Author results

1BWP
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PROBING THE SUBSTRATE SPECIFICITY OF THE INTRACELLULAR BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE
Descriptor:PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE
Authors:Ho, Y.S., Sheffield, P.J., Masuyama, J., Arai, H., Li, J., Aoki, J., Inoue, K., Derewenda, U., Derewenda, Z.
Deposit date:1998-09-27
Release date:1999-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Probing the Substrate Specificity of the Intracellular Brain Platelet-Activating Factor Acetylhydrolase
Protein Eng., 12, 1999
1BWQ
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PROBING THE SUBSTRATE SPECIFICITY OF THE INTRACELLULAR BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE
Descriptor:PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE
Authors:Ho, Y.S., Sheffield, P.J., Masuyama, J., Arai, H., Li, J., Aoki, J., Inoue, K., Derewenda, U., Derewenda, Z.
Deposit date:1998-09-27
Release date:1999-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Probing the Substrate Specificity of the Intracellular Brain Platelet-Activating Factor Acetylhydrolase
Protein Eng., 12, 1999
1BWR
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PROBING THE SUBSTRATE SPECIFICITY OF THE INTRACELLULAR BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE
Descriptor:PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE
Authors:Ho, Y.S., Sheffield, P.J., Masuyama, J., Arai, H., Li, J., Aoki, J., Inoue, K., Derewenda, U., Derewenda, Z.
Deposit date:1998-09-27
Release date:1999-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Probing the Substrate Specificity of the Intracellular Brain Platelet-Activating Factor Acetylhydrolase
Protein Eng., 12, 1999
1ES9
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X-RAY CRYSTAL STRUCTURE OF R22K MUTANT OF THE MAMMALIAN BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASES (PAF-AH)
Descriptor:PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB GAMMA SUBUNIT
Authors:McMullen, T.W.P., Li, J., Sheffield, P.J., Aoki, J., Martin, T.W., Arai, H., Inoue, K., Derewenda, Z.S.
Deposit date:2000-04-07
Release date:2000-05-31
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The functional implications of the dimerization of the catalytic subunits of the mammalian brain platelet-activating factor acetylhydrolase (Ib).
Protein Eng., 13, 2000
3NKM
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CRYSTAL STRUCTURE OF MOUSE AUTOTAXIN
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Nishimasu, H., Ishitani, R., Mihara, E., Takagi, J., Aoki, J., Nureki, O.
Deposit date:2010-06-20
Release date:2011-01-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
Nat.Struct.Mol.Biol., 18, 2011
3NKN
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CRYSTAL STRUCTURE OF MOUSE AUTOTAXIN IN COMPLEX WITH 14:0-LPA
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Nishimasu, H., Ishitani, R., Mihara, E., Takagi, J., Aoki, J., Nureki, O.
Deposit date:2010-06-20
Release date:2011-01-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
Nat.Struct.Mol.Biol., 18, 2011
3NKO
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CRYSTAL STRUCTURE OF MOUSE AUTOTAXIN IN COMPLEX WITH 16:0-LPA
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Nishimasu, H., Ishitani, R., Mihara, E., Takagi, J., Aoki, J., Nureki, O.
Deposit date:2010-06-20
Release date:2011-01-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
Nat.Struct.Mol.Biol., 18, 2011
3NKP
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CRYSTAL STRUCTURE OF MOUSE AUTOTAXIN IN COMPLEX WITH 18:1-LPA
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Nishimasu, H., Ishitani, R., Mihara, E., Takagi, J., Aoki, J., Nureki, O.
Deposit date:2010-06-20
Release date:2011-01-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
Nat.Struct.Mol.Biol., 18, 2011
3NKQ
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CRYSTAL STRUCTURE OF MOUSE AUTOTAXIN IN COMPLEX WITH 18:3-LPA
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Nishimasu, H., Ishitani, R., Mihara, E., Takagi, J., Aoki, J., Nureki, O.
Deposit date:2010-06-20
Release date:2011-01-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
Nat.Struct.Mol.Biol., 18, 2011
3NKR
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CRYSTAL STRUCTURE OF MOUSE AUTOTAXIN IN COMPLEX WITH 22:6-LPA
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Nishimasu, H., Ishitani, R., Mihara, E., Takagi, J., Aoki, J., Nureki, O.
Deposit date:2010-06-20
Release date:2011-01-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.704 Å)
Cite:Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
Nat.Struct.Mol.Biol., 18, 2011
5EGE
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STRUCTURE OF ENPP6, A CHOLINE-SPECIFIC GLYCEROPHOSPHODIESTER-PHOSPHODIESTERASE
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 6, N-ACETYL-D-GLUCOSAMINE, BETA-L-FUCOSE, ...
Authors:Morita, J., Kano, K., Kato, K., Takita, H., Ishitani, R., Nishimasu, H., Nureki, O., Aoki, J.
Deposit date:2015-10-27
Release date:2016-03-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase
Sci Rep, 6, 2016
5EGH
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STRUCTURE OF ENPP6, A CHOLINE-SPECIFIC GLYCEROPHOSPHODIESTER-PHOSPHODIESTERASE IN COMPLEX WITH PHOSPHOCHOLINE
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 6, N-ACETYL-D-GLUCOSAMINE, BETA-L-FUCOSE, ...
Authors:Morita, J., Kano, K., Kato, K., Takita, H., Ishitani, R., Nishimasu, H., Nureki, O., Aoki, J.
Deposit date:2015-10-27
Release date:2016-03-09
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase
Sci Rep, 6, 2016
1WAB
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PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE
Descriptor:PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE, ACETATE ION
Authors:Ho, Y.S., Swenson, L., Derewenda, U., Serre, L., Wei, Y., Dauter, Z., Hattori, M., Aoki, J., Arai, H., Adachi, T., Inoue, K., Derewenda, Z.S.
Deposit date:1996-10-30
Release date:1997-11-12
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer.
Nature, 385, 1997
6A93
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CRYSTAL STRUCTURE OF 5-HT2AR IN COMPLEX WITH RISPERIDONE
Descriptor:5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, 3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one, CHOLESTEROL, ...
Authors:Kimura, T.K., Asada, H., Inoue, A., Kadji, F.M.N., Im, D., Mori, C., Arakawa, T., Hirata, K., Nomura, Y., Nomura, N., Aoki, J., Iwata, S., Shimamura, T.
Deposit date:2018-07-11
Release date:2019-02-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepin
Nat.Struct.Mol.Biol., 26, 2019
6A94
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CRYSTAL STRUCTURE OF 5-HT2AR IN COMPLEX WITH ZOTEPINE
Descriptor:5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, 2-(3-chloranylbenzo[b][1]benzothiepin-5-yl)oxy-N,N-dimethyl-ethanamine, CHOLESTEROL, ...
Authors:Kimura, T.K., Asada, H., Inoue, A., Kadji, F.M.N., Im, D., Mori, C., Arakawa, T., Hirata, K., Nomura, Y., Nomura, N., Aoki, J., Iwata, S., Shimamura, T.
Deposit date:2018-07-11
Release date:2019-02-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepin
Nat.Struct.Mol.Biol., 26, 2019
6IGK
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CRYSTAL STRUCTURE OF HUMAN ETB RECEPTOR IN COMPLEX WITH ENDOTHELIN-3
Descriptor:Endothelin receptor type B,Endolysin,Endothelin receptor type B, Endothelin-3, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Shihoya, W., Izume, T., Inoue, A., Yamashita, K., Kadji, F.M.N., Hirata, K., Aoki, J., Nishizawa, T., Nureki, O.
Deposit date:2018-09-25
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of human ETBreceptor provide mechanistic insight into receptor activation and partial activation.
Nat Commun, 9, 2018
6IGL
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CRYSTAL STRUCTURE OF HUMAN ETB RECEPTOR IN COMPLEX WITH IRL1620
Descriptor:Endothelin receptor type B,Endolysin,Endothelin receptor type B, IRL1620, CITRIC ACID, ...
Authors:Shihoya, W., Izume, T., Inoue, A., Yamashita, K., kadji, F.M.N., Hirata, K., Aoki, J., Nishizawa, T., Nureki, O.
Deposit date:2018-09-25
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of human ETBreceptor provide mechanistic insight into receptor activation and partial activation.
Nat Commun, 9, 2018
5HRT
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CRYSTAL STRUCTURE OF MOUSE AUTOTAXIN IN COMPLEX WITH A DNA APTAMER
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, modified DNA (34-MER), N-ACETYL-D-GLUCOSAMINE, ...
Authors:Kato, K., Nishimasu, H., Morita, J., Ishitani, R., Nureki, O.
Deposit date:2016-01-24
Release date:2016-04-06
Last modified:2016-05-25
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:Structural basis for specific inhibition of Autotaxin by a DNA aptamer
Nat.Struct.Mol.Biol., 23, 2016
4GTW
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CRYSTAL STRUCTURE OF MOUSE ENPP1 IN COMPLEX WITH AMP
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, Alkaline phosphodiesterase I, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Kato, K., Nishimasu, H., Ishitani, R., Nureki, O.
Deposit date:2012-08-29
Release date:2012-11-07
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GTX
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CRYSTAL STRUCTURE OF MOUSE ENPP1 IN COMPLEX WITH TMP
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, Alkaline phosphodiesterase I, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Kato, K., Nishimasu, H., Ishitani, R., Nureki, O.
Deposit date:2012-08-29
Release date:2012-11-07
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (3.201 Å)
Cite:Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GTY
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CRYSTAL STRUCTURE OF MOUSE ENPP1 IN COMPLEX WITH GMP
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, Alkaline phosphodiesterase I, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Kato, K., Nishimasu, H., Ishitani, R., Nureki, O.
Deposit date:2012-08-29
Release date:2012-11-07
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GTZ
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CRYSTAL STRUCTURE OF MOUSE ENPP1 IN COMPLEX WITH CMP
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, Alkaline phosphodiesterase I, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Kato, K., Nishimasu, H., Ishitani, R., Nureki, O.
Deposit date:2012-08-29
Release date:2012-11-07
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (3.191 Å)
Cite:Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.
Proc.Natl.Acad.Sci.USA, 109, 2012
1JFR
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CRYSTAL STRUCTURE OF THE STREPTOMYCES EXFOLIATUS LIPASE AT 1.9A RESOLUTION: A MODEL FOR A FAMILY OF PLATELET-ACTIVATING FACTOR ACETYLHYDROLASES
Descriptor:LIPASE
Authors:Wei, Y., Derewenda, Z.S.
Deposit date:1997-07-11
Release date:1998-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a microbial homologue of mammalian platelet-activating factor acetylhydrolases: Streptomyces exfoliatus lipase at 1.9 A resolution.
Structure, 6, 1998
3WAV
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CRYSTAL STRUCTURE OF AUTOTAXIN IN COMPLEX WITH COMPOUND 10
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Nishimasu, H., Ishitani, R., Nureki, O.
Deposit date:2013-05-09
Release date:2013-07-31
Last modified:2013-10-16
Method:X-RAY DIFFRACTION (1.797 Å)
Cite:Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe
Acs Chem.Biol., 8, 2013
3WAW
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CRYSTAL STRUCTURE OF AUTOTAXIN IN COMPLEX WITH 2BOA
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Nishimasu, H., Ishitani, R., Nureki, O.
Deposit date:2013-05-09
Release date:2013-07-31
Last modified:2013-10-16
Method:X-RAY DIFFRACTION (1.954 Å)
Cite:Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe
Acs Chem.Biol., 8, 2013
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