3OPZ

Crystal structure of trans-sialidase in complex with the Fab fragment of a neutralizing monoclonal IgG antibody

Summary for 3OPZ

Entry DOI	10.2210/pdb3opz/pdb
Descriptor	Trans-sialidase, heavy chain of the Fab fragment of immunoglobulin G, light chain of the Fab fragment of immunoglobulin G, ... (6 entities in total)
Functional Keywords	six-bladed beta-propeller neuraminidase immunoglobulin domain, viral protein-immune system complex, hydrolase-immune system complex, hydrolase/immune system
Biological source	Trypanosoma cruzi More
Total number of polymer chains	9
Total formula weight	356124.46
Authors	Larrieux, N.,Muia, R.,Campetella, O.,Buschiazzo, A. (deposition date: 2010-09-02, release date: 2011-11-09, Last modification date: 2021-10-06)
Primary citation	Buschiazzo, A.,Muia, R.,Larrieux, N.,Pitcovsky, T.,Mucci, J.,Campetella, O. Trypanosoma cruzi trans-sialidase in complex with a neutralizing antibody: structure/function studies towards the rational design of inhibitors. Plos Pathog., 8:e1002474-e1002474, 2012 Cited by PubMed: 22241998 DOI: 10.1371/journal.ppat.1002474 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation