Author results

1B38
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HUMAN CYCLIN-DEPENDENT KINASE 2
Descriptor:PROTEIN (CELL DIVISION PROTEIN KINASE 2), MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Brown, N.R., Noble, M.E.M., Lawrie, A.M., Morris, M.C., Tunnah, P., Divita, G., Johnson, L.N., Endicott, J.A.
Deposit date:1998-12-17
Release date:1998-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity.
J.Biol.Chem., 274, 1999
1B39
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HUMAN CYCLIN-DEPENDENT KINASE 2 PHOSPHORYLATED ON THR 160
Descriptor:PROTEIN (CELL DIVISION PROTEIN KINASE 2), MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Brown, N.R., Noble, M.E.M., Lawrie, A.M., Morris, M.C., Tunnah, P., Divita, G., Johnson, L.N., Endicott, J.A.
Deposit date:1998-12-17
Release date:1998-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity.
J.Biol.Chem., 274, 1999
1QMZ
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PHOSPHORYLATED CDK2-CYCLYIN A-SUBSTRATE PEPTIDE COMPLEX
Descriptor:CELL DIVISION PROTEIN KINASE 2, G2/MITOTIC-SPECIFIC CYCLIN A, SUBSTRATE PEPTIDE, ...
Authors:Brown, N.R., Noble, M.E.M., Endicott, J.A., Johnson, L.N.
Deposit date:1999-10-11
Release date:1999-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Structural Basis for Specificity of Substrate and Recruitment Peptides for Cyclin-Dependent Kinases
Nat.Cell Biol., 1, 1999
2JGZ
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CRYSTAL STRUCTURE OF PHOSPHO-CDK2 IN COMPLEX WITH CYCLIN B
Descriptor:CELL DIVISION PROTEIN KINASE 2, G2/MITOTIC-SPECIFIC CYCLIN-B1
Authors:Brown, N.R., Petri, E., Lowe, E.D., Skamnaki, V., Johnson, L.N.
Deposit date:2007-02-17
Release date:2007-05-22
Last modified:2019-10-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Cyclin B and cyclin A confer different substrate recognition properties on CDK2.
Cell Cycle, 6, 2007
4Y72
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HUMAN CDK1/CYCLINB1/CKS2 WITH INHIBITOR
Descriptor:Cyclin-dependent kinase 1, G2/mitotic-specific cyclin-B1, Cyclin-dependent kinases regulatory subunit 2, ...
Authors:Brown, N.R., Korolchuk, S., Martin, M.P., Stanley, W., Moukhametzianov, R., Noble, M.E.M., Endicott, J.A.
Deposit date:2015-02-13
Release date:2015-08-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
4YC3
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CDK1/CYCLINB1/CKS2 APO
Descriptor:Cyclin-dependent kinase 1, G2/mitotic-specific cyclin-B1, Cyclin-dependent kinases regulatory subunit 2, ...
Authors:Brown, N.R., Korolchuk, S., Martin, M.P., Stanley, W., Moukhametzianov, R., Noble, M.E.M., Endicott, J.A.
Deposit date:2015-02-19
Release date:2016-04-20
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
4YC6
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CDK1/CKS1
Descriptor:Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 1
Authors:Brown, N.R., Korolchuk, S., Martin, M.P., Stanley, W., Moukhametzianov, R., Noble, M.E.M., Endicott, J.A.
Deposit date:2015-02-19
Release date:2015-05-20
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
1VIN
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BOVINE CYCLIN A3
Descriptor:CYCLIN A
Authors:Noble, M.E.M., Endicott, J.A.E., Brown, N.R.
Deposit date:1996-03-15
Release date:1996-08-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of cyclin A.
Structure, 3, 1995
5HQ0
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TERNARY COMPLEX OF HUMAN PROTEINS CDK1, CYCLIN B AND CKS2, BOUND TO AN INHIBITOR
Descriptor:Cyclin-dependent kinase 1, G2/mitotic-specific cyclin-B1, Cyclin-dependent kinases regulatory subunit 2, ...
Authors:Noble, M.E., Martin, M.P., Korolchuk, S., Brown, N.R., Moukhametzianov, R., Stanley, W.A.
Deposit date:2016-01-21
Release date:2016-03-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
1H24
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CDK2/CYCLINA IN COMPLEX WITH A 9 RESIDUE RECRUITMENT PEPTIDE FROM E2F
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, TRANSCRIPTION FACTOR E2F1
Authors:Tews, I., Cheng, K.Y., Lowe, E.D., Noble, M.E.M., Brown, N.R., Gul, S., Gamblin, S., Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H25
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CDK2/CYCLIN A IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM RETINOBLASTOMA-ASSOCIATED PROTEIN
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, RETINOBLASTOMA-ASSOCIATED PROTEIN
Authors:Tews, I., Cheng, K.Y., Lowe, E.D., Noble, M.E.M., Brown, N.R., Gul, S., Gamblin, S., Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H26
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CDK2/CYCLINA IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM P53
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, CELLULAR TUMOR ANTIGEN P53
Authors:Tews, I., Cheng, K.Y., Lowe, E.D., Noble, M.E.M., Brown, N.R., Gul, S., Gamblin, S., Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H27
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CDK2/CYCLINA IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM P27
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, CYCLIN-DEPENDENT KINASE INHIBITOR 1B
Authors:Tews, I., Cheng, K.Y., Lowe, E.D., Noble, M.E.M., Brown, N.R., Gul, S., Gamblin, S., Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H28
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CDK2/CYCLINA IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM P107
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, RETINOBLASTOMA-LIKE PROTEIN 1
Authors:Tews, I., Cheng, K.Y., Lowe, E.D., Noble, M.E.M., Brown, N.R., Gul, S., Gamblin, S., Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1PKD
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THE CRYSTAL STRUCTURE OF UCN-01 IN COMPLEX WITH PHOSPHO-CDK2/CYCLIN A
Descriptor:Cell division protein kinase 2, Cyclin A2, 7-HYDROXYSTAUROSPORINE
Authors:Johnson, L.N., De Moliner, E., Brown, N.R., Song, H.
Deposit date:2003-06-05
Release date:2003-06-24
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Crystal Structure of UCN-01 in Complex with Phospho-CDK2/Cyclin A
To be Published
1AQ1
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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE
Descriptor:CYCLIN-DEPENDENT PROTEIN KINASE 2, STAUROSPORINE
Authors:Endicott, J.A., Noble, M.E.M., Johnson, L.N., Lawrie, A., Tunnah, P., Brown, N.R.
Deposit date:1997-08-05
Release date:1997-11-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.
Nat.Struct.Biol., 4, 1997
1FPZ
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CRYSTAL STRUCTURE ANALYSIS OF KINASE ASSOCIATED PHOSPHATASE (KAP) WITH A SUBSTITUTION OF THE CATALYTIC SITE CYSTEINE (CYS140) TO A SERINE
Descriptor:CYCLIN-DEPENDENT KINASE INHIBITOR 3, SULFATE ION
Authors:Song, H., Hanlon, N., Brown, N.R., Noble, M.E.M., Johnson, L.N., Barford, D.
Deposit date:2000-09-01
Release date:2001-05-09
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2.
Mol.Cell, 7, 2001
1FQ1
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CRYSTAL STRUCTURE OF KINASE ASSOCIATED PHOSPHATASE (KAP) IN COMPLEX WITH PHOSPHO-CDK2
Descriptor:CYCLIN-DEPENDENT KINASE INHIBITOR 3, CELL DIVISION PROTEIN KINASE 2, MAGNESIUM ION, ...
Authors:Song, H., Hanlon, N., Brown, N.R., Noble, M.E.M., Johnson, L.N., Barford, D.
Deposit date:2000-09-01
Release date:2001-05-09
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2.
Mol.Cell, 7, 2001
1P5E
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THE STRUCTURE OF PHOSPHO-CDK2/CYCLIN A IN COMPLEX WITH THE INHIBITOR 4,5,6,7-TETRABROMOBENZOTRIAZOLE (TBS)
Descriptor:Cell division protein kinase 2, Cyclin A2, 4,5,6,7-TETRABROMOBENZOTRIAZOLE
Authors:De Moliner, E., Brown, N.R., Johnson, L.N.
Deposit date:2003-04-26
Release date:2003-07-01
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Alternative binding modes of an inhibitor to two different kinases
Eur.J.Biochem., 270, 2003
1UA2
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CRYSTAL STRUCTURE OF HUMAN CDK7
Descriptor:Cell division protein kinase 7, ADENOSINE-5'-TRIPHOSPHATE
Authors:Lolli, G., Lowe, E.D., Brown, N.R., Johnson, L.N.
Deposit date:2004-08-11
Release date:2004-12-07
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:The Crystal Structure of Human CDK7 and Its Protein Recognition Properties
Structure, 12, 2004
1Z96
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CRYSTAL STRUCTURE OF THE MUD1 UBA DOMAIN
Descriptor:UBA-domain protein mud1
Authors:Trempe, J.-F., Brown, N.R., Lowe, E.D., Noble, M.E.M., Gordon, C., Campbell, I.D., Johnson, L.N., Endicott, J.A.
Deposit date:2005-03-31
Release date:2005-10-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain
Embo J., 24, 2005
2BWB
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CRYSTAL STRUCTURE OF THE UBA DOMAIN OF DSK2 FROM S. CEREVISIAE
Descriptor:UBIQUITIN-LIKE PROTEIN DSK2
Authors:Lowe, E.D., Hasan, N., Trempe, J.-F., Fonso, L., Noble, M.E.M., Endicott, J.A., Johnson, L.N., Brown, N.R.
Deposit date:2005-07-13
Release date:2006-01-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the Dsk2 Ubl and Uba Domains and Their Complex.
Acta Crystallogr.,Sect.D, 62, 2006
2BWE
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THE CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE UBA AND UBL DOMAINS OF DSK2
Descriptor:DSK2
Authors:Lowe, E.D., Hasan, N., Trempe, J.-F., Fonso, L., Noble, M.E.M., Endicott, J.A., Johnson, L.N., Brown, N.R.
Deposit date:2005-07-13
Release date:2006-01-25
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structures of the Dsk2 Ubl and Uba Domains and Their Complex.
Acta Crystallogr.,Sect.D, 62, 2006
2BWF
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CRYSTAL STURCTURE OF THE UBL DOMAIN OF DSK2 FROM S. CEREVISIAE
Descriptor:UBIQUITIN-LIKE PROTEIN DSK2, FORMIC ACID
Authors:Lowe, E.D., Hasan, N., Trempe, J.-F., Fonso, L., Noble, M.E.M., Endicott, J.A., Johnson, L.N., Brown, N.R.
Deposit date:2005-07-13
Release date:2006-01-25
Last modified:2015-04-15
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Structures of the Dsk2 Ubl and Uba Domains and Their Complex.
Acta Crystallogr.,Sect.D, 62, 2006
2CCH
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THE CRYSTAL STRUCTURE OF CDK2 CYCLIN A IN COMPLEX WITH A SUBSTRATE PEPTIDE DERIVED FROM CDC MODIFIED WITH A GAMMA-LINKED ATP ANALOGUE
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, CELL DIVISION CONTROL PROTEIN 6 HOMOLOG, ...
Authors:Cheng, K.Y., Noble, M.E.M., Skamnaki, V., Brown, N.R., Lowe, E.D., Kontogiannis, L., Shen, K., Cole, P.A., Siligardi, G., Johnson, L.N.
Deposit date:2006-01-16
Release date:2006-05-03
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Role of the Phospho-Cdk2/Cyclin a Recruitment Site in Substrate Recognition
J.Biol.Chem., 281, 2006
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