUTANT 6-1G
分子名称:Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, 2-acetamido-2-deoxy-beta-D-glucopyranose
著者Enck, S., Chen, W., Price, J.L., Powers, E.T., Wong, C., Dyson, H.J., Kelly, J.W.
登録日2013-06-10
公開日2013-06-26
最終更新日2020-07-29
実験手法SOLUTION NMR
主引用文献Structural and energetic basis of carbohydrate-aromatic packing interactions in proteins.
J.Am.Chem.Soc., 135, 2013
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件を2020-08-05に公開中