Author results

6O1T
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BOVINE SALIVARY PROTEIN FORM 30B WITH OLEIC ACID
Descriptor:Short palate, lung and nasal epithelium carcinoma-associated protein 2B, CALCIUM ION, ...
Authors:Zhang, H., Arcus, V.L.
Deposit date:2019-02-21
Release date:2019-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of BSP30B with oleic acid at 2.3 Angstroms resolution
To Be Published
6NPU
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C-ABL KINASE DOMAIN WITH THE ACTIVATOR(CMPD29), N-(1-(3,4-DICHLOROPHENYL)-4,5-DIHYDRO-1H-PYRAZOL-3-YL)ACETAMIDE
Descriptor:Tyrosine-protein kinase ABL1, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, ~{N}-[2-(3,4-dichlorophenyl)-3,4-dihydropyrazol-5-yl]ethanamide, ...
Authors:Campobasso, N.
Deposit date:2019-01-18
Release date:2019-03-13
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Identification and Optimization of Novel Small c-Abl Kinase Activators Using Fragment and HTS Methodologies.
J. Med. Chem., 62, 2019
6NPV
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C-ABL KINASE DOMAIN WITH THE ACTIVATOR(CMPD51), N-(1-(3,4-DICHLOROPHENYL)-4-(2-HYDROXYETHYL)-4,5-DIHYDRO-1H-PYRAZOL-3-YL)ISONICOTINAMIDE
Descriptor:Tyrosine-protein kinase ABL1, SULFATE ION, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, ...
Authors:campobasso, N.
Deposit date:2019-01-18
Release date:2019-03-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Identification and Optimization of Novel Small c-Abl Kinase Activators Using Fragment and HTS Methodologies.
J. Med. Chem., 62, 2019
6NPE
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C-ABL KINASE DOMAIN WITH THE ACTIVATOR(CMPD6), 2-CYANO-N-(4-(3,4-DICHLOROPHENYL)THIAZOL-2-YL)ACETAMIDE
Descriptor:Tyrosine-protein kinase ABL1, SULFATE ION, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, ...
Authors:campobasso, N.
Deposit date:2019-01-17
Release date:2019-03-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Identification and Optimization of Novel Small c-Abl Kinase Activators Using Fragment and HTS Methodologies.
J. Med. Chem., 62, 2019
6J71
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HUA21-SCFV IN COMPLEX WITH THE EXTRACELLULAR DOMAIN(ECD) OF HER2
Descriptor:Receptor tyrosine-protein kinase erbB-2, anti-HER2 humanized antibody HuA21, BETA-D-MANNOSE, ...
Authors:Wang, Z., Guo, G., Cheng, B., Zhu, Z., Niu, L., Zhang, H.
Deposit date:2019-01-16
Release date:2019-02-27
Method:X-RAY DIFFRACTION (2.918 Å)
Cite:Structural insight into a matured humanized monoclonal antibody HuA21 against HER2-overexpressing cancer cells
To Be Published
6J6F
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LIGAND BINDING DOMAIN 1 AND 2 OF TALAROMYCES MARNEFFEI MP1 PROTEIN
Descriptor:Envelope glycoprotein, NICKEL (II) ION
Authors:Lam, W.H., Zhang, H., Hao, Q.
Deposit date:2019-01-15
Release date:2019-03-06
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Talaromyces marneffeiMp1 protein, a novel virulence factor, carries two arachidonic acid-binding domains to suppress inflammatory responses in hosts.
Infect. Immun., 2019
6J20
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CRYSTAL STRUCTURE OF THE HUMAN NK1 SUBSTANCE P RECEPTOR
Descriptor:Substance-P receptor,Endolysin, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one
Authors:Chen, S., Lu, M., Zhang, H., Wu, B., Zhao, Q.
Deposit date:2018-12-30
Release date:2019-03-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.
Nat Commun, 10, 2019
6J21
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CRYSTAL STRUCTURE OF THE HUMAN NK1 SUBSTANCE P RECEPTOR
Descriptor:Substance-P receptor,Endolysin, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Authors:Chen, S., Lu, M., Zhang, H., Wu, B., Zhao, Q.
Deposit date:2018-12-30
Release date:2019-03-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.
Nat Commun, 10, 2019
6NFX
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MBTD1 MBT REPEATS
Descriptor:MBT domain-containing protein 1,Enhancer of polycomb homolog 1, UNKNOWN ATOM OR ION, SODIUM ION, ...
Authors:Zhang, H., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-12-21
Release date:2019-01-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:MBTD1 MBT repeats
To Be Published
6ITW
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CRYSTAL STRUCTURE OF ATU4351 FROM AGROBACTERIUM TUMEFACIENS
Descriptor:Type VI immunity protein Atu4351
Authors:Shi, L., Gao, Z., Zhang, H., Dong, Y.
Deposit date:2018-11-26
Release date:2019-03-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the type VI immunity protein Tdi1 (Atu4351) from Agrobacterium tumefaciens.
Acta Crystallogr F Struct Biol Commun, 75, 2019
6INB
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CRYSTAL STRUCTURE OF AN ACETOLACTATE DECARBOXYLASE FROM KLEBSIELLA PNEUMONIAE
Descriptor:Alpha-acetolactate decarboxylase, ZINC ION, CHLORIDE ION
Authors:Wu, W., Zhang, Q., Bartlam, M.
Deposit date:2018-10-24
Release date:2019-01-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural characterization of an acetolactate decarboxylase from Klebsiella pneumoniae
Biochem. Biophys. Res. Commun., 509, 2019
6INC
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CRYSTAL STRUCTURE OF AN ACETOLACTATE DECARBOXYLASE FROM KLEBSIELLA PNEUMONIAE
Descriptor:Alpha-acetolactate decarboxylase, ZINC ION, CHLORIDE ION, ...
Authors:Wu, W., Zhang, Q., Bartlam, M.
Deposit date:2018-10-24
Release date:2019-01-16
Method:X-RAY DIFFRACTION (1.604 Å)
Cite:Structural characterization of an acetolactate decarboxylase from Klebsiella pneumoniae
Biochem. Biophys. Res. Commun., 509, 2019
6IIU
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CRYSTAL STRUCTURE OF THE HUMAN THROMBOXANE A2 RECEPTOR BOUND TO RAMATROBAN
Descriptor:Soluble cytochrome b562,Thromboxane A2 receptor,Rubredoxin,Thromboxane A2 receptor, 3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid, ZINC ION, ...
Authors:Fan, H., Zhao, Q., Wu, B.
Deposit date:2018-10-07
Release date:2018-12-19
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for ligand recognition of the human thromboxane A2receptor.
Nat. Chem. Biol., 15, 2019
6IIV
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CRYSTAL STRUCTURE OF THE HUMAN THROMBOXANE A2 RECEPTOR BOUND TO DALTROBAN
Descriptor:Soluble cytochrome b562,Thromboxane A2 receptor,Rubredoxin,Thromboxane A2 receptor, 2-[4-[2-[(4-chlorophenyl)sulfonylamino]ethyl]phenyl]ethanoic acid, ZINC ION, ...
Authors:Fan, H., Zhao, Q., Wu, B.
Deposit date:2018-10-07
Release date:2018-12-19
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for ligand recognition of the human thromboxane A2receptor.
Nat. Chem. Biol., 15, 2019
6AKK
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CRYSTAL STRUCTURE OF THE SECOND COILED-COIL DOMAIN OF SIKE1
Descriptor:Suppressor of IKBKE 1, GLYCEROL
Authors:Zhou, L., Chen, M., Zhou, Z.C.
Deposit date:2018-09-02
Release date:2019-01-16
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling.
Cell Discov, 5, 2019
6AKL
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CRYSTAL STRUCTURE OF STRIATIN3 IN COMPLEX WITH SIKE1 COILED-COIL DOMAIN
Descriptor:Suppressor of IKBKE 1, Striatin-3
Authors:Zhou, L., Chen, M., Zhou, Z.C.
Deposit date:2018-09-02
Release date:2019-01-16
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling.
Cell Discov, 5, 2019
6AKM
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CRYSTAL STRUCTURE OF SLMAP-SIKE1 COMPLEX
Descriptor:Suppressor of IKBKE 1, Sarcolemmal membrane-associated protein, GLYCEROL
Authors:Ma, J., Chen, M., Zhou, Z.C.
Deposit date:2018-09-02
Release date:2019-01-16
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling.
Cell Discov, 5, 2019
6E31
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CRYSTAL STRUCTURE OF RIAM IN AN AUTOINHIBITED CONFIGURATION.
Descriptor:Rap1-interacting adapter molecule
Authors:Chang, Y.C., Su, W., Zhang, H., Huang, Q., Philips, M.R., Wu, J.
Deposit date:2018-07-12
Release date:2019-02-20
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular basis for autoinhibition of RIAM regulated by FAK in integrin activation.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6A8R
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CRYSTAL STRUCTURE OF DUX4 HD2 DOMAIN ASSOCIATED WITH ERG DNA BINDING SITE
Descriptor:Double homeobox protein 4, DNA (5'-D(P*TP*GP*AP*TP*GP*AP*GP*AP*TP*T)-3'), DNA (5'-D(P*AP*AP*TP*CP*TP*CP*AP*TP*CP*A)-3')
Authors:Dong, X., Zhang, H., Cheng, N., Meng, G.
Deposit date:2018-07-10
Release date:2018-10-24
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:DUX4HD2-DNAERGstructure reveals new insight into DUX4-Responsive-Element.
Leukemia, 33, 2019
6GK7
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CRYSTAL STRUCTURE OF ANTI-TAU ANTIBODY DMCBTAU-27.1, DOUBLE MUTANT (S31Y, T100I) OF CBTAU-27.1, IN COMPLEX WITH TAU PEPTIDE A8119B (RESIDUES 299-318)
Descriptor:HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-27.1(S31Y,T100I), HUMAN TAU PEPTIDE A8119 RESIDUES 299-318, CHLORIDE ION
Authors:Steinbacher, S., Mrosek, M., Juraszek, J.
Deposit date:2018-05-18
Release date:2018-06-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6, 2018
6GK8
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CRYSTAL STRUCTURE OF ANTI-TAU ANTIBODY DMCBTAU-28.1, DOUBLE MUTANT (S32R, E35K) OF CBTAU-28.1, IN COMPLEX WITH TAU PEPTIDE A7731 (RESIDUES 52-71)
Descriptor:HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-28.1(S32R;E35K), TAU PEPTIDE A7731 (RESIDUES 52-71), CHLORIDE ION
Authors:Steinbacher, S., Mrosek, M., Juraszek, J.
Deposit date:2018-05-18
Release date:2018-06-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6, 2018
5ZWX
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CRYSTAL STRUCTURE OF RAPHANUS SATIVUS AGDP1 AGD12 IN COMPLEX WITH AN H3K9ME2 PEPTIDE
Descriptor:DUF724 domain-containing protein 6-like, H3(1-15)K9me2 peptide
Authors:Du, X., Du, J.
Deposit date:2018-05-17
Release date:2018-11-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin
Nat Commun, 9, 2018
5ZWZ
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA AGDP1 AGD34
Descriptor:Agenet domain-containing protein
Authors:Du, X., Du, J.
Deposit date:2018-05-17
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin
Nat Commun, 9, 2018
5ZV3
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CRYSTAL STRUCTURE OF HUMAN ANTI-TAU ANTIBODY CBTAU-28.1 IN COMPLEX WITH ITS TAU PEPTIDE
Descriptor:Peptide from Microtubule-associated protein tau, Heavy chain of antibody CBTAU28.1, Light chain (kappa) of antibody CBTAU28.1
Authors:Zhang, H., Wilson, I.A.
Deposit date:2018-05-09
Release date:2018-06-20
Method:X-RAY DIFFRACTION (2.093 Å)
Cite:A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6, 2018
6DCV
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CRYSTAL STRUCTURE OF HUMAN ANTI-TAU ANTIBODY CBTAU-27.1
Descriptor:Light chain of CBTAU27.1 Fab, heavy chain of CBTAU-27.1 Fab, GLYCEROL
Authors:Zhu, X., Zhang, H., Wilson, I.A.
Deposit date:2018-05-08
Release date:2018-06-06
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6, 2018