6DGU

PER-2 class A extended-spectrum beta-lactamase crystal structure at 2.69 Angstrom resolution

Summary for 6DGU

DescriptorBeta-lactamase (2 entities in total)
Functional Keywordspenicilloil-serine-transferase, antibiotic resistance, hydrolase
Biological sourceCitrobacter freundii
Total number of polymer chains4
Total molecular weight122680.16
Authors
Power, P.,Ruggiero, M.,Gutkind, G.,Bonomo, R.,Klinke, S. (deposition date: 2018-05-18, release date: 2019-05-22, Last modification date: 2020-06-03)
Primary citation
Ruggiero, M.,Papp-Wallace, K.M.,Brunetti, F.,Barnes, M.D.,Bonomo, R.A.,Gutkind, G.,Klinke, S.,Power, P.
Structural Insights into the Inhibition of the Extended-Spectrum beta-Lactamase PER-2 by Avibactam.
Antimicrob.Agents Chemother., 63:-, 2019
PubMed: 31235626 (PDB entries with the same primary citation)
DOI: 10.1128/AAC.00487-19
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.691 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.34016 0.4% 1.4% 2.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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