Author results

2JII
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STRUCTURE OF VACCINIA RELATED KINASE 3
Descriptor:SERINE/THREONINE-PROTEIN KINASE VRK3 MOLECULE: VACCINIA RELATED KINASE 3, 1,2-ETHANEDIOL
Authors:Bunkoczi, G., Eswaran, J., Pike, A.C.W., Uppenberg, J., Ugochukwu, E., von Delft, F., Cooper, C., Salah, E., Savitsky, P., Burgess-Brown, N., Keates, T., Fedorov, O., Sobott, F., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Weigelt, J., Knapp, S.
Deposit date:2007-06-28
Release date:2007-07-10
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site.
Structure, 17, 2009
2OV2
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THE CRYSTAL STRUCTURE OF THE HUMAN RAC3 IN COMPLEX WITH THE CRIB DOMAIN OF HUMAN P21-ACTIVATED KINASE 4 (PAK4)
Descriptor:Ras-related C3 botulinum toxin substrate 3, Serine/threonine-protein kinase PAK 4, MAGNESIUM ION, ...
Authors:Ugochukwu, E., Yang, X., Elkins, J.M., Burgess-Brown, N., Bunkoczi, G., Debreczeni, J.E.D., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2007-02-12
Release date:2007-03-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 4 (PAK4)
To be Published
2P6X
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CRYSTAL STRUCTURE OF HUMAN TYROSINE PHOSPHATASE PTPN22
Descriptor:Tyrosine-protein phosphatase non-receptor type 22, 1,2-ETHANEDIOL, CHLORIDE ION
Authors:Ugochukwu, E., Salah, E., Barr, A., Shrestha, L., Alfano, I., Burgess-Brown, N., King, O., Umeano, C., Papagrigoriou, E., Pike, A.C.W., Bunkoczi, G., Turnbull, A., Uppenberg, J., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-03-19
Release date:2007-04-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2PA1
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STRUCTURE OF THE PDZ DOMAIN OF HUMAN PDLIM2 BOUND TO A C-TERMINAL EXTENSION FROM HUMAN BETA-TROPOMYOSIN
Descriptor:PDZ and LIM domain protein 2, CHLORIDE ION
Authors:Uppenberg, J., Shrestha, L., Elkins, J., Burgess-Brown, N., Salah, E., Bunkoczi, G., Papagrigoriou, E., Pike, A.C.W., Turnbull, A.P., Ugochukwu, E., Umeano, C., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2007-03-27
Release date:2007-05-01
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the PDZ domain of human PDLIM2 bound to a C-terminal extension from human beta-tropomyosin.
To be Published
2PKT
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CRYSTAL STRUCTURE OF THE HUMAN CLP-36 (PDLIM1) BOUND TO THE C-TERMINAL PEPTIDE OF HUMAN ALPHA-ACTININ-1
Descriptor:PDZ and LIM domain protein 1, CALCIUM ION, CHLORIDE ION, ...
Authors:Uppenberg, J., Gileadi, C., Elkins, J., Bray, J., Burgess-Brown, N., Salah, E., Gileadi, O., Bunkoczi, G., Ugochukwu, E., Umeano, C., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2007-04-18
Release date:2007-05-08
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The crystal structure of the human CLP-36 (PDLIM1) bound to the C-terminal peptide of human alpha-actinin-1.
To be Published
2PPI
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STRUCTURE OF THE BTB (TRAMTRACK AND BRIC A BRAC) DOMAIN OF HUMAN GIGAXONIN
Descriptor:Gigaxonin
Authors:Amos, A., Turnbull, A.P., Tickle, J., Keates, T., Bullock, A., Savitsky, P., Burgess-Brown, N., Debreczeni, J.E., Ugochukwu, E., Umeano, C., Pike, A.C.W., Papagrigoriou, E., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-04-30
Release date:2007-05-08
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the BTB (Tramtrack and Bric a brac) domain of human Gigaxonin.
To be Published
2PQ5
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CRYSTAL STRUCTURE OF DUAL SPECIFICITY PROTEIN PHOSPHATASE 13 (DUSP13)
Descriptor:Dual specificity protein phosphatase 13
Authors:Ugochukwu, E., Salah, E., Savitsky, P., Barr, A., Pantic, N., Niesen, F., Burgess-Brown, N., Berridge, G., Bunkoczi, G., Uppenberg, J., Pike, A.C.W., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-05-01
Release date:2007-05-22
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of Dual specificity protein phosphatase 13 (DUSP13).
To be Published
2Q3G
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STRUCTURE OF THE PDZ DOMAIN OF HUMAN PDLIM7 BOUND TO A C-TERMINAL EXTENSION FROM HUMAN BETA-TROPOMYOSIN
Descriptor:PDZ and LIM domain protein 7, 1,2-ETHANEDIOL, CHLORIDE ION
Authors:Gileadi, C., Papagrigoriou, E., Elkins, J., Burgess-Brown, N., Salah, E., Gileadi, O., Umeano, C., Bunkoczi, G., von Delft, F., Uppenberg, J., Pike, A.C.W., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2007-05-30
Release date:2007-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:Structure of the PDZ domain of human PDLIM7 bound to a C-terminal extension from human beta-tropomyosin
To be Published
2QEP
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CRYSTAL STRUCTURE OF THE D1 DOMAIN OF PTPRN2 (IA2BETA)
Descriptor:Receptor-type tyrosine-protein phosphatase N2, CHLORIDE ION
Authors:Ugochukwu, E., Barr, A., Alfano, I., Berridge, G., Burgess-Brown, N., Das, S., Fedorov, O., King, O., Niesen, F., Watt, S., Savitsky, P., Salah, E., Pike, A.C.W., Bunkoczi, G., von Delft, F., Sundstrom, M., Edwards, A., Arrowsmith, C.H., Weigelt, J., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-06-26
Release date:2007-07-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2QME
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CRYSTAL STRUCTURE OF HUMAN RAC3 IN COMPLEX WITH CRIB DOMAIN OF HUMAN P21-ACTIVATED KINASE 1 (PAK1)
Descriptor:Ras-related C3 botulinum toxin substrate 3, CRIB domain of the Serine/threonine-protein kinase PAK 1, MAGNESIUM ION, ...
Authors:Ugochukwu, E., Yang, X., Elkins, J.M., Burgess-Brown, N., Bunkoczi, G., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Doyle, D., Structural Genomics Consortium (SGC)
Deposit date:2007-07-16
Release date:2007-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 1 (PAK1).
To be Published
2UZC
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STRUCTURE OF HUMAN PDLIM5 IN COMPLEX WITH THE C-TERMINAL PEPTIDE OF HUMAN ALPHA-ACTININ-1
Descriptor:PDZ AND LIM DOMAIN 5, CHLORIDE ION, 1,2-ETHANEDIOL
Authors:Bunkoczi, G., Elkins, J., Salah, E., Burgess-Brown, N., Papagrigoriou, E., Pike, A.C.W., Turnbull, A., Gileadi, O., von Delft, F., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Weigelt, J., Doyle, D.
Deposit date:2007-04-27
Release date:2007-05-08
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms.
Protein Sci., 19, 2010
2V1W
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CRYSTAL STRUCTURE OF HUMAN LIM PROTEIN RIL (PDLIM4) PDZ DOMAIN BOUND TO THE C-TERMINAL PEPTIDE OF HUMAN ALPHA-ACTININ-1
Descriptor:PDZ AND LIM DOMAIN PROTEIN 4, 1,2-ETHANEDIOL, MAGNESIUM ION, ...
Authors:Soundararajan, M., Shrestha, L., Pike, A.C.W., Salah, E., Burgess-Brown, N., Elkins, J., Umeano, C., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Doyle, D.
Deposit date:2007-05-30
Release date:2007-06-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Unusual Binding Interactions in Pdz Domain Crystal Structures Help Explain Binding Mechanisms.
Protein Sci., 19, 2010
2V1X
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CRYSTAL STRUCTURE OF HUMAN RECQ-LIKE DNA HELICASE
Descriptor:ATP-DEPENDENT DNA HELICASE Q1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Pike, A.C.W., Shrestha, B., Burgess-Brown, N., King, O., Ugochukwu, E., Watt, S., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Gileadi, O.
Deposit date:2007-05-30
Release date:2007-07-03
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the Human Recq1 Helicase Reveals a Putative Strand-Separation Pin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2V7O
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CRYSTAL STRUCTURE OF HUMAN CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE II GAMMA
Descriptor:CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II GAMMA CHAIN, BISINDOLYLMALEIMIDE IX, 1,2-ETHANEDIOL
Authors:Pike, A.C.W., Rellos, P., Fedorov, O., Burgess-Brown, N., Shrestha, L., Ugochukwu, E., Pilka, E.S., von Delft, F., Edwards, A., Weigelt, J., Arrowsmith, C.H., Sundstrom, M., Knapp, S.
Deposit date:2007-07-31
Release date:2007-09-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of the Camkiidelta/Calmodulin Complex Reveals the Molecular Mechanism of Camkii Kinase Activation.
Plos Biol., 8, 2010
2VPH
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CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE, NON- RECEPTOR TYPE 4, PDZ DOMAIN
Descriptor:TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 4
Authors:Roos, A.K., Wang, J., Burgess-Brown, N., Elkins, J.M., Kavanagh, K., Pike, A.C.W., Filippakopoulos, P., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Bountra, C., Knapp, S.
Deposit date:2008-02-29
Release date:2008-03-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of the Human Protein Tyrosine Phosphatase, Non-Receptor Type 4, Pdz Domain
To be Published
2VSV
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CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN RHOPHILIN-2
Descriptor:RHOPHILIN-2
Authors:Pike, A.C.W., Kochan, G., Sun, Z., Shafqat, N., Pilka, E.S., Roos, A., Elkins, J., Burgess-Brown, N., Murray, J.W., von Delft, F., Wikstrom, M., Edwards, A., Arrowsmith, C.H., Bountra, C., Oppermann, U.
Deposit date:2008-04-29
Release date:2008-07-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal Structure of the Pdz Domain of Human Rhophilin-2
To be Published
2VSW
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THE STRUCTURE OF THE RHODANESE DOMAIN OF THE HUMAN DUAL SPECIFICITY PHOSPHATASE 16
Descriptor:DUAL SPECIFICITY PROTEIN PHOSPHATASE 16
Authors:Murray, J.W., Barr, A., Pike, A.C.W., Elkins, J., Phillips, C., Wang, J., Savitsky, P., Roos, A., Bishop, S., Wickstroem, M., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Burgess-Brown, N., Pantic, N., Bray, J., von Delft, F., Gileadi, O., Knapp, S.
Deposit date:2008-04-30
Release date:2008-07-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Structure of the Rhodanese Domain of the Human Dual Specifity Phosphatase 16
To be Published
2VUW
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STRUCTURE OF HUMAN HASPIN KINASE DOMAIN
Descriptor:SERINE/THREONINE-PROTEIN KINASE HASPIN, IODIDE ION, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, ...
Authors:Eswaran, J., Murray, J.W., Filippakopoulos, P., Soundararajan, M., Pike, A.C.W., von Delft, F., Picaud, S., Keates, T., King, O., Wickstroem, M., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Fedorov, O., Burgess-Brown, N., Bray, J., Knapp, S.
Deposit date:2008-05-30
Release date:2008-09-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and Functional Characterization of the Atypical Human Kinase Haspin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2VWR
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CRYSTAL STRUCTURE OF THE SECOND PDZ DOMAIN OF NUMB-BINDING PROTEIN 2
Descriptor:LIGAND OF NUMB PROTEIN X 2
Authors:Roos, A.K., Guo, K., Burgess-Brown, N., Yue, W.W., Elkins, J.M., Pike, A.C.W., Filippakopoulos, P., Arrowsmith, C.H., Wikstom, M., Edwards, A., von Delft, F., Bountra, C., Doyle, D., Oppermann, U.
Deposit date:2008-06-26
Release date:2008-09-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal Structure of the Second Pdz Domain of the Human Numb-Binding Protein 2
To be Published
2VX3
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CRYSTAL STRUCTURE OF THE HUMAN DUAL SPECIFICITY TYROSINE- PHOSPHORYLATION-REGULATED KINASE 1A
Descriptor:DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION- REGULATED KINASE 1A, N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide, CHLORIDE ION, ...
Authors:Roos, A.K., Soundararajan, M., Pike, A.C.W., Federov, O., King, O., Burgess-Brown, N., Philips, C., Filippakopoulos, P., Arrowsmith, C.H., Wikstrom, M., Edwards, A., von Delft, F., Bountra, C., Knapp, S.
Deposit date:2008-06-30
Release date:2008-09-16
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of Down Syndrome Kinases, Dyrks, Reveal Mechanisms of Kinase Activation and Substrate Recognition.
Structure, 21, 2013
2VZ6
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STRUCTURE OF HUMAN CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE TYPE II ALPHA (CAMK2A) IN COMPLEX WITH INDIRUBIN E804
Descriptor:CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN, (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}, S-1,2-PROPANEDIOL
Authors:Pike, A.C.W., Rellos, P., King, O., Salah, E., Parizotto, E., Fedorov, O., Shrestha, L., Burgess-Brown, N., Roos, A., Murray, J.W., von Delft, F., Edwards, A., Arrowsmith, C.H., Wikstroem, M., Bountra, C., Knapp, S.
Deposit date:2008-07-30
Release date:2008-08-26
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the Camkiidelta/Calmodulin Complex Reveals the Molecular Mechanism of Camkii Kinase Activation.
Plos Biol., 8, 2010
2W2C
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STRUCTURE OF THE TETRADECAMERIC OLIGOMERISATION DOMAIN OF CALCIUM- CALMODULIN DEPENDENT PROTEIN KINASE II DELTA
Descriptor:CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN, ACETATE ION, CADMIUM ION
Authors:Pike, A.C.W., Rellos, P., Sethi, R., Salah, E., Burgess-Brown, N., Shrestha, L., Roos, A., Murray, J.W., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Knapp, S.
Deposit date:2008-10-28
Release date:2008-12-23
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the Camkiidelta/Calmodulin Complex Reveals the Molecular Mechanism of Camkii Kinase Activation.
Plos Biol., 8, 2010
2W4O
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CRYSTAL STRUCTURE OF HUMAN CAMK4 IN COMPLEX WITH 4-AMINO(SULFAMOYL- PHENYLAMINO)-TRIAZOLE-CARBOTHIOIC ACID (2,6-DIFLUORO-PHENYL)-AMIDE)
Descriptor:CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE IV, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Authors:Muniz, J.R.C., Rellos, P., Gileadi, O., Fedorov, O., Filippakopoulos, P., Salah, E., Pike, A., Phillips, C., Niesen, F., Shrestha, L., Burgess-Brown, N., Bullock, A., Berridge, G., von Delft, F., Edwards, A.M., Bountra, C., Arrowsmith, C.H., Weigelt, J., Knapp, S.
Deposit date:2008-11-28
Release date:2009-01-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Crystal Structure of Human Camk4 in Complex with 4-Amino(Sulfamoyl-Phenylamino)-Triazole- Carbothioic Acid (2,6-Difluoro-Phenyl)-Amide)
To be Published
2WA0
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CRYSTAL STRUCTURE OF THE HUMAN MAGEA4
Descriptor:MELANOMA-ASSOCIATED ANTIGEN 4
Authors:Roos, A.K., Cooper, C.D.O., Ugochukwu, E., W Yue, W., Berridge, G., Elkins, J.M., Pike, A.C.W., Bray, J., Filippakopoulos, P., Muniz, J., Chaikuad, A., Burgess-Brown, N., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., von Delft, F., Gileadi, O., Oppermann, U.
Deposit date:2009-01-31
Release date:2009-03-10
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding.
Plos One, 11, 2016
2WEL
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CRYSTAL STRUCTURE OF SU6656-BOUND CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II DELTA IN COMPLEX WITH CALMODULIN
Descriptor:CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN, CALMODULIN, (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE, ...
Authors:Pike, A.C.W., Rellos, P., Salah, E., Burgess-Brown, N., Keates, T., Muniz, J., Sethi, R., Roos, A., Filippakopoulos, P., von Delft, F., Edwards, A., Weigelt, J., Arrowsmith, C.H., Bountra, C., Knapp, S.
Deposit date:2009-03-31
Release date:2009-04-14
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the Camkiidelta/Calmodulin Complex Reveals the Molecular Mechanism of Camkii Kinase Activation.
Plos Biol., 8, 2010