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1HQ0
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF E.COLI CYTOTOXIC NECROTIZING FACTOR TYPE 1
分子名称:CYTOTOXIC NECROTIZING FACTOR 1, PHOSPHATE ION
著者Buetow, L., Flatau, G., Chiu, K., Boquet, P., Ghosh, P.
登録日2000-12-13
公開日2001-07-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Structure of the Rho-activating domain of Escherichia coli cytotoxic necrotizing factor 1.
Nat.Struct.Biol., 8, 2001
1HZG
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CRYSTAL STRUCTURE OF THE INACTIVE C866S MUTANT OF THE CATALYTIC DOMAIN OF E. COLI CYTOTOXIC NECROTIZING FACTOR 1
分子名称:CYTOTOXIC NECROTIZING FACTOR 1, PHOSPHATE ION
著者Buetow, L., Flatau, G., Chiu, K., Boquet, P., Ghosh, P.
登録日2001-01-24
公開日2001-07-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Structure of the Rho-activating domain of Escherichia coli cytotoxic necrotizing factor 1.
Nat.Struct.Biol., 8, 2001
2IU8
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CHLAMYDIA TRACHOMATIS LPXD WITH 25MM UDPGLCNAC (COMPLEX I)
分子名称:UDP-3-O-[3-HYDROXYMYRISTOYL] GLUCOSAMINE N-ACYLTRANSFERASE, SULFATE ION, PALMITIC ACID, ...
著者Buetow, L., Smith, T.K., Dawson, A., Fyffe, S., Hunter, W.N.
登録日2006-05-30
公開日2007-02-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure and Reactivity of Lpxd, the N-Acyltransferase of Lipid a Biosynthesis
Proc.Natl.Acad.Sci.USA, 104, 2007
2IU9
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CHLAMYDIA TRACHOMATIS LPXD WITH 100MM UDPGLCNAC (COMPLEX II)
分子名称:UDP-3-O-[3-HYDROXYMYRISTOYL] GLUCOSAMINE N-ACYLTRANSFERASE, BETA-MERCAPTOETHANOL, SULFATE ION, ...
著者Buetow, L., Smith, T.K., Dawson, A., Fyffe, S., Hunter, W.N.
登録日2006-05-30
公開日2007-02-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure and Reactivity of Lpxd, the N-Acyltransferase of Lipid a Biosynthesis
Proc.Natl.Acad.Sci.USA, 104, 2007
2IUA
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C. TRACHOMATIS LPXD
分子名称:UDP-3-O-[3-HYDROXYMYRISTOYL] GLUCOSAMINE N-ACYLTRANSFERASE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SULFATE ION, ...
著者Buetow, L., Smith, T.K., Dawson, A., Fyffe, S., Hunter, W.N.
登録日2006-05-30
公開日2007-02-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure and Reactivity of Lpxd, the N-Acyltransferase of Lipid a Biosynthesis
Proc.Natl.Acad.Sci.USA, 104, 2007
2J65
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STRUCTURE OF LPXC FROM AQUIFEX AEOLICUS IN COMPLEX WITH UDP
分子名称:UDP-3-O-[3-HYDROXYMYRISTOYL] N-ACETYLGLUCOSAMINE DEACETYLASE, ZINC ION, CHLORIDE ION, ...
著者Buetow, L., Dawson, A., Hunter, W.N.
登録日2006-09-26
公開日2006-11-08
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The Nucleotide-Binding Site of Aquifex Aeolicus Lpxc.
Acta Crystallogr.,Sect.F, 62, 2006
2UZH
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MYCOBACTERIUM SMEGMATIS 2C-METHYL-D-ERYTHRITOL-2,4-CYCLODIPHOSPHATE SYNTHASE (ISPF)
分子名称:2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE, ZINC ION, CYTIDINE-5'-DIPHOSPHATE, ...
著者Buetow, L., Brown, A.C., Parish, T., Hunter, W.N.
登録日2007-04-27
公開日2007-11-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The Structure of Mycobacteria 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase, an Essential Enzyme, Provides a Platform for Drug Discovery.
Bmc Struct.Biol., 7, 2007
4V3K
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RNF38-UBCH5B-UB COMPLEX
分子名称:UBIQUITIN-CONJUGATING ENZYME E2 D2, POLYUBIQUITIN-C, E3 UBIQUITIN-PROTEIN LIGASE RNF38, ...
著者Buetow, L., Gabrielsen, M., Anthony, N.G., Dou, H., Patel, A., Aitkenhead, H., Sibbet, G.J., Smith, B.O., Huang, D.T.
登録日2014-10-20
公開日2015-04-08
最終更新日2019-07-31
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin.
Mol.Cell, 58, 2015
4V3L
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RNF38-UB-UBCH5B-UB COMPLEX
分子名称:UBIQUITIN-CONJUGATING ENZYME E2 D2, POLYUBIQUITIN-C, E3 UBIQUITIN-PROTEIN LIGASE RNF38, ...
著者Buetow, L., Gabrielsen, M., Anthony, N.G., Dou, H., Patel, A., Aitkenhead, H., Sibbet, G.J., Smith, B.O., Huang, D.T.
登録日2014-10-20
公開日2015-04-08
最終更新日2019-07-31
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin.
Mol.Cell, 58, 2015
5J3X
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STRUCTURE OF C-CBL Y371F
分子名称:E3 ubiquitin-protein ligase CBL, ZINC ION, CALCIUM ION
著者Huang, D.T., Buetow, L., Dou, H.
登録日2016-03-31
公開日2016-09-21
実験手法X-RAY DIFFRACTION (2.822 Å)
主引用文献Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation.
Bmc Biol., 14, 2016
2AWH
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HUMAN NUCLEAR RECEPTOR-LIGAND COMPLEX 1
分子名称:Peroxisome proliferator activated receptor delta, HEPTYL-BETA-D-GLUCOPYRANOSIDE, VACCENIC ACID
著者Fyffe, S.A., Alphey, M.S., Buetow, L., Smith, T.K., Ferguson, M.A.J., Sorensen, M.D., Bjorkling, F., Hunter, W.N.
登録日2005-09-01
公開日2006-02-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Recombinant Human PPAR-beta/delta Ligand-binding Domain is Locked in an Activated Conformation by Endogenous Fatty Acids
J.Mol.Biol., 356, 2006
2B50
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HUMAN NUCLEAR RECEPTOR-LIGAND COMPLEX 2
分子名称:Peroxisome proliferator activated receptor delta, CALCIUM ION, HEPTYL-BETA-D-GLUCOPYRANOSIDE, ...
著者Fyffe, S.A., Alphey, M.S., Buetow, L., Smith, T.K., Ferguson, M.A.J., Sorensen, M.D., Bjorkling, F., Hunter, W.N.
登録日2005-09-27
公開日2006-02-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Recombinant Human PPAR-beta/delta Ligand-binding Domain is Locked in an Activated Conformation by Endogenous Fatty Acids
J.Mol.Biol., 356, 2006
2BAW
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HUMAN NUCLEAR RECEPTOR-LIGAND COMPLEX 1
分子名称:Peroxisome proliferator activated receptor delta, HEPTYL-BETA-D-GLUCOPYRANOSIDE, VACCENIC ACID
著者Fyffe, S.A., Alphey, M.S., Buetow, L., Smith, T.K., Ferguson, M.A.J., Sorensen, M.D., Bjorkling, F., Hunter, W.N.
登録日2005-10-15
公開日2006-01-24
最終更新日2011-09-28
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Reevaluation of the PPAR-beta/delta Ligand Binding Domain Model Reveals Why It Exhibits the Activated Form
Mol.Cell, 21, 2006
2JF2
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NUCLEOTIDE SUBSTRATE BINDING BY UDP-N-ACETYLGLUCOSAMINE ACYLTRANSFERASE
分子名称:ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE, DI(HYDROXYETHYL)ETHER, 1,2-ETHANEDIOL
著者Ulaganathan, V., Buetow, L., Hunter, W.N.
登録日2007-01-25
公開日2007-04-24
最終更新日2013-12-04
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Nucleotide Substrate Recognition by Udp-N-Acetylglucosamine Acyltransferase (Lpxa) in the First Step of Lipid a Biosynthesis.
J.Mol.Biol., 369, 2007
2JF3
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NUCLEOTIDE SUBSTRATE BINDING BY UDP-N-ACETYLGLUCOSAMINE ACYLTRANSFERASE
分子名称:ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE
著者Ulaganathan, V., Buetow, L., Hunter, W.N.
登録日2007-01-25
公開日2007-04-24
最終更新日2013-12-04
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Nucleotide Substrate Recognition by Udp-N-Acetylglucosamine Acyltransferase (Lpxa) in the First Step of Lipid a Biosynthesis.
J.Mol.Biol., 369, 2007
2UZF
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS 1,4-DIHYDROXY-2-NAPHTHOYL COA SYNTHASE (MENB) IN COMPLEX WITH ACETOACETYL COA
分子名称:NAPHTHOATE SYNTHASE, ACETOACETYL-COENZYME A
著者Ulaganathan, V., Buetow, L., Hunter, W.N.
登録日2007-04-27
公開日2007-11-13
最終更新日2012-06-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of Staphylococcus Aureus1,4-Dihydroxy-2-Naphthoyl-Coa Synthase (Menb) in Complex with Acetoacetyl-Coa.
Acta Crystallogr.,Sect.F, 63, 2007
3ZNI
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STRUCTURE OF PHOSPHOTYR363-CBL-B - UBCH5B-UB - ZAP-70 PEPTIDE COMPLEX
分子名称:E3 UBIQUITIN-PROTEIN LIGASE CBL-B, TYROSINE-PROTEIN KINASE ZAP-70, UBIQUITIN-CONJUGATING ENZYME E2 D2, ...
著者Dou, H., Buetow, L., Sibbet, G.J., Cameron, K., Huang, D.T.
登録日2013-02-14
公開日2013-07-10
最終更新日2019-07-31
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Essentiality of a Non-Ring Element in Priming Donor Ubiquitin for Catalysis by a Monomeric E3.
Nat.Struct.Mol.Biol., 20, 2013
4A49
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STRUCTURE OF PHOSPHOTYR371-C-CBL-UBCH5B COMPLEX
分子名称:E3 ubiquitin-protein ligase CBL, Ubiquitin-conjugating enzyme E2 D2, ZINC ION, ...
著者Dou, H., Buetow, L., Hock, A., Sibbet, G.J., Vousden, K.H., Huang, D.T.
登録日2011-10-07
公開日2012-01-25
最終更新日2018-11-21
実験手法X-RAY DIFFRACTION (2.214 Å)
主引用文献Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl.
Nat. Struct. Mol. Biol., 19, 2012
4A4B
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STRUCTURE OF MODIFIED PHOSPHOTYR371-C-CBL-UBCH5B-ZAP-70 COMPLEX
分子名称:E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, UBIQUITIN-CONJUGATING ENZYME E2 D2, ...
著者Dou, H., Buetow, L., Hock, A., Sibbet, G.J., Vousden, K.H., Huang, D.T.
登録日2011-10-08
公開日2012-01-25
最終更新日2012-02-29
実験手法X-RAY DIFFRACTION (2.789 Å)
主引用文献Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl
Nat.Struct.Mol.Biol., 19, 2012
4A4C
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STRUCTURE OF PHOSPHOTYR371-C-CBL-UBCH5B-ZAP-70 COMPLEX
分子名称:E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, UBIQUITIN-CONJUGATING ENZYME E2 D2, ...
著者Dou, H., Buetow, L., Hock, A., Sibbet, G.J., Vousden, K.H., Huang, D.T.
登録日2011-10-08
公開日2012-01-25
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (2.704 Å)
主引用文献Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl
Nat.Struct.Mol.Biol., 19, 2012
4AUQ
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STRUCTURE OF BIRC7-UBCH5B-UB COMPLEX.
分子名称:UBIQUITIN-CONJUGATING ENZYME E2 D2, BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 7, POLYUBIQUITIN-C, ...
著者Dou, H., Buetow, L., Sibbet, G.J., Cameron, K., Huang, D.T.
登録日2012-05-21
公開日2012-08-15
最終更新日2019-07-31
実験手法X-RAY DIFFRACTION (2.176 Å)
主引用文献Birc7-E2 Ubiquitin Conjugate Structure Reveals the Mechanism of Ubiquitin Transfer by a Ring Dimer.
Nat.Struct.Mol.Biol., 19, 2012
5O6S
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UBV.B4R, A DIMERIC UBIQUITIN VARIANT BINDING TO BIRC4 RING
分子名称:Polyubiquitin-B
著者Gabrielsen, M., Buetow, L., Huang, D.T.
登録日2017-06-07
公開日2017-11-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
5O6T
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BIRC4 RING IN COMPLEX WITH DIMERIC UBIQUITIN VARIANT
分子名称:E3 ubiquitin-protein ligase XIAP, Polyubiquitin-B, ZINC ION, ...
著者Gabrielsen, M., Buetow, L., Huang, D.T.
登録日2017-06-07
公開日2017-11-01
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
5O75
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UBE4B U-BOX DOMAIN
分子名称:Ubiquitin conjugation factor E4 B, SULFATE ION
著者Gabrielsen, M., Buetow, L., Nakasone, M.A., Huang, D.T.
登録日2017-06-08
公開日2017-11-01
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.483 Å)
主引用文献A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
5O76
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STRUCTURE OF PHOSPHOY371 C-CBL IN COMPLEX WITH ZAP70-PEPTIDE AND UBV.PCBL UBIQUITIN VARIANT
分子名称:E3 ubiquitin-protein ligase CBL, Tyrosine protein kinase ZAP70 peptide, UbV.pCBL ubiquitin variant, ...
著者Gabrielsen, M., Buetow, L., Huang, D.T.
登録日2017-06-08
公開日2017-11-01
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.473 Å)
主引用文献A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
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