Author results

2CAR
  • Download 2car
  • View 2car
Molmil generated image of 2car
CRYSTAL STRUCTURE OF HUMAN INOSINE TRIPHOSPHATASE
Descriptor:INOSINE TRIPHOSPHATE PYROPHOSPHATASE
Authors:Stenmark, P., Kursula, P., Arrowsmith, C., Berglund, H., Edwards, A., Ehn, M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Hogbom, M., Holmberg Schiavone, L., Kotenyova, T., Nilsson-Ehle, P., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Schuler, H., Sundstrom, M., Thorsell, A.G., van den Berg, S., Weigelt, J., Nordlund, P.
Deposit date:2005-12-22
Release date:2006-01-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Crystal Structure of Human Inosine Triphosphatase. Substrate Binding and Implication of the Inosine Triphosphatase Deficiency Mutation P32T.
J.Biol.Chem., 282, 2007
2FE5
  • Download 2fe5
  • View 2fe5
Molmil generated image of 2fe5
THE CRYSTAL STRUCTURE OF THE SECOND PDZ DOMAIN OF HUMAN DLG3
Descriptor:Presynaptic protein SAP102, SULFATE ION, GLYCEROL
Authors:Ugochukwu, E., Phillips, C., Schoch, G., Berridge, G., Salah, E., Colebrook, S., Smee, C., Savitsky, P., Bray, J., Elkins, J., Doyle, D., Bunkoczi, G., Debreczeni, J., Turnbull, A., Gorrec, F., von Delft, F., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Structural Genomics Consortium (SGC)
Deposit date:2005-12-15
Release date:2005-12-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:The Crystal Structure of the Second PDZ Domain of Human DLG3
To be Published
2GZV
  • Download 2gzv
  • View 2gzv
Molmil generated image of 2gzv
THE CYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN PICK1
Descriptor:PRKCA-binding protein
Authors:Debreczeni, J.E., Elkins, J.M., Yang, X., Berridge, G., Bray, J., Colebrook, S., Smee, C., Savitsky, P., Gileadi, O., Turnbull, A., von Delft, F., Doyle, D.A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Structural Genomics Consortium (SGC)
Deposit date:2006-05-12
Release date:2006-07-18
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
Protein Sci., 16, 2007
2O23
  • Download 2o23
  • View 2o23
Molmil generated image of 2o23
THE STRUCTURE OF WILD-TYPE HUMAN HADH2 (17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 10) BOUND TO NAD+ AT 1.2 A
Descriptor:HADH2 protein, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, GLYCEROL
Authors:Kavanagh, K.L., Shafqat, N., Scholer, K., Debreczeni, J., Zschocke, J., von Delft, F., Weigelt, J., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-11-29
Release date:2006-12-12
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:The structure of wild-type human HADH2 (17beta-hydroxysteroid dehydrogenase type 10) bound to NAD+ at 1.2 A
To be Published
2B69
  • Download 2b69
  • View 2b69
Molmil generated image of 2b69
CRYSTAL STRUCTURE OF HUMAN UDP-GLUCORONIC ACID DECARBOXYLASE
Descriptor:UDP-glucuronate decarboxylase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, URIDINE-5'-DIPHOSPHATE
Authors:Ugochukwu, E., Dubinina, E., Kavanagh, K., Sundstrom, M., Weigelt, J., Edwards, A., Arrowsmith, C., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2005-09-30
Release date:2005-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Crystal Structure of Human UDP-glucoronic acid decarboxylase
To be Published
2C60
  • Download 2c60
  • View 2c60
Molmil generated image of 2c60
CRYSTAL STRUCTURE OF HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3 ISOFORM 2 PHOX DOMAIN AT 1.25 A RESOLUTION
Descriptor:HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3 ISOFORM 2, CALCIUM ION, GLYCEROL
Authors:Debreczeni, J.E., Salah, E., Papagrigoriou, E., Burgess, N., von Delft, F., Gileadi, O., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Knapp, S.
Deposit date:2005-11-04
Release date:2005-11-29
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase Kinase 3 Isoform 2 Fox Domain at 1.25 A Resolution
To be Published
2FVV
  • Download 2fvv
  • View 2fvv
Molmil generated image of 2fvv
HUMAN DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 1
Descriptor:Diphosphoinositol polyphosphate phosphohydrolase 1, CHLORIDE ION, SULFATE ION, ...
Authors:Hallberg, B.M., Kursula, P., Ogg, D., Arrowsmith, C., Berglund, H., Edwards, A., Ehn, M., Flodin, S., Graslund, S., Hammarstrom, M., Hogbom, M., Holmberg-Schiavone, L., Kotenyova, T., Nilsson-Ehle, P., Nordlund, P., Nyman, T., Sagemark, J., Stenmark, P., Sundstrom, M., Thorsell, A.G., van den Berg, S., Weigelt, J., Persson, C., Structural Genomics Consortium (SGC)
Deposit date:2006-01-31
Release date:2006-03-11
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Crystal structure of human diphosphoinositol phosphatase 1
Proteins, 77, 2009
2IZR
  • Download 2izr
  • View 2izr
Molmil generated image of 2izr
STRUCTURE OF CASEIN KINASE GAMMA 3 IN COMPLEX WITH INHIBITOR
Descriptor:CASEIN KINASE I ISOFORM GAMMA-3, {(2Z)-4-AMINO-2-[(4-METHOXYPHENYL)IMINO]-2,3-DIHYDRO-1,3-THIAZOL-5-YL}(4-METHOXYPHENYL)METHANONE, MAGNESIUM ION, ...
Authors:Bunkoczi, G., Salah, E., Rellos, P., Das, S., Fedorov, O., Savitsky, P., Debreczeni, J.E., Gileadi, O., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., von Delft, F., Knapp, S.
Deposit date:2006-07-26
Release date:2006-08-01
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Inhibitor Binding by Casein Kinases
To be Published
2J6L
  • Download 2j6l
  • View 2j6l
Molmil generated image of 2j6l
STRUCTURE OF AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE
Descriptor:ALDEHYDE DEHYDROGENASE FAMILY 7 MEMBER A1, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, BROMIDE ION, ...
Authors:Bunkoczi, G., Guo, K., Debreczeni, J.E., Smee, C., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., von Delft, F., Oppermann, U.
Deposit date:2006-09-29
Release date:2006-10-12
Last modified:2015-05-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Aldehyde Dehydrogenase 7A1 (Aldh7A1) is a Novel Enzyme Involved in Cellular Defense Against Hyperosmotic Stress.
J.Biol.Chem., 285, 2010
2OXC
  • Download 2oxc
  • View 2oxc
Molmil generated image of 2oxc
HUMAN DEAD-BOX RNA HELICASE DDX20, DEAD DOMAIN IN COMPLEX WITH ADP
Descriptor:Probable ATP-dependent RNA helicase DDX20, ADENOSINE-5'-DIPHOSPHATE
Authors:Karlberg, T., Ogg, D., Arrowsmith, C.H., Berglund, H., Busam, R.D., Collins, R., Dahlgren, L.G., Edwards, A., Flodin, S., Flores, A., Graslund, S., Hallberg, B.M., Hammarstrom, M., Hogbom, M., Johansson, I., Kotenyova, T., Lehtio, L., Moche, M., Nordlund, P., Nyman, T., Persson, C., Sagemark, J., Stenmark, P., Sundstrom, M., Thorsell, A.G., Van Den Berg, S., Weigelt, J., Holmberg-Schiavone, L., Structural Genomics Consortium (SGC)
Deposit date:2007-02-20
Release date:2007-02-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Human DEAD-box RNA helicase DDX20
To be Published
2IWN
  • Download 2iwn
  • View 2iwn
Molmil generated image of 2iwn
3RD PDZ DOMAIN OF MULTIPLE PDZ DOMAIN PROTEIN MPDZ (CASP TARGET)
Descriptor:MULTIPLE PDZ DOMAIN PROTEIN
Authors:Elkins, J.M., Gileadi, C., Savitsky, P., Berridge, G., Smee, C.E.A., Pike, A.C.W., Papagrigoriou, E., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Doyle, D.A.
Deposit date:2006-07-03
Release date:2006-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure of Pick1 and Other Pdz Domains Obtained with the Help of Self-Binding C-Terminal Extension.
Protein Sci., 16, 2007
2NXB
  • Download 2nxb
  • View 2nxb
Molmil generated image of 2nxb
CRYSTAL STRUCTURE OF HUMAN BROMODOMAIN CONTAINING PROTEIN 3 (BRD3)
Descriptor:Bromodomain-containing protein 3, SODIUM ION, 1,2-ETHANEDIOL
Authors:Filippakopoulos, P., Bullock, A., Cooper, C., Keates, K., Berridge, G., Pike, A., Bunkoczi, G., Edwards, A., Arrowsmith, C., Sundstrom, M., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-11-17
Release date:2006-12-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3MAO
  • Download 3mao
  • View 3mao
Molmil generated image of 3mao
CRYSTAL STRUCTURE OF HUMAN METHIONINE-R-SULFOXIDE REDUCTASE B1 (MSRB1)
Descriptor:Methionine-R-sulfoxide reductase B1, FE (III) ION, SODIUM ION, ...
Authors:Chaikuad, A., Shafqat, N., Yue, W.W., Savitsky, P., Krojer, T., Ugochukwu, E., Muniz, J.R.C., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2010-03-24
Release date:2010-04-07
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Crystal Structure of Human Methionine-R-Sulfoxide Reductase B1 (MsrB1)
To be Published
6EIM
  • Download 6eim
  • View 6eim
Molmil generated image of 6eim
HUMAN STK10 BOUND TO GW683134A
Descriptor:Serine/threonine-protein kinase 10, 1,2-ETHANEDIOL, ~{N}-[5-[4-[[2-fluoranyl-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1~{H}-benzimidazol-2-yl]furan-2-carboxamide
Authors:Sorrell, F.J., Berger, B.-T., Salah, E., von Delft, F., Bountra, C., Arrowsmith, C., Edwards, A.M., Knapp, S., Elkins, J.M.
Deposit date:2017-09-19
Release date:2017-11-01
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Human STK10 bound to GW683134
To Be Published
2C0C
  • Download 2c0c
  • View 2c0c
Molmil generated image of 2c0c
STRUCTURE OF THE MGC45594 GENE PRODUCT
Descriptor:ZINC BINDING ALCOHOL DEHYDROGENASE, DOMAIN CONTAINING 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Bunkoczi, G., Shafqat, N., Guo, K., Smee, C., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Gileadi, O., von Delft, F., Oppermann, U.
Deposit date:2005-08-30
Release date:2005-09-12
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The Structure of Mgc45594 Gene Product
To be Published
2HE4
  • Download 2he4
  • View 2he4
Molmil generated image of 2he4
THE CRYSTAL STRUCTURE OF THE SECOND PDZ DOMAIN OF HUMAN NHERF-2 (SLC9A3R2) INTERACTING WITH A MODE 1 PDZ BINDING MOTIF
Descriptor:Na(+)/H(+) exchange regulatory cofactor NHE-RF2, 1,2-ETHANEDIOL
Authors:Papagrigoriou, E., Elkins, J.M., Berridge, G., Gileady, O., Colebrook, S., Gileadi, C., Salah, E., Savitsky, P., Pantic, N., Gorrec, F., Bunkoczi, G., Weigelt, J., Arrowsmith, C., Sundstrom, M., Edwards, A., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2006-06-21
Release date:2006-07-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
Protein Sci., 16, 2007
6GRO
  • Download 6gro
  • View 6gro
Molmil generated image of 6gro
HUMAN CSNK1G3 BOUND TO SB-223133
Descriptor:Casein kinase I isoform gamma-3, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Szklarz, M., Vollmar, M., von Delft, F., Bountra, C., Knapp, S., Edwards, A.M., Arrowsmith, C., Elkins, J.M.
Deposit date:2018-06-12
Release date:2018-06-20
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:CSNK1G3 bound to SB-223133
To Be Published
1ZD8
  • Download 1zd8
  • View 1zd8
Molmil generated image of 1zd8
STRUCTURE OF HUMAN ADENYLATE KINASE 3 LIKE 1
Descriptor:GTP:AMP phosphotransferase mitochondrial
Authors:Choe, J., Atanassova, A., Arrowsmith, C., Edwards, A., Sundstrom, M., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2005-04-14
Release date:2005-05-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Structure of human adenylate kinase 3 like 1
to be published
1INL
  • Download 1inl
  • View 1inl
Molmil generated image of 1inl
CRYSTAL STRUCTURE OF SPERMIDINE SYNTHASE FROM THERMOTOGA MARITIMA
Descriptor:Spermidine synthase
Authors:Korolev, S., Skarina, T., Ikeguchi, Y., Pegg, A.E., Joachimiak, A., Edwards, A., Savchenko, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2001-05-14
Release date:2001-11-21
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor.
Nat.Struct.Biol., 9, 2002
2HE2
  • Download 2he2
  • View 2he2
Molmil generated image of 2he2
CRYSTAL STRUCTURE OF THE 3RD PDZ DOMAIN OF HUMAN DISCS LARGE HOMOLOGUE 2, DLG2
Descriptor:Discs large homolog 2
Authors:Turnbull, A.P., Phillips, C., Berridge, G., Savitsky, P., Smee, C.E.A., Papagrigoriou, E., Debreczeni, J., Gorrec, F., Elkins, J.M., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2006-06-21
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
Protein Sci., 16, 2007
2IBN
  • Download 2ibn
  • View 2ibn
Molmil generated image of 2ibn
CRYSTAL STRUCTURE OF HUMAN MYO-INOSITOL OXYGENASE (MIOX)
Descriptor:Inositol oxygenase, FE (III) ION, SULFATE ION, ...
Authors:Hallberg, B.M., Busam, R.D., Arrowsmith, C., Berglund, H., Collins, R., Edwards, A., Ehn, M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hogbom, M., Holmberg-Schiavone, L., Johansson, I., Karlberg, T., Kotenyova, T., Nilsson-Ehle, P., Nordlund, P., Nyman, T., Ogg, D., Sagemark, J., Stenmark, P., Sundstrom, M., Uppenberg, J., Van Den Berg, S., Weigelt, J., Thorsell, A.G., Persson, C., Structural Genomics Consortium (SGC)
Deposit date:2006-09-11
Release date:2006-10-17
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural and Biophysical Characterization of Human myo-Inositol Oxygenase
J.Biol.Chem., 283, 2008
2IWR
  • Download 2iwr
  • View 2iwr
Molmil generated image of 2iwr
GTPASE LIKE DOMAIN OF CENTAURIN GAMMA 1 (HUMAN)
Descriptor:CENTAURIN GAMMA 1
Authors:Elkins, J.M., Soundararajan, M., Yang, X., Papagrigoriou, E., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2006-07-03
Release date:2006-07-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The Centaurin Gamma-1 Gtpase-Like Domain Functions as an Ntpase.
Biochem.J., 401, 2007
2JC9
  • Download 2jc9
  • View 2jc9
Molmil generated image of 2jc9
CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC 5'-NUCLEOTIDASE II IN COMPLEX WITH ADENOSINE
Descriptor:CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, MAGNESIUM ION, ...
Authors:Wallden, K., Stenmark, P., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Edwards, A., Ehn, M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg, S.L., Hogbom, M., Karlberg, T., Kotenyova, T., Magnusdottir, A., Nilsson-Ehle, P., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Sundstrom, M., Uppenberg, J., Thorsell, A.G., Van Den Berg, S., Loppnau, P., Weigelt, J., Welin, M., Nordlund, P.
Deposit date:2006-12-21
Release date:2007-01-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of Human Cytosolic 5'-Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition
J.Biol.Chem., 282, 2007
2JKU
  • Download 2jku
  • View 2jku
Molmil generated image of 2jku
CRYSTAL STRUCTURE OF THE N-TERMINAL REGION OF THE BIOTIN ACCEPTOR DOMAIN OF HUMAN PROPIONYL-COA CARBOXYLASE
Descriptor:PROPIONYL-COA CARBOXYLASE ALPHA CHAIN, MITOCHONDRIAL, TETRAETHYLENE GLYCOL
Authors:Healy, S., Yue, W.W., Kochan, G., Pilka, E.S., Murray, J.W., Roos, A.K., Filippakopoulos, P., von Delft, F., Arrowsmith, C., Wikstrom, M., Edwards, A., Bountra, C., Gravel, R.A., Oppermann, U.
Deposit date:2008-08-30
Release date:2008-09-09
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural impact of human and Escherichia coli biotin carboxyl carrier proteins on biotin attachment.
Biochemistry, 49, 2010
4UYB
  • Download 4uyb
  • View 4uyb
Molmil generated image of 4uyb
CRYSTAL STRUCTURE OF SEC14-LIKE PROTEIN 3
Descriptor:SEC14-LIKE PROTEIN 3, 1,2-ETHANEDIOL, UNKNOWN LIGAND
Authors:Kopec, J., Goubin, S., Krojer, T., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2014-08-29
Release date:2014-09-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of Sec14-Like Protein 3
To be Published