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4JLF
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INHIBITOR RESISTANT (R220A) SUBSTITUTION IN THE MYCOBACTERIUM TUBERCULOSIS BETA-LACTAMASE
Descriptor:Beta-lactamase, PHOSPHATE ION
Authors:Hazra, S., Kurz, S., Blanchard, J., Bonomo, R.
Deposit date:2013-03-12
Release date:2013-10-30
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis beta-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of beta-lactam-beta-lactamase inhibitor combinations.
Antimicrob.Agents Chemother., 57, 2013
6C6I
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CRYSTAL STRUCTURE OF A CHIMERIC NDM-1 METALLO-BETA-LACTAMASE HARBORING THE IMP-1 L3 LOOP
Descriptor:Metallo-beta-lactamase type 2 chimera, ZINC ION
Authors:Otero, L., Giannini, E., Klinke, S., Palacios, A., Mojica, M., Bonomo, R., Llarrull, L., Vila, A.
Deposit date:2018-01-18
Release date:2018-10-17
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The Reaction Mechanism of Metallo-beta-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop.
Antimicrob. Agents Chemother., 63, 2019
6CAC
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CRYSTAL STRUCTURE OF NDM-1 METALLO-BETA-LACTAMASE HARBORING AN INSERTION OF A PRO RESIDUE IN L3 LOOP
Descriptor:Metallo-beta-lactamase type 2, ZINC ION, CADMIUM ION, ...
Authors:Alzari, P.M., Giannini, E., Palacios, A., Mojica, M., Bonomo, R., Llarrull, L., Vila, A.
Deposit date:2018-01-30
Release date:2018-10-17
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:The Reaction Mechanism of Metallo-beta-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop.
Antimicrob. Agents Chemother., 63, 2019