3OPZ
Crystal structure of trans-sialidase in complex with the Fab fragment of a neutralizing monoclonal IgG antibody
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004308 | molecular_function | exo-alpha-sialidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006689 | biological_process | ganglioside catabolic process |
| A | 0009313 | biological_process | oligosaccharide catabolic process |
| A | 0016020 | cellular_component | membrane |
| B | 0004308 | molecular_function | exo-alpha-sialidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006689 | biological_process | ganglioside catabolic process |
| B | 0009313 | biological_process | oligosaccharide catabolic process |
| B | 0016020 | cellular_component | membrane |
| C | 0004308 | molecular_function | exo-alpha-sialidase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006689 | biological_process | ganglioside catabolic process |
| C | 0009313 | biological_process | oligosaccharide catabolic process |
| C | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NA A 635 |
| Chain | Residue |
| A | LYS22 |
| A | ARG87 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DIO A 636 |
| Chain | Residue |
| A | ASP59 |
| A | TYR119 |
| A | ARG245 |
| A | TRP312 |
| A | ARG314 |
| A | TYR342 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DIO B 635 |
| Chain | Residue |
| B | TYR119 |
| B | GLU230 |
| B | ARG245 |
| B | TYR342 |
| B | ASP59 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR191-HIS197 |
