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1RZU
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CRYSTAL STRUCTURE OF THE GLYCOGEN SYNTHASE FROM A. TUMEFACIENS IN COMPLEX WITH ADP
Descriptor:Glycogen synthase 1, ADENOSINE-5'-DIPHOSPHATE
Authors:Buschiazzo, A., Guerin, M.E., Ugalde, J.E., Ugalde, R.A., Shepard, W., Alzari, P.M.
Deposit date:2003-12-29
Release date:2004-08-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of glycogen synthase: homologous enzymes catalyze glycogen synthesis and degradation.
Embo J., 23, 2004
1RZV
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CRYSTAL STRUCTURE OF THE GLYCOGEN SYNTHASE FROM AGROBACTERIUM TUMEFACIENS (NON-COMPLEXED FORM)
Descriptor:Glycogen synthase 1
Authors:Buschiazzo, A., Guerin, M.E., Ugalde, J.E., Ugalde, R.A., Shepard, W., Alzari, P.M.
Deposit date:2003-12-29
Release date:2004-08-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of glycogen synthase: homologous enzymes catalyze glycogen synthesis and degradation.
Embo J., 23, 2004
1W61
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PROLINE RACEMASE IN COMPLEX WITH 2 MOLECULES OF PYRROLE-2-CARBOXYLIC ACID (HOLO FORM)
Descriptor:B-CELL MITOGEN, PYRROLE-2-CARBOXYLATE
Authors:Buschiazzo, A., Alzari, P.
Deposit date:2004-08-11
Release date:2006-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure,Catalytic Mechanism and Mitogenic Properties of Trypanosoma Cruzi Proline Racemase
Proc.Natl.Acad.Sci.USA, 103, 2006
1W62
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PROLINE RACEMASE IN COMPLEX WITH ONE MOLECULE OF PYRROLE-2-CARBOXYLIC ACID (HEMI FORM)
Descriptor:Proline racemase A, PYRROLE-2-CARBOXYLATE
Authors:Buschiazzo, A., Alzari, P.
Deposit date:2004-08-12
Release date:2006-02-03
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase.
Proc. Natl. Acad. Sci. U.S.A., 103, 2006
1MR5
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ORTHORHOMBIC FORM OF TRYPANOSOMA CRUZI TRANS-SIALIDASE
Descriptor:trans-sialidase
Authors:Buschiazzo, A., Amaya, M.F., Cremona, M.L., Frasch, A.C., Alzari, P.M.
Deposit date:2002-09-18
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis
Mol.Cell, 10, 2002
1MS0
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MONOCLINIC FORM OF TRYPANOSOMA CRUZI TRANS-SIALIDASE, IN COMPLEX WITH 3-DEOXY-2,3-DEHYDRO-N-ACETYLNEURAMINIC ACID (DANA)AND LACTOSE
Descriptor:trans-sialidase, BETA-LACTOSE, 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID
Authors:Buschiazzo, A., Amaya, M.F., Cremona, M.L., Frasch, A.C., Alzari, P.M.
Deposit date:2002-09-19
Release date:2003-03-25
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis
Mol.Cell, 10, 2002
1MS1
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MONOCLINIC FORM OF TRYPANOSOMA CRUZI TRANS-SIALIDASE, IN COMPLEX WITH 3-DEOXY-2,3-DEHYDRO-N-ACETYLNEURAMINIC ACID (DANA)
Descriptor:trans-sialidase, 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, GLYCEROL
Authors:Buschiazzo, A., Amaya, M.F., Cremona, M.L., Frasch, A.C., Alzari, P.M.
Deposit date:2002-09-19
Release date:2003-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis
Mol.Cell, 10, 2002
1MS3
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MONOCLINIC FORM OF TRYPANOSOMA CRUZI TRANS-SIALIDASE
Descriptor:trans-sialidase
Authors:Buschiazzo, A., Amaya, M.F., Cremona, M.L., Frasch, A.C., Alzari, P.M.
Deposit date:2002-09-19
Release date:2003-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis
Mol.Cell, 10, 2002
1MS4
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TRICLINIC FORM OF TRYPANOSOMA CRUZI TRANS-SIALIDASE
Descriptor:trans-sialidase
Authors:Buschiazzo, A., Amaya, M.F., Cremona, M.L., Frasch, A.C., Alzari, P.M.
Deposit date:2002-09-19
Release date:2003-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis
Mol.Cell, 10, 2002
1MS5
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TRICLINIC FORM OF TRYPANOSOMA CRUZI TRANS-SIALIDASE, SOAKED WITH N-ACETYLNEURAMINYL-A-2,3-THIO-GALACTOSIDE (NA-S-GAL)
Descriptor:trans-sialidase
Authors:Buschiazzo, A., Amaya, M.F., Cremona, M.L., Frasch, A.C., Alzari, P.M.
Deposit date:2002-09-19
Release date:2003-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis
Mol.Cell, 10, 2002
1MS8
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TRICLINIC FORM OF TRYPANOSOMA CRUZI TRANS-SIALIDASE, IN COMPLEX WITH 3-DEOXY-2,3-DEHYDRO-N-ACETYLNEURAMINIC ACID (DANA)
Descriptor:trans-sialidase, 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID
Authors:Buschiazzo, A., Amaya, M.F., Cremona, M.L., Frasch, A.C., Alzari, P.M.
Deposit date:2002-09-19
Release date:2003-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis
Mol.Cell, 10, 2002
1MS9
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TRICLINIC FORM OF TRYPANOSOMA CRUZI TRANS-SIALIDASE, IN COMPLEX WITH LACTOSE
Descriptor:trans-sialidase, BETA-LACTOSE
Authors:Buschiazzo, A., Amaya, M.F., Cremona, M.L., Frasch, A.C., Alzari, P.M.
Deposit date:2002-09-19
Release date:2003-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:The crystal structure and mode of action of trans-sialidase, a key enzyme of Trypanosoma cruzi pathogenesis
Mol.Cell, 10, 2002
1MZ5
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TRYPANOSOMA RANGELI SIALIDASE
Descriptor:sialidase, N-ACETYL-D-GLUCOSAMINE
Authors:Buschiazzo, A., Tavares, G.A., Campetella, O., Spinelli, S., Cremona, M.L., Paris, G., Amaya, M.F., Frasch, A.C.C., Alzari, P.M.
Deposit date:2002-10-05
Release date:2002-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of sialyltransferase activity in trypanosomal sialidases
Embo J., 19, 2000
1MZ6
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TRYPANOSOMA RANGELI SIALIDASE IN COMPLEX WITH THE INHIBITOR DANA
Descriptor:sialidase, N-ACETYL-D-GLUCOSAMINE, 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID
Authors:Buschiazzo, A., Tavares, G.A., Campetella, O., Spinelli, S., Cremona, M.L., Paris, G., Amaya, M.F., Frasch, A.C.C., Alzari, P.M.
Deposit date:2002-10-05
Release date:2002-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of sialyltransferase activity in trypanosomal sialidases
Embo J., 19, 2000
3M8O
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HUMAN IGA1 FAB FRAGMENT
Descriptor:IMMUNOGLOBULIN A1 LIGHT CHAIN, IMMUNOGLOBULIN A1 HEAVY CHAIN, CHLORIDE ION, ...
Authors:Buschiazzo, A., Trajtenberg, F., Correa, A., Oppezzo, P., Pritsch, O., Dighiero, G.
Deposit date:2010-03-18
Release date:2011-03-30
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of a human IgA1 Fab fragment at 1.55 angstrom resolution: potential effect of the constant domains on antigen-affinity modulation
Acta Crystallogr.,Sect.D, 69, 2013
2F3X
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CRYSTAL STRUCTURE OF FAPR (IN COMPLEX WITH EFFECTOR)- A GLOBAL REGULATOR OF FATTY ACID BIOSYNTHESIS IN B. SUBTILIS
Descriptor:Transcription factor fapR, MALONYL-COENZYME A
Authors:Buschiazzo, A., Guerin, M.E., Alzari, P.M.
Deposit date:2005-11-22
Release date:2006-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis of lipid biosynthesis regulation in Gram-positive bacteria.
Embo J., 25, 2006
2F41
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CRYSTAL STRUCTURE OF FAPR- A GLOBAL REGULATOR OF FATTY ACID BIOSYNTHESIS IN B. SUBTILIS
Descriptor:Transcription factor fapR
Authors:Buschiazzo, A., Guerin, M.E., Alzari, P.M.
Deposit date:2005-11-22
Release date:2006-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of lipid biosynthesis regulation in Gram-positive bacteria.
Embo J., 25, 2006
3B69
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T CRUZI TRANS-SIALIDASE COMPLEX WITH BENZOYLATED NANA DERIVATIVE
Descriptor:Trans-sialidase, CHLORIDE ION, 5-(acetylamino)-9-(benzoylamino)-3,5,9-trideoxy-3-fluoro-D-erythro-alpha-L-manno-non-2-ulopyranosonic acid, ...
Authors:Buschiazzo, A.
Deposit date:2007-10-28
Release date:2008-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:A new generation of specific Trypanosoma cruzi trans-sialidase inhibitors.
Angew.Chem.Int.Ed.Engl., 47, 2008
3OPZ
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CRYSTAL STRUCTURE OF TRANS-SIALIDASE IN COMPLEX WITH THE FAB FRAGMENT OF A NEUTRALIZING MONOCLONAL IGG ANTIBODY
Descriptor:Trans-sialidase, heavy chain of the Fab fragment of immunoglobulin G, light chain of the Fab fragment of immunoglobulin G, ...
Authors:Larrieux, N., Muia, R., Campetella, O., Buschiazzo, A.
Deposit date:2010-09-02
Release date:2011-11-09
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Trypanosoma cruzi trans-sialidase in complex with a neutralizing antibody: structure/function studies towards the rational design of inhibitors.
Plos Pathog., 8, 2012
5K0W
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CRYSTAL STRUCTURE OF THE METALLO-BETA-LACTAMASE GOB-18 FROM ELIZABETHKINGIA MENINGOSEPTICA
Descriptor:Class B carbapenemase GOB-18, ZINC ION, CHLORIDE ION, ...
Authors:Buschiazzo, A., Larrieux, N., Vila, A.J., Lisa, M.N., Moran-Barrio, J.
Deposit date:2016-05-17
Release date:2016-08-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Crystal Structure of the Metallo-beta-Lactamase GOB in the Periplasmic Dizinc Form Reveals an Unusual Metal Site.
Antimicrob.Agents Chemother., 60, 2016
6PWB
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RIGID BODY FITTING OF FLAGELLIN FLAB, AND FLAGELLAR COILING PROTEINS, FCPA AND FCPB, INTO A 10 ANGSTROM STRUCTURE OF THE ASYMMETRIC FLAGELLAR FILAMENT PURIFIED FROM LEPTOSPIRA BIFLEXA PATOC WT CELLS RESOLVED VIA SUBTOMOGRAM AVERAGING
Descriptor:Flagellin B1 (FlaB1), Flagellar coiling protein A (FcpA), Flagellar coiling protein B (FcpB)
Authors:Gibson, K.H., Sindelar, C.V., Trajtenberg, F., Buschiazzo, A., San Martin, F., Mechaly, A.
Deposit date:2019-07-22
Release date:2020-03-25
Method:ELECTRON MICROSCOPY (9.83 Å)
Cite:An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete.
Elife, 9, 2020
1S0I
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TRYPANOSOMA CRUZI TRANS-SIALIDASE IN COMPLEX WITH SIALYL-LACTOSE (MICHAELIS COMPLEX)
Descriptor:trans-sialidase, 5-(ACETYLAMINO)-3,5-DIDEOXYNON-2-ULOPYRANONOSYL-(2->3)-BETA-D-LYXO-HEXOPYRANOSYL-(1->4)HEXOPYRANOSE
Authors:Amaya, M.F., Watts, A.G., Damager, I., Wehenkel, A., Nguyen, T., Buschiazzo, A., Paris, G., Frasch, A.C., Withers, S.G., Alzari, P.M.
Deposit date:2003-12-31
Release date:2004-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Insights into the Catalytic Mechanism of Trypanosoma cruzi trans-Sialidase.
Structure, 12, 2004
1S0J
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TRYPANOSOMA CRUZI TRANS-SIALIDASE IN COMPLEX WITH MUNANA (MICHAELIS COMPLEX)
Descriptor:trans-sialidase, 4-METHYL-2-OXO-2H-CHROMEN-7-YL 5-(ACETYLAMINO)-3,5-DIDEOXY-L-ERYTHRO-NON-2-ULOPYRANOSIDONIC ACID
Authors:Amaya, M.F., Watts, A.G., Damager, I., Wehenkel, A., Nguyen, T., Buschiazzo, A., Paris, G., Frasch, A.C., Withers, S.G., Alzari, P.M.
Deposit date:2003-12-31
Release date:2004-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Insights into the Catalytic Mechanism of Trypanosoma cruzi trans-Sialidase.
Structure, 12, 2004
6NQW
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FLAGELLAR PROTEIN FCPA FROM LEPTOSPIRA BIFLEXA - HEXAGONAL FORM
Descriptor:Flagellar coiling protein A, GLYCEROL, PHOSPHATE ION, ...
Authors:San Martin, F., Trajtenberg, F., Larrieux, N., Buschiazzo, A.
Deposit date:2019-01-22
Release date:2020-01-29
Last modified:2020-03-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:An asymmetric sheath controls flagellar supercoiling and motility in the Leptospira spirochete
Elife, 9, 2020
6NQX
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FLAGELLAR PROTEIN FCPA FROM LEPTOSPIRA BIFLEXA / PRIMITIVE MONOCLINIC FORM
Descriptor:Flagellar coiling protein A, GLYCEROL
Authors:Mechaly, A., Larrieux, N., Trajtenberg, F., Buschiazzo, A.
Deposit date:2019-01-22
Release date:2020-01-29
Last modified:2020-03-18
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:An asymmetric sheath controls flagellar supercoiling and motility in the Leptospira spirochete
Elife, 9, 2020