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1H3I
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CRYSTAL STRUCTURE OF THE HISTONE METHYLTRANSFERASE SET7/9
Descriptor:HISTONE H3 LYSINE 4 SPECIFIC METHYLTRANSFERASE, MAGNESIUM ION
Authors:Wilson, J.R., Jing, C., Walker, P.A., Martin, S.R., Howell, S.A., Blackburn, G.M., Gamblin, S.J., Xiao, B.
Deposit date:2002-09-04
Release date:2002-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure and Functional Analysis of the Histone Methyltransferase Set7/9
Cell(Cambridge,Mass.), 111, 2002
1O9S
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CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF THE HUMAN HISTONE METHYLTRANSFERASE SET7/9
Descriptor:HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-4 SPECIFIC, GENE FRAGMENT FOR HISTONE H3, ...
Authors:Xiao, B., Jing, C., Wilson, J.R., Walker, P.A., Vasisht, N., Kelly, G., Howell, S., Taylor, I.A., Blackburn, G.M., Gamblin, S.J.
Deposit date:2002-12-18
Release date:2003-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure and Catalytic Mechanism of the Human Histone Methyltransferase Set7/9
Nature, 421, 2003
1XQH
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CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF THE METHYLTRANSFERASE SET9 (ALSO KNOWN AS SET7/9) WITH A P53 PEPTIDE AND SAH
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-4 specific, 9-mer peptide from tumor protein p53, ...
Authors:Chuikov, S., Kurash, J.K., Wilson, J.R., Xiao, B., Justin, N., Ivanov, G.S., McKinney, K., Tempst, P., Prives, C., Gamblin, S.J., Barlev, N.A., Reinberg, D.
Deposit date:2004-10-12
Release date:2004-11-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Regulation of p53 activity through lysine methylation
Nature, 432, 2004
2BQZ
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CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF THE HUMAN HISTONE METHYLTRANSFERASE PR-SET7 (ALSO KNOWN AS SET8)
Descriptor:SET8 PROTEIN, HISTONE H4, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Xiao, B., Jing, C., Kelly, G., Walker, P.A., Muskett, F.W., Frenkiel, T.A., Martin, S.R., Sarma, K., Reinberg, D., Gamblin, S.J., Wilson, J.R.
Deposit date:2005-04-28
Release date:2005-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Specificity and Mechanism of the Histone Methyltransferase Pr-Set7
Genes Dev., 19, 2005
2W5Y
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BINARY COMPLEX OF THE MIXED LINEAGE LEUKAEMIA (MLL1) SET DOMAIN WITH THE COFACTOR PRODUCT S-ADENOSYLHOMOCYSTEINE.
Descriptor:HISTONE-LYSINE N-METHYLTRANSFERASE HRX, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Southall, S.M., Wong, P.S., Odho, Z., Roe, S.M., WIlson, J.R.
Deposit date:2008-12-15
Release date:2009-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for the Requirement of Additional Factors for Mll1 Set Domain Activity and Recognition of Epigenetic Marks.
Mol.Cell, 33, 2009
2W5Z
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TERNARY COMPLEX OF THE MIXED LINEAGE LEUKAEMIA (MLL1) SET DOMAIN WITH THE COFACTOR PRODUCT S-ADENOSYLHOMOCYSTEINE AND HISTONE PEPTIDE.
Descriptor:HISTONE-LYSINE N-METHYLTRANSFERASE HRX, HISTONE PEPTIDE, ZINC ION, ...
Authors:Southall, S.M., Wong, P.S., Odho, Z., Roe, S.M., Wilson, J.R.
Deposit date:2008-12-15
Release date:2009-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for the Requirement of Additional Factors for Mll1 Set Domain Activity and Recognition of Epigenetic Marks.
Mol.Cell, 33, 2009
2XL2
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WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE RECRUITED TO NOVEL SITE
Descriptor:WD REPEAT-CONTAINING PROTEIN 5, RETINOBLASTOMA-BINDING PROTEIN 5, GLYCEROL
Authors:Odho, Z., Southall, S.M., Wilson, J.R.
Deposit date:2010-07-19
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Characterisation of a Novel Wdr5 Binding Site that Recruits Rbbp5 Through a Conserved Motif and Enhances Methylation of H3K4 by Mll1.
J.Biol.Chem., 285, 2010
2XL3
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WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE AND HISTONE H3 PEPTIDE
Descriptor:WD REPEAT-CONTAINING PROTEIN 5, RETINOBLASTOMA-BINDING PROTEIN 5, HISTONE H3.1, ...
Authors:Odho, Z., Southall, S.M., Wilson, J.R.
Deposit date:2010-07-19
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Characterisation of a Novel Wdr5 Binding Site that Recruits Rbbp5 Through a Conserved Motif and Enhances Methylation of H3K4 by Mll1.
J.Biol.Chem., 285, 2010
4AU7
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THE STRUCTURE OF THE SUV4-20H2 TERNARY COMPLEX WITH HISTONE H4
Descriptor:HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H2, HISTONE H4 PEPTIDE, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Southall, S.M., Cronin, N.B., Wilson, J.R.
Deposit date:2012-05-14
Release date:2013-05-22
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:A Novel Route to Product Specificity in the Suv4-20 Family of Histone H4K20 Methyltransferases.
Nucleic Acids Res., 42, 2014
4BUP
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A NOVEL ROUTE TO PRODUCT SPECIFICITY IN THE SUV4-20 FAMILY OF HISTONE H4K20 METHYLTRANSFERASES
Descriptor:HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1, ZINC ION, S-ADENOSYLMETHIONINE, ...
Authors:Southall, S.M., Cronin, N.B., Wilson, J.R.
Deposit date:2013-06-21
Release date:2013-10-02
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2.166 Å)
Cite:A Novel Route to Product Specificity in the Suv4-20 Family of Histone H4K20 Methyltransferases.
Nucleic Acids Res., 42, 2014
4Z4P
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STRUCTURE OF THE MLL4 SET DOMAIN
Descriptor:Histone-lysine N-methyltransferase 2D, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Zhang, Z., Mittal, A., Reid, J., Reich, S., Gamblin, S.J., Wilson, J.R.
Deposit date:2015-04-02
Release date:2015-09-09
Last modified:2015-10-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Evolving Catalytic Properties of the MLL Family SET Domain.
Structure, 23, 2015
5HYN
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STRUCTURE OF HUMAN POLYCOMB REPRESSIVE COMPLEX 2 (PRC2) WITH ONCOGENIC HISTONE H3K27M PEPTIDE
Descriptor:Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ...
Authors:Zhang, Y., Justin, N., Wilson, J.R., Gamblin, S.J.
Deposit date:2016-02-01
Release date:2016-05-11
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
Nat Commun, 7, 2016
5OV3
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STRUCTURE OF THE RBBP5 BETA-PROPELLER DOMAIN
Descriptor:Retinoblastoma-binding protein 5, TRIETHYLENE GLYCOL, TETRAETHYLENE GLYCOL
Authors:Mittal, A., Zhang, Y., Gamblin, S.J., Wilson, J.R.
Deposit date:2017-08-27
Release date:2018-03-28
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The structure of the RbBP5 beta-propeller domain reveals a surface with potential nucleic acid binding sites.
Nucleic Acids Res., 46, 2018
5LS6
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STRUCTURE OF HUMAN POLYCOMB REPRESSIVE COMPLEX 2 (PRC2) WITH INHIBITOR
Descriptor:Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ...
Authors:Zhang, Y., Justin, N., Chen, S., Wilson, J., Gamblin, S.
Deposit date:2016-08-22
Release date:2017-02-22
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (3.47 Å)
Cite:Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas.
J. Med. Chem., 59, 2016
5M5G
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CRYSTAL STRUCTURE OF THE CHAETOMIUM THERMOPHILUM POLYCOMB REPRESSIVE COMPLEX 2 (PRC2)
Descriptor:putative polycomb protein EED, Putative uncharacterized protein, HISTONE H3 11-Mer peptide, ...
Authors:Zhang, Y., Justin, N., Wilson, J., Gamblin, S.
Deposit date:2016-10-21
Release date:2017-01-11
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".
Science, 354, 2016