Author results

6IIJ
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CRYO-EM STRUCTURE OF CV-A10 MATURE VIRION
分子名称:VP1, VP2, VP3, ...
著者Chen, J.H., Ye, X.H., Cong, Y., Huang, Z.
登録日2018-10-06
公開日2018-11-07
実験手法ELECTRON MICROSCOPY (2.84 Å)
主引用文献Structure of CVA10 mature virion
To Be Published
6IIO
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CRYO-EM STRUCTURE OF CV-A10 NATIVE EMPTY PARTICLE
分子名称:VP1, VP0, VP3
著者Chen, J.H., Ye, X.H., Cong, Y., Huang, Z.
登録日2018-10-07
公開日2018-11-07
実験手法ELECTRON MICROSCOPY (3.12 Å)
主引用文献Structure of CVA10 native empty particle
To Be Published
5F2E
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CRYSTAL STRUCTURE OF SMALL MOLECULE ARS-853 COVALENTLY BOUND TO K-RAS G12C
分子名称:GTPase KRas, MAGNESIUM ION, GLYCEROL, ...
著者Patricelli, M.P., Janes, M.R., Li, L.-S., Hansen, R., Peters, U., Kessler, L.V., Chen, Y., Kucharski, J.M., Feng, J., Ely, T., Chen, J.H., Firdaus, S.J., Babbar, A., Ren, P., Liu, Y.
登録日2015-12-01
公開日2016-01-13
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State.
Cancer Discov, 6, 2016
5V9U
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CRYSTAL STRUCTURE OF SMALL MOLECULE ARS-1620 COVALENTLY BOUND TO K-RAS G12C
分子名称:GTPase KRas, CALCIUM ION, (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one, ...
著者Janes, M.R., Zhang, J., Li, L.-S., Hansen, R., Peters, U., Guo, X., Chen, Y., Babbar, A., Firdaus, S.J., Feng, J., Chen, J.H., Li, S., Brehmer, D., Darjania, L., Li, S., Long, Y.O., Thach, C., Liu, Y., Zarieh, A., Ely, T., Kucharski, J.M., Kessler, L.V., Wu, T., Wang, Y., Yao, Y., Deng, X., Zarrinkar, P., Dashyant, D., Lorenzi, M.V., Hu-Lowe, D., Patricelli, M.P., Ren, P., Liu, Y.
登録日2017-03-23
公開日2018-02-07
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor.
Cell, 172, 2018
3SJM
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CRYSTAL STRUCTURE ANALYSIS OF TRF2-DBD-DNA COMPLEX
分子名称:DNA (5'-D(*CP*TP*CP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*CP*CP*CP*TP*AP*AP*CP*CP*CP*TP*AP*GP*A)-3'), Telomeric repeat-binding factor 2
著者Nair, S.K., Sliverman, S.K., Chen, J.H., Xiao, Y.
登録日2011-06-21
公開日2012-10-31
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Crystal Structure Analysis of TRF2-Dbd-DNA complex
To be Published
3NKB
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A 1.9A CRYSTAL STRUCTURE OF THE HDV RIBOZYME PRECLEAVAGE SUGGESTS BOTH LEWIS ACID AND GENERAL ACID MECHANISMS CONTRIBUTE TO PHOSPHODIESTER CLEAVAGE
分子名称:DNA/RNA (5'-D(*(DUR))-D(*GP*G)-R(P*CP*UP*UP*GP*CP*A)-3'), The hepatitis delta virus ribozyme, MAGNESIUM ION
著者Chen, J.-H., Yajima, R., Chadalavada, D.M., Chase, E., Bevilacqua, P.C., Golden, B.L.
登録日2010-06-18
公開日2010-09-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.916 Å)
主引用文献A 1.9 A crystal structure of the HDV ribozyme precleavage suggests both Lewis acid and general acid mechanisms contribute to phosphodiester cleavage.
Biochemistry, 49, 2010
5ZE8
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CRYSTAL STRUCTURE OF A PENTA-HEME CYTOCHROME C552 FROM THERMOCHROMATIUM TEPIDUM
分子名称:cytochrome c552, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ...
著者Yu, L.-J., Chen, J.-H., Shen, J.-R.
登録日2018-02-27
公開日2018-04-25
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Properties and structure of a low-potential, penta-heme cytochrome c552from a thermophilic purple sulfur photosynthetic bacterium Thermochromatium tepidum.
Photosyn. Res., 139, 2019
2RKJ
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COCRYSTAL STRUCTURE OF A TYROSYL-TRNA SYNTHETASE SPLICING FACTOR WITH A GROUP I INTRON RNA
分子名称:RNA (238-MER), RNA (5'-R(P*GP*CP*UP*U)-3'), Tyrosyl-tRNA synthetase
著者Paukstelis, P.J., Chen, J.-H., Chase, E., Lambowitz, A.M., Golden, B.L.
登録日2007-10-16
公開日2008-01-08
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (4.5 Å)
主引用文献Structure of a tyrosyl-tRNA synthetase splicing factor bound to a group I intron RNA.
Nature, 451, 2008
3K53
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CRYSTAL STRUCTURE OF NFEOB FROM P. FURIOSUS
分子名称:Ferrous iron transport protein b
著者Eng, E.T., Dong, G., Unger, V.M.
登録日2009-10-06
公開日2010-05-26
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural fold, conservation and Fe(II) binding of the intracellular domain of prokaryote FeoB.
J.Struct.Biol., 170, 2010
3OOL
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I-SCEI COMPLEXED WITH C/G+4 DNA SUBSTRATE
分子名称:Intron encoded endonuclease I-SceI, 5'-D(*CP*AP*CP*GP*CP*TP*AP*GP*GP*GP*AP*TP*AP*AP*CP*CP*GP*GP*GP*TP*AP*AP*TP*AP*C)-3', 5'-D(*GP*GP*TP*AP*TP*TP*AP*CP*CP*CP*GP*GP*TP*TP*AP*TP*CP*CP*CP*TP*AP*GP*CP*GP*T)-3', ...
著者Joshi, R., Chen, J.-H., Golden, B.L., Gimble, F.S.
登録日2010-08-31
公開日2010-11-17
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Evolution of I-SceI Homing Endonucleases with Increased DNA Recognition Site Specificity.
J.Mol.Biol., 405, 2011
3OOR
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I-SCEI MUTANT (K86R/G100T)COMPLEXED WITH C/G+4 DNA SUBSTRATE
分子名称:Intron encoded endonuclease I-SceI, 5'-D(*CP*AP*CP*GP*CP*TP*AP*GP*GP*GP*AP*TP*AP*AP*CP*CP*GP*GP*GP*TP*AP*AP*TP*AP*C)-3', 5'-D(*GP*GP*TP*AP*TP*TP*AP*CP*CP*CP*GP*GP*TP*TP*AP*TP*CP*CP*CP*TP*AP*GP*CP*GP*T)-3', ...
著者Joshi, R., Chen, J.-H., Golden, B.L., Gimble, F.S.
登録日2010-08-31
公開日2010-11-17
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Evolution of I-SceI Homing Endonucleases with Increased DNA Recognition Site Specificity.
J.Mol.Biol., 405, 2011
4ETX
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CRYSTAL STRUCTURE OF PELD 158-CT FROM PSEUDOMONAS AERUGINOSA PAO1
分子名称:PelD
著者Li, Z., Chen, J., Nair, S.K.
登録日2012-04-24
公開日2012-07-25
最終更新日2012-09-19
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structures of the PelD Cyclic Diguanylate Effector Involved in Pellicle Formation in Pseudomonas aeruginosa PAO1.
J.Biol.Chem., 287, 2012
4ETZ
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CRYSTAL STRUCTURE OF PELD 158-CT FROM PSEUDOMONAS AERUGINOSA PAO1
分子名称:PelD, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)
著者Li, Z., Chen, J., Nair, S.K.
登録日2012-04-24
公開日2012-07-25
最終更新日2012-09-19
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structures of the PelD Cyclic Diguanylate Effector Involved in Pellicle Formation in Pseudomonas aeruginosa PAO1.
J.Biol.Chem., 287, 2012
4EU0
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CRYSTAL STRUCTURE OF PELD 158-CT FROM PSEUDOMONAS AERUGINOSA PAO1
分子名称:PelD, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)
著者Li, Z., Chen, J., Nair, S.K.
登録日2012-04-24
公開日2012-07-25
最終更新日2012-09-19
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structures of the PelD Cyclic Diguanylate Effector Involved in Pellicle Formation in Pseudomonas aeruginosa PAO1.
J.Biol.Chem., 287, 2012
4EUV
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CRYSTAL STRUCTURE OF PELD 158-CT FROM PSEUDOMONAS AERUGINOSA PAO1, IN COMPLEX WITH C-DI-GMP, FORM 1
分子名称:PelD, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)
著者Li, Z., Chen, J., Nair, S.K.
登録日2012-04-25
公開日2012-07-25
最終更新日2012-09-19
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structures of the PelD Cyclic Diguanylate Effector Involved in Pellicle Formation in Pseudomonas aeruginosa PAO1.
J.Biol.Chem., 287, 2012
4M6B
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CRYSTAL STRUCTURE OF YEAST SWR1-Z DOMAIN IN COMPLEX WITH H2A.Z-H2B DIMER
分子名称:Chimera protein of Histone H2B.1 and Histone H2A.Z, Helicase SWR1
著者Hong, J.J., Feng, H.Q., Wang, F., Ranjan, A., Chen, J.H., Jiang, J.S., Girlando, R., Xiao, T.S., Wu, C., Bai, Y.W.
登録日2013-08-09
公開日2014-02-19
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献The Catalytic Subunit of the SWR1 Remodeler Is a Histone Chaperone for the H2A.Z-H2B Dimer.
Mol.Cell, 53, 2014
3PRE
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QUINAZOLINES WITH INTRA-MOLECULAR HYDROGEN BONDING SCAFFOLD (IMHBS) AS PI3K/MTOR DUAL INHIBITORS.
分子名称:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 2-amino-8-(trans-4-methoxycyclohexyl)-4-methyl-6-(1H-pyrazol-3-yl)pyrido[2,3-d]pyrimidin-7(8H)-one
著者Knighton, D.R., Greasley, S.E., Rodgers, C.M.-L.
登録日2010-11-29
公開日2011-02-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.91 Å)
主引用文献Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
3PRZ
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QUINAZOLINES WITH INTRA-MOLECULAR HYDROGEN BONDING SCAFFOLD (IMHBS) AS PI3K/MTOR DUAL INHIBITORS.
分子名称:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 4-amino-2-methyl-N-(1H-pyrazol-3-yl)quinazoline-8-carboxamide
著者Knighton, D.R., Greasley, S.E., Rodgers, C.M.-L.
登録日2010-11-30
公開日2011-02-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
3PS6
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QUINAZOLINES WITH INTRA-MOLECULAR HYDROGEN BONDING SCAFFOLD (IMHBS) AS PI3K/MTOR DUAL INHIBITORS.
分子名称:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 4-amino-N-(6-methoxypyridin-3-yl)-2-methylquinazoline-8-carboxamide
著者Knighton, D.R., Greasley, S.E., Rogers, C.M.-L.
登録日2010-11-30
公開日2011-02-09
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
4AG8
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CRYSTAL STRUCTURE OF THE VEGFR2 KINASE DOMAIN IN COMPLEX WITH AXITINIB (AG-013736) (N-METHYL-2-(3-((E)-2-PYRIDIN-2-YL-VINYL)-1H- INDAZOL-6-YLSULFANYL)-BENZAMIDE)
分子名称:VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2, AXITINIB
著者McTigue, M., Wickersham, J., Pinko, C., Kania, R.S., Bender, S.
登録日2012-01-24
公開日2012-09-26
最終更新日2017-06-28
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Molecular Conformations, Interactions, and Properties Associated with Drug Efficiency and Clinical Performance Among Vegfr Tk Inhibitors.
Proc.Natl.Acad.Sci.USA, 109, 2012
4AGC
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CRYSTAL STRUCTURE OF VEGFR2 (JUXTAMEMBRANE AND KINASE DOMAINS) IN COMPLEX WITH AXITINIB (AG-013736) (N-METHYL-2-(3-((E)-2-PYRIDIN-2-YL- VINYL)-1H-INDAZOL-6-YLSULFANYL)-BENZAMIDE)
分子名称:VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2, AXITINIB
著者Mctigue, M., Deng, Y., Ryan, K., Brooun, A., Diehl, W., Kania, R.S.
登録日2012-01-26
公開日2012-09-26
最終更新日2012-11-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular Conformations, Interactions, and Properties Associated with Drug Efficiency and Clinical Performance Among Vegfr Tk Inhibitors.
Proc.Natl.Acad.Sci.USA, 109, 2012
4AGD
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CRYSTAL STRUCTURE OF VEGFR2 (JUXTAMEMBRANE AND KINASE DOMAINS) IN COMPLEX WITH SUNITINIB (SU11248) (N-2-DIETHYLAMINOETHYL)-5-((Z)-(5- FLUORO-2-OXO-1H-INDOL-3-YLIDENE)METHYL)-2,4-DIMETHYL-1H-PYRROLE-3- CARBOXAMIDE)
分子名称:VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
著者McTigue, M., Deng, Y., Ryan, K., Brooun, A., Diehl, W., Stewart, A.
登録日2012-01-26
公開日2012-09-26
最終更新日2012-11-14
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Molecular Conformations, Interactions, and Properties Associated with Drug Efficiency and Clinical Performance Among Vegfr Tk Inhibitors.
Proc.Natl.Acad.Sci.USA, 109, 2012
4ASD
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CRYSTAL STRUCTURE OF VEGFR2 (JUXTAMEMBRANE AND KINASE DOMAINS) IN COMPLEX WITH SORAFENIB (BAY 43-9006)
分子名称:VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE
著者McTigue, M., Deng, Y., Ryan, K., Brooun, A., Diehl, W., Stewart, A.
登録日2012-04-30
公開日2012-09-26
最終更新日2012-11-14
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Molecular Conformations, Interactions, and Properties Associated with Drug Efficiency and Clinical Performance Among Vegfr Tk Inhibitors.
Proc.Natl.Acad.Sci.USA, 109, 2012
4ASE
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CRYSTAL STRUCTURE OF VEGFR2 (JUXTAMEMBRANE AND KINASE DOMAINS) IN COMPLEX WITH TIVOZANIB (AV-951)
分子名称:VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2, TIVOZANIB
著者McTigue, M., Deng, Y., Ryan, K., Brooun, A., Diehl, W., Stewart, A.
登録日2012-04-30
公開日2012-09-26
最終更新日2012-11-14
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Molecular Conformations, Interactions, and Properties Associated with Drug Efficiency and Clinical Performance Among Vegfr Tk Inhibitors.
Proc.Natl.Acad.Sci.USA, 109, 2012
4I3T
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STRUCTURE OF PHOSPHONOACETALDEHYDE DEHYDROGENASE IN THE APO STATE
分子名称:Aldehyde dehydrogenase (NAD+), PHOSPHATE ION
著者Nair, S.K., Agarwal, V.
登録日2012-11-26
公開日2013-11-27
最終更新日2014-02-05
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure and function of phosphonoacetaldehyde dehydrogenase: the missing link in phosphonoacetate formation.
Chem.Biol., 21, 2014
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