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8KE7
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BU of 8ke7 by Molmil
Crystal structure of DNA binding and cleavage core of human topoisomerase 2-beta in a DNA binding-competent conformation
Descriptor: ACETATE ION, DNA topoisomerase 2-beta
Authors:Chan, N.L, Liu, K.T, Chen, S.F.
Deposit date:2023-08-11
Release date:2024-07-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for the Assembly of Type IIA Topoisomerase DNA Cleavage/Religation Center
To Be Published
1RQ3
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BU of 1rq3 by Molmil
Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Deoxyhemoglobin, Deoxyhemoglobin
Descriptor: Hemoglobin alpha chain, Hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE
Authors:Chan, N.L, Kavanaugh, J.S, Rogers, P.H, Arnone, A.
Deposit date:2003-12-04
Release date:2003-12-23
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystallographic analysis of the interaction of nitric oxide with quaternary-T human hemoglobin.
Biochemistry, 43, 2004
1RQ4
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BU of 1rq4 by Molmil
Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Hemoglobin, HEMOGLOBIN EXPOSED TO NO UNDER AEROBIC CONDITIONS
Descriptor: Hemoglobin alpha chain, Hemoglobin beta chain, NITRIC OXIDE, ...
Authors:Chan, N.L, Kavanaugh, J.S, Rogers, P.H, Arnone, A.
Deposit date:2003-12-04
Release date:2003-12-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Crystallographic analysis of the interaction of nitric oxide with quaternary-T human hemoglobin.
Biochemistry, 43, 2004
8W50
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BU of 8w50 by Molmil
Crystal structure of DNA binding and cleavage core of human topoisomerase 2-alpha in a DNA binding-competent conformation
Descriptor: DNA topoisomerase 2-alpha, SULFATE ION
Authors:Chan, N.L, Liu, K.T, Chen, S.F.
Deposit date:2023-08-25
Release date:2024-07-24
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Structural Basis for the Assembly of Type IIA Topoisomerase DNA Cleavage/Religation Center
To Be Published
3L6V
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BU of 3l6v by Molmil
Crystal Structure of the Xanthomonas campestris Gyrase A C-terminal Domain
Descriptor: DNA gyrase subunit A
Authors:Hsieh, T.J, Yen, T.J, Lin, T.S, Chang, H.T, Huang, S.Y, Farh, L, Chan, N.L.
Deposit date:2009-12-26
Release date:2010-03-09
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Twisting of the DNA binding surface by a beta-strand-bearing proline modulates DNA gyrase activity
To be Published
4ZGY
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BU of 4zgy by Molmil
STRUCTURE of HUMAN ORNITHINE DECARBOXYLASE IN COMPLEX WITH A C-TERMINAL FRAGMENT OF ANTIZYME
Descriptor: MAGNESIUM ION, Ornithine decarboxylase, Ornithine decarboxylase antizyme 1, ...
Authors:Wu, H.Y, Chan, N.L.
Deposit date:2015-04-24
Release date:2015-09-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Structural basis of antizyme-mediated regulation of polyamine homeostasis
Proc.Natl.Acad.Sci.USA, 112, 2015
4ZGZ
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BU of 4zgz by Molmil
STRUCTURE OF HUMAN ANTIZYME INHIBITOR IN COMPLEX WITH A C-TERMINAL FRAGMENT OF ANTIZYME
Descriptor: Antizyme inhibitor 1, Ornithine decarboxylase antizyme 1
Authors:Chen, S.F, Wu, H.Y, Chan, N.L.
Deposit date:2015-04-24
Release date:2015-09-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (5.81 Å)
Cite:Structural basis of antizyme-mediated regulation of polyamine homeostasis
Proc.Natl.Acad.Sci.USA, 112, 2015
5GWI
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BU of 5gwi by Molmil
Structure of a Human topoisomerase IIbeta fragment in complex with DNA and E7873R
Descriptor: DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ...
Authors:Wang, Y.R, Chen, S.F, Wu, C.C, Chan, N.L.
Deposit date:2016-09-12
Release date:2017-08-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.737 Å)
Cite:Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017
5GWK
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BU of 5gwk by Molmil
Human topoisomerase IIalpha in complex with DNA and etoposide
Descriptor: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wang, Y.R, Wu, C.C, Chan, N.L.
Deposit date:2016-09-12
Release date:2017-08-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.152 Å)
Cite:Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017
5H02
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BU of 5h02 by Molmil
Crystal structure of Methanohalophilus portucalensis glycine sarcosine N-methyltransferase tetramutant (H21G, E23T, E24N, L28S)
Descriptor: Glycine sarcosine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, TRIMETHYL GLYCINE
Authors:Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L.
Deposit date:2016-10-02
Release date:2016-11-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.776 Å)
Cite:Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity.
Sci Rep, 6, 2016
5GWJ
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BU of 5gwj by Molmil
Structure of a Human topoisomerase IIbeta fragment in complex with DNA and E7873S
Descriptor: DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ...
Authors:Wang, Y.R, Chen, S.F, Wu, C.C, Chan, N.L.
Deposit date:2016-09-12
Release date:2017-08-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.566 Å)
Cite:Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Nucleic Acids Res., 45, 2017
5GWX
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BU of 5gwx by Molmil
Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with S-adenosylmethionine and sarcosine
Descriptor: 1,2-ETHANEDIOL, Glycine sarcosine N-methyltransferase, S-ADENOSYLMETHIONINE, ...
Authors:Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L.
Deposit date:2016-09-14
Release date:2016-11-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.205 Å)
Cite:Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity.
Sci Rep, 6, 2016
5HIK
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BU of 5hik by Molmil
Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with S-adenosylmethionine
Descriptor: 1,2-ETHANEDIOL, Glycine sarcosine N-methyltransferase, S-ADENOSYLMETHIONINE
Authors:Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L.
Deposit date:2016-01-12
Release date:2016-11-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.354 Å)
Cite:Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Sci Rep, 6, 2016
5HIJ
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BU of 5hij by Molmil
Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with betaine
Descriptor: Glycine sarcosine N-methyltransferase, TRIMETHYL GLYCINE
Authors:Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L.
Deposit date:2016-01-12
Release date:2016-11-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Sci Rep, 6, 2016
5HIM
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BU of 5him by Molmil
Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with S-adenosylhomocysteine and dimethylglycine
Descriptor: 1,2-ETHANEDIOL, Glycine sarcosine N-methyltransferase, N,N-DIMETHYLGLYCINE, ...
Authors:Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L.
Deposit date:2016-01-12
Release date:2016-11-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.338 Å)
Cite:Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Sci Rep, 6, 2016
5HIL
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BU of 5hil by Molmil
Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with S-adenosylhomocysteine and sarcosine
Descriptor: 1,2-ETHANEDIOL, Glycine sarcosine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L.
Deposit date:2016-01-12
Release date:2016-11-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.471 Å)
Cite:Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Sci Rep, 6, 2016
5HII
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BU of 5hii by Molmil
Crystal structure of glycine sarcosine N-methyltransferase (GSMT) from Methanohalophilus portucalensis (apo form)
Descriptor: 1,2-ETHANEDIOL, Glycine sarcosine N-methyltransferase
Authors:Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L.
Deposit date:2016-01-12
Release date:2016-11-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Sci Rep, 6, 2016
4UA2
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BU of 4ua2 by Molmil
Crystal structure of dual function transcriptional regulator MerR from Bacillus megaterium MB1
Descriptor: Regulatory protein
Authors:Lin, L.Y, Chang, C.C, Zou, X.W, Huang, C.C, Chan, N.L.
Deposit date:2014-08-07
Release date:2015-07-22
Last modified:2020-01-29
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structural basis of the mercury(II)-mediated conformational switching of the dual-function transcriptional regulator MerR
Nucleic Acids Res., 43, 2015
4UA1
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BU of 4ua1 by Molmil
Crystal structure of dual function transcriptional regulator MerR form Bacillus megaterium MB1 in complex with mercury (II) ion
Descriptor: MERCURY (II) ION, Regulatory protein
Authors:Chang, C.C, Lin, L.Y, Zou, X.W, Huang, C.C, Chan, N.L.
Deposit date:2014-08-07
Release date:2015-07-22
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Structural basis of the mercury(II)-mediated conformational switching of the dual-function transcriptional regulator MerR
Nucleic Acids Res., 43, 2015
4G0W
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BU of 4g0w by Molmil
Human topoisomerase iibeta in complex with DNA and ametantrone
Descriptor: 1,4-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)anthracene-9,10-dione, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C, Li, T.K, Li, Y.C, Chan, N.L.
Deposit date:2012-07-10
Release date:2013-07-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.696 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
4G0U
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BU of 4g0u by Molmil
Human topoisomerase IIbeta in complex with DNA and amsacrine
Descriptor: DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ...
Authors:Wu, C.C, Li, T.K, Li, Y.C, Chan, N.L.
Deposit date:2012-07-10
Release date:2013-07-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
4G0V
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BU of 4g0v by Molmil
Human topoisomerase iibeta in complex with DNA and mitoxantrone
Descriptor: 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C, Li, T.K, Li, Y.C, Chan, N.L.
Deposit date:2012-07-10
Release date:2013-07-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.548 Å)
Cite:On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Nucleic Acids Res., 41, 2013
3QX3
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BU of 3qx3 by Molmil
Human topoisomerase IIbeta in complex with DNA and etoposide
Descriptor: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ...
Authors:Wu, C.C, Li, T.K, Farh, L, Lin, L.Y, Lin, T.S, Yu, Y.J, Yen, T.J, Chiang, C.W, Chan, N.L.
Deposit date:2011-03-01
Release date:2011-07-06
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.162 Å)
Cite:Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide
Science, 333, 2011
6K0E
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BU of 6k0e by Molmil
The quinary complex of AsqJ-Fe-2OG-dehydrocyclopeptin-dioxygen
Descriptor: (3~{Z})-4-methyl-3-(phenylmethylidene)-1~{H}-1,4-benzodiazepine-2,5-dione, 2-OXOGLUTARIC ACID, FE (III) ION, ...
Authors:Liao, H.J, Chan, N.L.
Deposit date:2019-05-06
Release date:2020-03-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.707 Å)
Cite:The quinary complex of AsqJ-Fe-2OG-dehydrocyclopeptin-dioxygen
J.Am.Chem.Soc., 2020
6K0F
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BU of 6k0f by Molmil
The crystal structure of cyclopenin-bound AsqJ quinary complex
Descriptor: (3~{R},3'~{S})-4-methyl-3'-phenyl-spiro[1~{H}-1,4-benzodiazepine-3,2'-oxirane]-2,5-dione, 2-OXOGLUTARIC ACID, FE (III) ION, ...
Authors:Liao, H.J, Chan, N.L.
Deposit date:2019-05-06
Release date:2020-03-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.634 Å)
Cite:The crystal structure of cyclopenin-bound AsqJ quinary complex
J.Am.Chem.Soc., 2020

 

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