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1KFD
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BU of 1kfd by Molmil
CRYSTAL STRUCTURES OF THE KLENOW FRAGMENT OF DNA POLYMERASE I COMPLEXED WITH DEOXYNUCLEOSIDE TRIPHOSPHATE AND PYROPHOSPHATE
Descriptor: CYTIDINE-5'-TRIPHOSPHATE, DNA POLYMERASE I KLENOW FRAGMENT
Authors:Beese, L.S, Friedman, J.M, Steitz, T.A.
Deposit date:1993-09-23
Release date:1994-06-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Crystal structures of the Klenow fragment of DNA polymerase I complexed with deoxynucleoside triphosphate and pyrophosphate.
Biochemistry, 32, 1993
1KLN
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BU of 1kln by Molmil
DNA POLYMERASE I KLENOW FRAGMENT (E.C.2.7.7.7) MUTANT/DNA COMPLEX
Descriptor: DNA (5'-D(*GP*CP*CP*GP*CP*GP*AP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*TP*CP*GP*CP*GP*GP*CP*GP*GP*C)-3'), PROTEIN (DNA POLYMERASE I KLENOW FRAGMENT (E.C.2.7.7.7)), ...
Authors:Beese, L.S, Derbyshire, V, Steitz, T.A.
Deposit date:1994-05-24
Release date:1994-11-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of DNA polymerase I Klenow fragment bound to duplex DNA.
Science, 260, 1993
1FT2
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BU of 1ft2 by Molmil
CO-CRYSTAL STRUCTURE OF PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A FARNESYL DIPHOSPHATE SUBSTRATE
Descriptor: FARNESYL DIPHOSPHATE, PROTEIN FARNESYLTRANSFERASE, ZINC ION
Authors:Beese, L.S, Casey, P.J, Long, S.B.
Deposit date:1998-06-02
Release date:1998-11-04
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate.
Biochemistry, 37, 1998
1FT1
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BU of 1ft1 by Molmil
CRYSTAL STRUCTURE OF PROTEIN FARNESYLTRANSFERASE AT 2.25 ANGSTROMS RESOLUTION
Descriptor: PROTEIN FARNESYLTRANSFERASE, ZINC ION
Authors:Beese, L.S, Park, H.-W.
Deposit date:1997-03-17
Release date:1998-03-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution.
Science, 275, 1997
3BDP
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BU of 3bdp by Molmil
DNA POLYMERASE I/DNA COMPLEX
Descriptor: DNA (5'-D(*AP*GP*CP*AP*TP*CP*AP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*AP*TP*GP*CP*2DT)-3'), PROTEIN (DNA POLYMERASE I), ...
Authors:Kiefer, J.R, Mao, C, Beese, L.S.
Deposit date:1997-11-17
Release date:1999-01-13
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal.
Nature, 391, 1998
1NJW
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BU of 1njw by Molmil
GUANINE-THYMINE MISMATCH AT THE POLYMERASE ACTIVE SITE
Descriptor: DNA POLYMERASE I, DNA PRIMER STRAND, DNA TEMPLATE STRAND, ...
Authors:Johnson, S.J, Beese, L.S.
Deposit date:2003-01-02
Release date:2004-03-30
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of mismatch replication errors observed in a DNA polymerase.
Cell(Cambridge,Mass.), 116, 2004
1NK5
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BU of 1nk5 by Molmil
ADENINE-ADENINE MISMATCH AT THE POLYMERASE ACTIVE SITE
Descriptor: DNA POLYMERASE I, DNA PRIMER STRAND, DNA TEMPLATE STRAND, ...
Authors:Johnson, S.J, Beese, L.S.
Deposit date:2003-01-02
Release date:2004-03-30
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of mismatch replication errors observed in a DNA polymerase.
Cell(Cambridge,Mass.), 116, 2004
1NK0
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BU of 1nk0 by Molmil
ADENINE-GUANINE MISMATCH AT THE POLYMERASE ACTIVE SITE
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA POLYMERASE I, DNA PRIMER STRAND, ...
Authors:Johnson, S.J, Beese, L.S.
Deposit date:2003-01-02
Release date:2004-03-30
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of mismatch replication errors observed in a DNA polymerase.
Cell(Cambridge,Mass.), 116, 2004
1NK7
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BU of 1nk7 by Molmil
GUANINE-ADENINE MISMATCH AT THE POLYMERASE ACTIVE SITE
Descriptor: DNA POLYMERASE I, DNA PRIMER STRAND, DNA TEMPLATE STRAND, ...
Authors:Johnson, S.J, Beese, L.S.
Deposit date:2003-01-02
Release date:2004-03-30
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of mismatch replication errors observed in a DNA polymerase.
Cell(Cambridge,Mass.), 116, 2004
1NKE
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BU of 1nke by Molmil
A BACILLUS DNA POLYMERASE I PRODUCT COMPLEX BOUND TO A CYTOSINE-THYMINE MISMATCH AFTER A SINGLE ROUND OF PRIMER EXTENSION, FOLLOWING INCORPORATION OF DCTP.
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA POLYMERASE I, DNA PRIMER STRAND, ...
Authors:Johnson, S.J, Beese, L.S.
Deposit date:2003-01-02
Release date:2004-03-30
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of mismatch replication errors observed in a DNA polymerase.
Cell(Cambridge,Mass.), 116, 2004
1D8E
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BU of 1d8e by Molmil
Zinc-depleted FTase complexed with K-RAS4B peptide substrate and FPP analog.
Descriptor: ACETATE ION, FARNESYLTRANSFERASE (ALPHA SUBUNIT), FARNESYLTRANSFERASE (BETA SUBUNIT), ...
Authors:Long, S.B, Casey, P.J, Beese, L.S.
Deposit date:1999-10-22
Release date:2000-03-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.
Structure Fold.Des., 8, 2000
1D8D
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BU of 1d8d by Molmil
CO-CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A K-RAS4B PEPTIDE SUBSTRATE AND FPP ANALOG AT 2.0A RESOLUTION
Descriptor: ACETATE ION, K-RAS4B PEPTIDE SUBSTRATE, ZINC ION, ...
Authors:Long, S.B, Casey, P.J, Beese, L.S.
Deposit date:1999-10-22
Release date:2000-02-09
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.
Structure Fold.Des., 8, 2000
4BDP
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BU of 4bdp by Molmil
CRYSTAL STRUCTURE OF BACILLUS DNA POLYMERASE I FRAGMENT COMPLEXED TO 11 BASE PAIRS OF DUPLEX DNA AFTER ADDITION OF TWO DATP RESIDUES
Descriptor: DNA (5'-D(*GP*CP*AP*TP*CP*AP*TP*GP*CP*AP*A)-3'), DNA (5'-D(*TP*AP*TP*TP*GP*CP*AP*TP*GP*AP*TP*GP*C)-3'), MAGNESIUM ION, ...
Authors:Kiefer, J.R, Mao, C, Beese, L.S.
Deposit date:1997-11-17
Release date:1999-01-13
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal.
Nature, 391, 1998
8T70
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BU of 8t70 by Molmil
Cryptococcus neoformans protein farnesyltransferase in complex with FPTII and TKCMIIM peptide
Descriptor: (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 1,2-ETHANEDIOL, MET-ILE-ILE-MET, ...
Authors:Wang, Y, Beese, L.S.
Deposit date:2023-06-19
Release date:2023-08-09
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.892 Å)
Cite:Cryptococcus neoformans protein farnesyltransferase in complex with FPTII and TKCMIIM peptide
To Be Published
8E9E
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BU of 8e9e by Molmil
Rat protein farnesyltransferase in complex with FPP and inhibitor 2f
Descriptor: (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Wang, Y, Shi, Y, Beese, L.S.
Deposit date:2022-08-26
Release date:2022-10-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.844 Å)
Cite:Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase.
J.Med.Chem., 65, 2022
1XC9
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BU of 1xc9 by Molmil
Structure of a high-fidelity polymerase bound to a benzo[a]pyrene adduct that blocks replication
Descriptor: 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE, DNA polymerase I, DNA primer strand, ...
Authors:Hsu, G.W, Huang, X, Luneva, N.P, Geacintov, N.E, Beese, L.S.
Deposit date:2004-09-01
Release date:2004-12-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a High Fidelity DNA Polymerase Bound to a Benzo[a]pyrene Adduct That Blocks Replication
J.Biol.Chem., 280, 2005
8TG1
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BU of 8tg1 by Molmil
Caldicellulosiruptor saccharolyticus periplasmic urea-binding protein
Descriptor: BROMIDE ION, Extracellular ligand-binding receptor, UREA
Authors:Allert, M.J, Kumar, S, Wang, Y, Beese, L.S, Hellinga, H.W.
Deposit date:2023-07-12
Release date:2024-06-19
Method:X-RAY DIFFRACTION (2.097 Å)
Cite:Structure-based functional analysis reveals multiple roles and widespread use of urea-binding proteins in nitrogen metabolism
To Be Published
1XWL
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BU of 1xwl by Molmil
BACILLUS STEAROTHERMOPHILUS (NEWLY IDENTIFIED STRAIN AS YET UNNAMED) DNA POLYMERASE FRAGMENT
Descriptor: DNA POLYMERASE I, SULFATE ION
Authors:Kiefer, J.R, Mao, C, Beese, L.S.
Deposit date:1998-07-22
Release date:1999-01-13
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 A resolution.
Structure, 5, 1997
2BDP
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BU of 2bdp by Molmil
CRYSTAL STRUCTURE OF BACILLUS DNA POLYMERASE I FRAGMENT COMPLEXED TO 9 BASE PAIRS OF DUPLEX DNA
Descriptor: DNA (5'-D(*GP*CP*AP*TP*GP*AP*TP*GP*C)-3'), DNA (5'-D(P*AP*GP*CP*AP*TP*CP*AP*TP*GP*C)-3'), MAGNESIUM ION, ...
Authors:Kiefer, J.R, Mao, C, Beese, L.S.
Deposit date:1997-11-17
Release date:1999-01-13
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal.
Nature, 391, 1998
1UA0
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BU of 1ua0 by Molmil
Aminofluorene DNA adduct at the pre-insertion site of a DNA polymerase
Descriptor: 2-AMINOFLUORENE, DNA polymerase I, DNA primer strand, ...
Authors:Hsu, G.W, Kiefer, J.R, Becherel, O.J, Fuchs, R.P.P, Beese, L.S.
Deposit date:2004-08-11
Release date:2004-09-28
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Observing translesion synthesis of an aromatic amine DNA adduct by a high-fidelity DNA polymerase
J.Biol.Chem., 279, 2004
1U4B
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BU of 1u4b by Molmil
Extension of an adenine-8oxoguanine mismatch
Descriptor: DNA polymerase I, DNA primer strand, DNA template strand with 8-oxoguanine, ...
Authors:Hsu, G.W, Ober, M, Carell, T, Beese, L.S.
Deposit date:2004-07-23
Release date:2004-09-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase.
Nature, 431, 2004
1UA1
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BU of 1ua1 by Molmil
Structure of aminofluorene adduct paired opposite cytosine at the polymerase active site.
Descriptor: 2-AMINOFLUORENE, DNA polymerase I, DNA primer strand, ...
Authors:Hsu, G.W, Kiefer, J.R, Becherel, O.J, Fuchs, R.P.P, Beese, L.S.
Deposit date:2004-08-11
Release date:2004-09-28
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Observing translesion synthesis of an aromatic amine DNA adduct by a high-fidelity DNA polymerase
J.Biol.Chem., 279, 2004
1U47
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BU of 1u47 by Molmil
cytosine-8-Oxoguanine base pair at the polymerase active site
Descriptor: DNA polymerase I, DNA primer strand, DNA template strand with 8-oxoguanine, ...
Authors:Hsu, G.W, Ober, M, Carell, T, Beese, L.S.
Deposit date:2004-07-23
Release date:2004-09-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase.
Nature, 431, 2004
1U49
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BU of 1u49 by Molmil
Adenine-8oxoguanine mismatch at the polymerase active site
Descriptor: DNA polymerase I, DNA primer strand, DNA template strand with 8-oxoguanine, ...
Authors:Hsu, G.W, Ober, M, Carell, T, Beese, L.S.
Deposit date:2004-07-23
Release date:2004-09-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase.
Nature, 431, 2004
1U48
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BU of 1u48 by Molmil
Extension of a cytosine-8-oxoguanine base pair
Descriptor: DNA polymerase I, DNA primer strand, DNA template strand with 8-oxoguanine, ...
Authors:Hsu, G.W, Ober, M, Carell, T, Beese, L.S.
Deposit date:2004-07-23
Release date:2004-09-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase.
Nature, 431, 2004

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