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2HG4
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STRUCTURE OF THE KETOSYNTHASE-ACYLTRANSFERASE DIDOMAIN OF MODULE 5 FROM DEBS.
Descriptor:6-Deoxyerythronolide B Synthase, ACETATE ION, SULFATE ION, ...
Authors:Tang, Y., Kim, C.Y., Mathews, I.I., Cane, D.E., Khosla, C.
Deposit date:2006-06-26
Release date:2006-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:The 2.7-A crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.
Proc.Natl.Acad.Sci.Usa, 103, 2006
1KNJ
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CO-CRYSTAL STRUCTURE OF 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE (ISPF) FROM E. COLI INVOLVED IN MEVALONATE-INDEPENDENT ISOPRENOID BIOSYNTHESIS, COMPLEXED WITH CMP/MECDP/MN2+
Descriptor:2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MANGANESE (II) ION, CYTIDINE-5'-MONOPHOSPHATE, ...
Authors:Richard, S.B., Ferrer, J.L., Bowman, M.E., Lillo, A.M., Tetzlaff, C.N., Cane, D.E., Noel, J.P.
Deposit date:2001-12-18
Release date:2002-06-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway.
J.Biol.Chem., 277, 2002
1KNK
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CRYSTAL STRUCTURE OF 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE (ISPF) FROM E. COLI INVOLVED IN MEVALONATE-INDEPENDENT ISOPRENOID BIOSYNTHESIS
Descriptor:2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MANGANESE (II) ION
Authors:Richard, S.B., Ferrer, J.L., Bowman, M.E., Lillo, A.M., Tetzlaff, C.N., Cane, D.E., Noel, J.P.
Deposit date:2001-12-18
Release date:2002-06-18
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway.
J.Biol.Chem., 277, 2002
1DGP
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ARISTOLOCHENE SYNTHASE FARNESOL COMPLEX
Descriptor:ARISTOLOCHENE SYNTHASE, (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol, (2Z,6Z)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol
Authors:Caruthers, J.M., Kang, I., Cane, D.E., Christianson, D.W.
Deposit date:1999-11-24
Release date:2001-02-07
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti.
J.Biol.Chem., 275, 2000
1DI1
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CRYSTAL STRUCTURE OF ARISTOLOCHENE SYNTHASE FROM PENICILLIUM ROQUEFORTI
Descriptor:ARISTOLOCHENE SYNTHASE
Authors:Caruthers, J.M., Kang, I., Cane, D.E., Christianson, D.W., Rynkiewicz, M.J.
Deposit date:1999-11-28
Release date:2000-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti.
J.Biol.Chem., 275, 2000
1HM4
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N219L PENTALENENE SYNTHASE
Descriptor:PENTALENENE SYNTHASE
Authors:Seemann, M., Paschall, C.M., Christianson, D.W., Cane, D.E.
Deposit date:2000-12-04
Release date:2002-08-30
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (3.47 Å)
Cite:Pentalenene synthase. Analysis of active site residues by site-directed mutagenesis.
J.Am.Chem.Soc., 124, 2002
1HM7
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N219L PENTALENENE SYNTHASE
Descriptor:PENTALENENE SYNTHASE
Authors:Seemann, M., Paschall, C.M., Christianson, D.W., Cane, D.E.
Deposit date:2000-12-05
Release date:2002-08-30
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Pentalenene synthase. Analysis of active site residues by site-directed mutagenesis.
J.Am.Chem.Soc., 124, 2002
1I52
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CRYSTAL STRUCTURE OF 4-DIPHOSPHOCYTIDYL-2-C-METHYLERYTHRITOL (CDP-ME) SYNTHASE (YGBP) INVOLVED IN MEVALONATE INDEPENDENT ISOPRENOID BIOSYNTHESIS
Descriptor:4-DIPHOSPHOCYTIDYL-2-C-METHYLERYTHRITOL SYNTHASE, CALCIUM ION, MAGNESIUM ION, ...
Authors:Richard, S.B., Bowman, M.E., Kwiatkowski, W., Kang, I., Chow, C., Lillo, M., Cane, D.E., Noel, J.P.
Deposit date:2001-02-23
Release date:2001-07-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis.
Nat.Struct.Biol., 8, 2001
1INI
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CRYSTAL STRUCTURE OF 4-DIPHOSPHOCYTIDYL-2-C-METHYLERYTHRITOL (CDP-ME) SYNTHETASE (YGBP) INVOLVED IN MEVALONATE INDEPENDENT ISOPRENOID BIOSYNTHESIS, COMPLEXED WITH CDP-ME AND MG2+
Descriptor:4-DIPHOSPHOCYTIDYL-2-C-METHYLERYTHRITOL SYNTHETASE, MAGNESIUM ION, 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL
Authors:Richard, S.B., Bowman, M.E., Kwiatkowski, W., Kang, I., Chow, C., Lillo, A., Cane, D.E., Noel, J.P.
Deposit date:2001-05-14
Release date:2001-11-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis.
Nat.Struct.Biol., 8, 2001
1INJ
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CRYSTAL STRUCTURE OF THE APO FORM OF 4-DIPHOSPHOCYTIDYL-2-C-METHYLERYTHRITOL (CDP-ME) SYNTHETASE (YGBP) INVOLVED IN MEVALONATE INDEPENDENT ISOPRENOID BIOSYNTHESIS
Descriptor:4-DIPHOSPHOCYTIDYL-2-C-METHYLERYTHRITOL SYNTHETASE, CALCIUM ION
Authors:Richard, S.B., Bowman, M.E., Kwiatkowski, W., Kang, I., Chow, C., Lillo, A., Cane, D.E., Noel, J.P.
Deposit date:2001-05-14
Release date:2001-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis.
Nat.Struct.Biol., 8, 2001
1JFA
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TRICHODIENE SYNTHASE FROM FUSARIUM SPOROTRICHIOIDES
Descriptor:TRICHODIENE SYNTHASE, 1,2-ETHANEDIOL
Authors:Rynkiewicz, M.J., Cane, D.E., Christianson, D.W.
Deposit date:2001-06-20
Release date:2001-11-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade.
Proc.Natl.Acad.Sci.USA, 98, 2001
1JFG
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TRICHODIENE SYNTHASE FROM FUSARIUM SPOROTRICHIOIDES COMPLEXED WITH DIPHOSPHATE
Descriptor:TRICHODIENE SYNTHASE, GLYCEROL, MAGNESIUM ION, ...
Authors:Rynkiewicz, M.J., Cane, D.E., Christianson, D.W.
Deposit date:2001-06-20
Release date:2001-11-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade.
Proc.Natl.Acad.Sci.USA, 98, 2001
1KEZ
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CRYSTAL STRUCTURE OF THE MACROCYCLE-FORMING THIOESTERASE DOMAIN OF ERYTHROMYCIN POLYKETIDE SYNTHASE (DEBS TE)
Descriptor:ERYTHRONOLIDE SYNTHASE
Authors:Tsai, S.-C., Miercke, L.J.W., Krucinski, J., Gokhale, R., Chen, J.C.-H., Foster, P.G., Cane, D.E., Khosla, C., Stroud, R.M.
Deposit date:2001-11-19
Release date:2002-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel.
Proc.Natl.Acad.Sci.USA, 98, 2001
1KIY
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D100E TRICHODIENE SYNTHASE
Descriptor:trichodiene synthase, 1,2-ETHANEDIOL
Authors:Rynkiewicz, M.J., Cane, D.E., Christianson, D.W.
Deposit date:2001-12-03
Release date:2002-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray crystal structures of D100E trichodiene synthase and its pyrophosphate complex reveal the basis for terpene product diversity.
Biochemistry, 41, 2002
1KIZ
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D100E TRICHODIENE SYNTHASE COMPLEXED WITH PYROPHOSPHATE
Descriptor:trichodiene synthase, 1,2-ETHANEDIOL, MAGNESIUM ION, ...
Authors:Rynkiewicz, M.J., Cane, D.E., Christianson, D.W.
Deposit date:2001-12-03
Release date:2002-03-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:X-ray crystal structures of D100E trichodiene synthase and its pyrophosphate complex reveal the basis for terpene product diversity.
Biochemistry, 41, 2002
1M5W
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1.96 A CRYSTAL STRUCTURE OF PYRIDOXINE 5'-PHOSPHATE SYNTHASE IN COMPLEX WITH 1-DEOXY-D-XYLULOSE PHOSPHATE
Descriptor:Pyridoxal phosphate biosynthetic protein pdxJ, 1-DEOXY-D-XYLULOSE-5-PHOSPHATE, PHOSPHATE ION
Authors:Yeh, J.I., Du, S., Pohl, E., Cane, D.E.
Deposit date:2002-07-10
Release date:2003-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Multistate Binding in Pyridoxine 5'-Phosphate Synthase: 1.96 A Crystal Structure in Complex with 1-deoxy-D-xylulose phosphate
Biochemistry, 41, 2002
1MN6
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THIOESTERASE DOMAIN FROM PICROMYCIN POLYKETIDE SYNTHASE, PH 7.6
Descriptor:polyketide synthase IV
Authors:Tsai, S.-C., Lu, H., Cane, D.E., Khosla, C., Stroud, R.M.
Deposit date:2002-09-05
Release date:2003-02-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
Biochemistry, 41, 2002
1MNA
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THIOESTERASE DOMAIN OF PICROMYCIN POLYKETIDE SYNTHASE (PICS TE), PH 8.0
Descriptor:polyketide synthase IV
Authors:Tsai, S.-C., Lu, H., Cane, D.E., Khosla, C., Stroud, R.M.
Deposit date:2002-09-05
Release date:2003-02-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
Biochemistry, 41, 2002
1MNQ
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THIOESTERASE DOMAIN OF PICROMYCIN POLYKETIDE SYNTHASE (PICS TE), PH 8.4
Descriptor:polyketide synthase IV
Authors:Tsai, S.-C., Lu, H., Cane, D.E., Khosla, C., Stroud, R.M.
Deposit date:2002-09-05
Release date:2003-02-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
Biochemistry, 41, 2002
1MO2
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THIOESTERASE DOMAIN FROM 6-DEOXYERYTHRONOLIDE SYNTHASE (DEBS TE), PH 8.5
Descriptor:Erythronolide synthase, modules 5 and 6
Authors:Tsai, S.-C., Lu, H., Cane, D.E., Khosla, C., Stroud, R.M.
Deposit date:2002-09-05
Release date:2003-02-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
Biochemistry, 41, 2002
1PS6
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CRYSTAL STRUCTURE OF E.COLI PDXA
Descriptor:4-hydroxythreonine-4-phosphate dehydrogenase, ZINC ION, 4-HYDROXY-L-THREONINE-5-MONOPHOSPHATE
Authors:Sivaraman, J., Li, Y., Banks, J., Cane, D.E., Matte, A., Cygler, M.
Deposit date:2003-06-20
Release date:2003-11-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure of Escherichia coli PdxA, an Enzyme Involved in the Pyridoxal Phosphate Biosynthesis Pathway
J.Biol.Chem., 278, 2003
1PS7
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CRYSTAL STRUCTURE OF E.COLI PDXA
Descriptor:4-hydroxythreonine-4-phosphate dehydrogenase, ZINC ION
Authors:Sivaraman, J., Li, Y., Banks, J., Cane, D.E., Matte, A., Cygler, M.
Deposit date:2003-06-20
Release date:2003-11-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Crystal Structure of Escherichia coli PdxA, an Enzyme Involved in the Pyridoxal Phosphate Biosynthesis Pathway
J.Biol.Chem., 278, 2003
1PTM
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CRYSTAL STRUCTURE OF E.COLI PDXA
Descriptor:4-hydroxythreonine-4-phosphate dehydrogenase, ZINC ION, PHOSPHATE ION
Authors:Sivaraman, J., Li, Y., Banks, J., Cane, D.E., Matte, A., Cygler, M., Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI)
Deposit date:2003-06-23
Release date:2003-11-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal Structure of Escherichia coli PdxA, an Enzyme Involved in the Pyridoxal Phosphate Biosynthesis Pathway
J.Biol.Chem., 278, 2003
1YJ4
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Y305F TRICHODIENE SYNTHASE
Descriptor:Trichodiene synthase, 1,2-ETHANEDIOL
Authors:Vedula, L.S., Rynkiewicz, M.J., Pyun, H.J., Coates, R.M., Cane, D.E., Christianson, D.W.
Deposit date:2005-01-13
Release date:2005-03-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular Recognition of the Substrate Diphosphate Group Governs Product Diversity in Trichodiene Synthase Mutants.
Biochemistry, 44, 2005
1YYQ
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Y305F TRICHODIENE SYNTHASE COMPLEXED WITH PYROPHOSPHATE
Descriptor:Trichodiene synthase, MAGNESIUM ION, PYROPHOSPHATE 2-
Authors:Vedula, L.S., Rynkiewicz, M.J., Pyun, H.J., Coates, R.M., Cane, D.E., Christianson, D.W.
Deposit date:2005-02-25
Release date:2005-03-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular Recognition of the Substrate Diphosphate Group Governs Product Diversity in Trichodiene Synthase Mutants.
Biochemistry, 44, 2005