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3QE0
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A GALPHA-I1 P-LOOP MUTATION PREVENTS TRANSITION TO THE ACTIVATED STATE
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, KB752 peptide, MAGNESIUM ION, ...
Authors:Bosch, D.E., Willard, F.S., Kimple, A.J., Miley, M.J., Siderovski, D.P.
Deposit date:2011-01-19
Release date:2012-01-25
Last modified:2012-03-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis
Plos Pathog., 8, 2012
3QI2
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A GALPHA P-LOOP MUTATION PREVENTS TRANSITION TO THE ACTIVATED STATE: G42R BOUND TO RGS14 GOLOCO
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Bosch, D.E., Willard, F.S., Kimple, A.J., Miley, M.J., Siderovski, D.P.
Deposit date:2011-01-26
Release date:2012-02-01
Last modified:2012-03-14
Method:X-RAY DIFFRACTION (2.797 Å)
Cite:A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis
Plos Pathog., 8, 2012
3REF
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CRYSTAL STRUCTURE OF EHRHO1 BOUND TO GDP AND MAGNESIUM
Descriptor:Rho-like small GTPase, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Bosch, D.E., Qiu, C., Siderovski, D.P.
Deposit date:2011-04-04
Release date:2011-09-28
Last modified:2012-03-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Unique structural and nucleotide exchange features of the Rho1 GTPase of Entamoeba histolytica.
J.Biol.Chem., 286, 2011
3REG
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CRYSTAL STRUCTURE OF EHRHO1 BOUND TO A GTP ANALOG AND MAGNESIUM
Descriptor:Rho-like small GTPase, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION
Authors:Bosch, D.E., Qiu, C., Siderovski, D.P.
Deposit date:2011-04-04
Release date:2011-09-28
Last modified:2012-03-14
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Unique structural and nucleotide exchange features of the Rho1 GTPase of Entamoeba histolytica.
J.Biol.Chem., 286, 2011
4DVG
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CRYSTAL STRUCTURE OF E. HISTOLYTICA FORMIN1 BOUND TO EHRHO1-GTPGAMMAS
Descriptor:Rho-like small GTPase, Diaphanous protein, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ...
Authors:Bosch, D.E., Siderovski, D.P.
Deposit date:2012-02-23
Release date:2012-11-14
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (2.604 Å)
Cite:Entamoeba histolytica Rho1 Regulates Actin Polymerization through a Divergent, Diaphanous-Related Formin.
Biochemistry, 51, 2012
4FID
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CRYSTAL STRUCTURE OF A HETEROTRIMERIC G-PROTEIN SUBUNIT FROM ENTAMOEBA HISTOLYTICA, EHG-ALPHA-1
Descriptor:G protein alpha subunit, GUANOSINE-5'-DIPHOSPHATE
Authors:Bosch, D.E., Kimple, A.J., Muller, R.E., Gigure, P.M., Willard, F.S., Machius, M., Temple, B.R., Siderovski, D.P.
Deposit date:2012-06-08
Release date:2012-11-28
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica.
Plos Pathog., 8, 2012
4GOU
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CRYSTAL STRUCTURE OF AN RGS-RHOGEF FROM ENTAMOEBA HISTOLYTICA
Descriptor:EhRGS-RhoGEF
Authors:Bosch, D.E., Kimple, A.J., Muller, R.E., Willard, F.S., Machius, M., Siderovski, D.P.
Deposit date:2012-08-20
Release date:2013-01-09
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Determinants of RGS-RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis.
Structure, 21, 2013
4GPR
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CRYSTAL STRUCTURE OF EHUBC5, A UBIQUITIN CONJUGATING ENZYME FROM ENTAMOEBA HISTOLYTICA
Descriptor:Ubiquitin-conjugating enzyme family protein, COBALT (II) ION
Authors:Bosch, D.E., Siderovski, D.P.
Deposit date:2012-08-21
Release date:2012-12-12
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Determinants of Ubiquitin Conjugation in Entamoeba histolytica.
J.Biol.Chem., 288, 2013
4GSW
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CRYSTAL STRUCTURE OF UBIQUITIN FROM ENTAMOEBA HISTOLYTICA TO 2.15 ANGSTROM
Descriptor:Ubiquitin, SULFATE ION
Authors:Bosch, D.E., Siderovski, D.P.
Deposit date:2012-08-28
Release date:2012-12-12
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural Determinants of Ubiquitin Conjugation in Entamoeba histolytica.
J.Biol.Chem., 288, 2013
4GU2
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CRYSTAL STRUCTURE OF UBIQUITIN FROM ENTAMOEBA HISTOLYTICA TO 1.35 ANGSTROM
Descriptor:Ubiquitin
Authors:Bosch, D.E., Siderovski, D.P.
Deposit date:2012-08-29
Release date:2012-12-12
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural Determinants of Ubiquitin Conjugation in Entamoeba histolytica.
J.Biol.Chem., 288, 2013
4MIT
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CRYSTAL STRUCTURE OF E. HISTOLYTICA RACC BOUND TO THE EHPAK4 PBD
Descriptor:Rho family GTPase, Serine/threonine protein kinase PAK, putative, ...
Authors:Bosch, D.E., Siderovski, D.P.
Deposit date:2013-09-02
Release date:2014-09-03
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Entamoeba histolytica RacC Selectively Engages p21-Activated Kinase Effectors.
Biochemistry, 54, 2015
6DRE
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ADP-RIBOSYLTRANSFERASE TOXIN/IMMUNITY PAIR
Descriptor:ADP-ribosyl-(Dinitrogen reductase) hydrolase, PAAR repeat-containing protein, MAGNESIUM ION
Authors:Bosch, D.E., Ting, S., Allaire, M., Mougous, J.D.
Deposit date:2018-06-11
Release date:2018-10-31
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Bifunctional Immunity Proteins Protect Bacteria against FtsZ-Targeting ADP-Ribosylating Toxins.
Cell, 175, 2018
6DRH
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ADP-RIBOSYLTRANSFERASE TOXIN/IMMUNITY PAIR
Descriptor:ADP-ribosyl-(Dinitrogen reductase) hydrolase, PAAR repeat-containing protein, PHOSPHATE ION, ...
Authors:Bosch, D.E., Ting, S., Allaire, M., Mougous, J.D.
Deposit date:2018-06-11
Release date:2018-10-31
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.299 Å)
Cite:Bifunctional Immunity Proteins Protect Bacteria against FtsZ-Targeting ADP-Ribosylating Toxins.
Cell, 175, 2018
3ONW
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STRUCTURE OF A G-ALPHA-I1 MUTANT WITH ENHANCED AFFINITY FOR THE RGS14 GOLOCO MOTIF.
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Bosch, D., Kimple, A.J., Sammond, D.W., Miley, M.J., Machius, M., Kuhlman, B., Willard, F.S., Siderovski, D.P.
Deposit date:2010-08-30
Release date:2010-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein {alpha} Subunit Mutants.
J.Biol.Chem., 286, 2011
2XNS
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CRYSTAL STRUCTURE OF HUMAN G ALPHA I1 BOUND TO A DESIGNED HELICAL PEPTIDE DERIVED FROM THE GOLOCO MOTIF OF RGS14
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-1, REGULATOR OF G-PROTEIN SIGNALING 14, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Bosch, D., Sammond, D.W., Butterfoss, G.L., Machius, M., Siderovski, D.P., Kuhlman, B.
Deposit date:2010-08-05
Release date:2011-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:Computational Design of the Sequence and Structure of a Protein-Binding Peptide.
J.Am.Chem.Soc., 133, 2011