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7PUR
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BU of 7pur by Molmil
mouse Interleukin-12 subunit beta - p80 homodimer in space group P21 crystal form 2
Descriptor: Interleukin-12 subunit beta, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2021-09-30
Release date:2021-11-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Around she goes: the structure of mouse Interleukin-12 p80
To Be Published
7R3N
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BU of 7r3n by Molmil
mouse Interleukin-12 subunit beta - p80 homodimer in space group P21 crystal form 3
Descriptor: Interleukin-12 subunit beta, PHOSPHATE ION, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2022-02-07
Release date:2022-05-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Around she goes: the structure of mouse Interleukin-12 p80
To Be Published
5MXA
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BU of 5mxa by Molmil
Structure of unbound Interleukin-23
Descriptor: Interleukin-12 subunit beta, Interleukin-23 subunit alpha, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2017-01-22
Release date:2017-12-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12R beta 1.
Immunity, 48, 2018
7PNN
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BU of 7pnn by Molmil
mVenus released from fusion protein.
Descriptor: CHLORIDE ION, mVenus
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2021-09-07
Release date:2021-11-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:mVenus released from fusion protein.
To Be Published
6SMC
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BU of 6smc by Molmil
mouse Interleukin-12 subunit beta - p80 homodimer in space group P1
Descriptor: CHLORIDE ION, Interleukin-12 subunit beta, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2019-08-21
Release date:2020-09-09
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Around she goes: the structure of mouse Interleukin-12 p80
To Be Published
6SP3
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BU of 6sp3 by Molmil
mouse Interleukin-12 subunit beta - p80 homodimer in space group P21 crystal form 1
Descriptor: CHLORIDE ION, Interleukin-12 subunit beta, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2019-08-30
Release date:2020-09-09
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Around she goes: the structure of mouse Interleukin-12 p80
To Be Published
5MZV
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BU of 5mzv by Molmil
IL-23:IL-23R:Nb22E11 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2017-02-01
Release date:2018-01-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12R beta 1.
Immunity, 48, 2018
5N2K
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BU of 5n2k by Molmil
Structure of unbound Briakinumab FAb
Descriptor: 1,2-ETHANEDIOL, Briakinumab FAb heavy chain, Briakinumab FAb light chain
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2017-02-07
Release date:2018-01-03
Last modified:2020-03-11
Method:X-RAY DIFFRACTION (2.219 Å)
Cite:Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12R beta 1.
Immunity, 48, 2018
5NJD
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BU of 5njd by Molmil
Structure of Interleukin 23 in complex with Briakinumab FAb
Descriptor: Briakinumab FAb Heavy chain, Briakinumab FAb Light chain, Interleukin-12 subunit beta, ...
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2017-03-28
Release date:2018-01-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12R beta 1.
Immunity, 48, 2018
8C7L
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BU of 8c7l by Molmil
Serendipitous structure of OmpF contaminant in space group P21.
Descriptor: Outer membrane porin F
Authors:Bloch, Y, Theunissen, S, Savvides, S.N.
Deposit date:2023-01-16
Release date:2023-02-22
Method:X-RAY DIFFRACTION (3.52 Å)
Cite:Serendipitous structure of OmpF contaminant in space group P21.
To Be Published
8C7E
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BU of 8c7e by Molmil
Serendipitous cyanase structure from Serratia-like contamination
Descriptor: CHLORIDE ION, Cyanate hydratase
Authors:Bloch, Y, Skladanowska, K, Savvides, S.N.
Deposit date:2023-01-14
Release date:2023-02-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Serendipitous cyanase structure from Serratia-like contamination.
To Be Published
8C6Z
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BU of 8c6z by Molmil
necrotic enteritis associated Clostridium p. chitinase F8UNI4 in complex with inhibitor bisdionin C
Descriptor: 1,1'-PROPANE-1,3-DIYLBIS(3,7-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE), CADMIUM ION, COBALT (II) ION, ...
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2023-01-12
Release date:2023-05-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Contribution and structural characterization of Chitinases to Clostridium perfringens Pathogenesis in Broilers
To Be Published
8C7M
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BU of 8c7m by Molmil
Interleukin 12 receptor subunit beta-1 Fn domains in complex with antagonistic FAb fragment.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, FAb4 Crystal Kappa Light chain, ...
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2023-01-16
Release date:2024-01-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 2024
8CR8
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BU of 8cr8 by Molmil
human Interleukin-23
Descriptor: Interleukin-12 subunit beta, Interleukin-23 subunit alpha, TERBIUM(III) ION, ...
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2023-03-08
Release date:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 2024
8OSE
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BU of 8ose by Molmil
C. perfringens chitinase CP4_3455 in complex with inhibitor bisdionin C
Descriptor: 1,1'-PROPANE-1,3-DIYLBIS(3,7-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE), 1,2-ETHANEDIOL, Chitodextrinase, ...
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2023-04-18
Release date:2023-07-12
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:C. perfringens chitinase CP4_3455 in complex with inhibitor bisdionin C
To Be Published
8OTB
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BU of 8otb by Molmil
Clostridium perfringens chitinase CP4_3455
Descriptor: CHLORIDE ION, Chitodextrinase, DI(HYDROXYETHYL)ETHER, ...
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2023-04-20
Release date:2023-07-12
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Clostridium perfringens chitinase CP4_3455
To Be Published
8ODX
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BU of 8odx by Molmil
Interleukin 12 receptor subunit beta-1 Fn domains in complex with antagonistic FAb4 fragment and VHH.
Descriptor: FAb4 Heavy chain, FAb4 Light chain, Interleukin-12 receptor subunit beta-1, ...
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2023-03-09
Release date:2024-02-07
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 2024
8OE4
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BU of 8oe4 by Molmil
Cryo-EM structure of a pre-dimerized human IL-23 complete extracellular signaling complex.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ...
Authors:Bloch, Y, Felix, J, Savvides, S.N.
Deposit date:2023-03-10
Release date:2024-02-07
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 2024
8OWF
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BU of 8owf by Molmil
Clostridium perfringens chitinase CP4_3455 with chitosan
Descriptor: 2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Chitodextrinase, ...
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2023-04-27
Release date:2023-07-12
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Clostridium perfringens chitinase CP4_3455 with chitosan
To Be Published
8OYE
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BU of 8oye by Molmil
Clostridium perfringens chitinase CP4_3455 E196Q with chitin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chitodextrinase, DIMETHYL SULFOXIDE
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2023-05-04
Release date:2023-07-12
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Clostridium perfringens chitinase CP4_3455 E196Q with chitin
To Be Published
8OVR
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BU of 8ovr by Molmil
Clostridium perfringens chitinase CP56_3454 apo form
Descriptor: Chitinase B, PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID), SODIUM ION, ...
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2023-04-26
Release date:2023-07-12
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Clostridium perfringens chitinase CP56_3454 apo form
To Be Published
8PPM
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BU of 8ppm by Molmil
IL-12Rb1 neutralizing Fab4, crystal kappa variant
Descriptor: Fab4 Light chain, crystal kappa variant, Fab4 heavy chain, ...
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2023-07-07
Release date:2024-02-07
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 2024
8QMG
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BU of 8qmg by Molmil
Tobacco lectin Nictaba in apo state including I and Eu SAD datasets.
Descriptor: Nictaba, ZINC ION
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2023-09-22
Release date:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Tobacco lectin Nictaba in apo state including I and Eu SAD datasets.
To Be Published
8AD2
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BU of 8ad2 by Molmil
Tobacco lectin Nictaba in complex with triacetylchitotriose
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Nictaba, ...
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2022-07-07
Release date:2023-01-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Tobacco lectin Nictaba in complex with triacetylchitotriose (CASP target)
To Be Published
6SFF
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BU of 6sff by Molmil
mouse Interleukin-12 subunit beta - p80 homodimer in space group I41
Descriptor: CHLORIDE ION, Interleukin-12 subunit beta, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Bloch, Y, Savvides, S.N.
Deposit date:2019-08-01
Release date:2020-08-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Homogeneously N-glycosylated proteins derived from the GlycoDelete HEK293 cell line enable diffraction-quality crystallogenesis.
Acta Crystallogr D Struct Biol, 76, 2020

 

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