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1H3I
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BU of 1h3i by Molmil
Crystal structure of the Histone Methyltransferase SET7/9
Descriptor: HISTONE H3 LYSINE 4 SPECIFIC METHYLTRANSFERASE, MAGNESIUM ION
Authors:Wilson, J.R, Jing, C, Walker, P.A, Martin, S.R, Howell, S.A, Blackburn, G.M, Gamblin, S.J, Xiao, B.
Deposit date:2002-09-04
Release date:2002-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure and Functional Analysis of the Histone Methyltransferase Set7/9
Cell(Cambridge,Mass.), 111, 2002
5OV3
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BU of 5ov3 by Molmil
Structure of the RbBP5 beta-propeller domain
Descriptor: Retinoblastoma-binding protein 5, TETRAETHYLENE GLYCOL, TRIETHYLENE GLYCOL
Authors:Mittal, A, Zhang, Y, Gamblin, S.J, Wilson, J.R.
Deposit date:2017-08-27
Release date:2018-03-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The structure of the RbBP5 beta-propeller domain reveals a surface with potential nucleic acid binding sites.
Nucleic Acids Res., 46, 2018
2XL2
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BU of 2xl2 by Molmil
WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE RECRUITED TO NOVEL SITE
Descriptor: GLYCEROL, RETINOBLASTOMA-BINDING PROTEIN 5, WD REPEAT-CONTAINING PROTEIN 5
Authors:Odho, Z, Southall, S.M, Wilson, J.R.
Deposit date:2010-07-19
Release date:2010-08-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Characterisation of a Novel Wdr5 Binding Site that Recruits Rbbp5 Through a Conserved Motif and Enhances Methylation of H3K4 by Mll1.
J.Biol.Chem., 285, 2010
2XL3
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WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE AND HISTONE H3 PEPTIDE
Descriptor: GLYCEROL, HISTONE H3.1, RETINOBLASTOMA-BINDING PROTEIN 5, ...
Authors:Odho, Z, Southall, S.M, Wilson, J.R.
Deposit date:2010-07-19
Release date:2010-08-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Characterisation of a Novel Wdr5 Binding Site that Recruits Rbbp5 Through a Conserved Motif and Enhances Methylation of H3K4 by Mll1.
J.Biol.Chem., 285, 2010
4AU7
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BU of 4au7 by Molmil
The structure of the Suv4-20h2 ternary complex with histone H4
Descriptor: 1,2-ETHANEDIOL, HISTONE H4 PEPTIDE, HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H2, ...
Authors:Southall, S.M, Cronin, N.B, Wilson, J.R.
Deposit date:2012-05-14
Release date:2013-05-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:A Novel Route to Product Specificity in the Suv4-20 Family of Histone H4K20 Methyltransferases.
Nucleic Acids Res., 42, 2014
4BUP
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BU of 4bup by Molmil
A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases
Descriptor: GLYCEROL, HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1, S-ADENOSYLMETHIONINE, ...
Authors:Southall, S.M, Cronin, N.B, Wilson, J.R.
Deposit date:2013-06-21
Release date:2013-10-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.166 Å)
Cite:A Novel Route to Product Specificity in the Suv4-20 Family of Histone H4K20 Methyltransferases.
Nucleic Acids Res., 42, 2014
4Z4P
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BU of 4z4p by Molmil
Structure of the MLL4 SET Domain
Descriptor: Histone-lysine N-methyltransferase 2D, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION
Authors:Zhang, Z, Mittal, A, Reid, J, Reich, S, Gamblin, S.J, Wilson, J.R.
Deposit date:2015-04-02
Release date:2015-09-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Evolving Catalytic Properties of the MLL Family SET Domain.
Structure, 23, 2015
5HYN
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BU of 5hyn by Molmil
Structure of Human Polycomb Repressive Complex 2 (PRC2) with oncogenic histone H3K27M peptide
Descriptor: H3K27M, Histone-lysine N-methyltransferase EZH2, JARID2 K116me3, ...
Authors:Zhang, Y, Justin, N, Wilson, J.R, Gamblin, S.J.
Deposit date:2016-02-01
Release date:2016-05-11
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
Nat Commun, 7, 2016
2W5Z
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BU of 2w5z by Molmil
Ternary Complex of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and histone peptide.
Descriptor: GLYCEROL, HISTONE PEPTIDE, HISTONE-LYSINE N-METHYLTRANSFERASE HRX, ...
Authors:Southall, S.M, Wong, P.S, Odho, Z, Roe, S.M, Wilson, J.R.
Deposit date:2008-12-15
Release date:2009-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for the Requirement of Additional Factors for Mll1 Set Domain Activity and Recognition of Epigenetic Marks.
Mol.Cell, 33, 2009
2W5Y
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BU of 2w5y by Molmil
Binary Complex of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine.
Descriptor: HISTONE-LYSINE N-METHYLTRANSFERASE HRX, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION
Authors:Southall, S.M, Wong, P.S, Odho, Z, Roe, S.M, WIlson, J.R.
Deposit date:2008-12-15
Release date:2009-02-10
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for the Requirement of Additional Factors for Mll1 Set Domain Activity and Recognition of Epigenetic Marks.
Mol.Cell, 33, 2009
2BQZ
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BU of 2bqz by Molmil
Crystal structure of a ternary complex of the human histone methyltransferase Pr-SET7 (also known as SET8)
Descriptor: HISTONE H4, S-ADENOSYL-L-HOMOCYSTEINE, SET8 PROTEIN
Authors:Xiao, B, Jing, C, Kelly, G, Walker, P.A, Muskett, F.W, Frenkiel, T.A, Martin, S.R, Sarma, K, Reinberg, D, Gamblin, S.J, Wilson, J.R.
Deposit date:2005-04-28
Release date:2005-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Specificity and Mechanism of the Histone Methyltransferase Pr-Set7
Genes Dev., 19, 2005
1XQH
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BU of 1xqh by Molmil
Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH
Descriptor: 9-mer peptide from tumor protein p53, Histone-lysine N-methyltransferase, H3 lysine-4 specific, ...
Authors:Chuikov, S, Kurash, J.K, Wilson, J.R, Xiao, B, Justin, N, Ivanov, G.S, McKinney, K, Tempst, P, Prives, C, Gamblin, S.J, Barlev, N.A, Reinberg, D.
Deposit date:2004-10-12
Release date:2004-11-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Regulation of p53 activity through lysine methylation
Nature, 432, 2004
1O9S
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BU of 1o9s by Molmil
Crystal structure of a ternary complex of the human histone methyltransferase SET7/9
Descriptor: GENE FRAGMENT FOR HISTONE H3, HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-4 SPECIFIC, ...
Authors:Xiao, B, Jing, C, Wilson, J.R, Walker, P.A, Vasisht, N, Kelly, G, Howell, S, Taylor, I.A, Blackburn, G.M, Gamblin, S.J.
Deposit date:2002-12-18
Release date:2003-02-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure and Catalytic Mechanism of the Human Histone Methyltransferase Set7/9
Nature, 421, 2003
5LS6
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BU of 5ls6 by Molmil
Structure of Human Polycomb Repressive Complex 2 (PRC2) with inhibitor
Descriptor: 1-[(1~{R})-1-[1-[2,2-bis(fluoranyl)propyl]piperidin-4-yl]ethyl]-~{N}-[(4-methoxy-6-methyl-2-oxidanylidene-3~{H}-pyridin-3-yl)methyl]-2-methyl-indole-3-carboxamide, Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2, Jarid2 K116me3, ...
Authors:Zhang, Y, Justin, N, Chen, S, Wilson, J, Gamblin, S.
Deposit date:2016-08-22
Release date:2017-02-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.47 Å)
Cite:Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas.
J. Med. Chem., 59, 2016
5M5G
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BU of 5m5g by Molmil
Crystal structure of the Chaetomium Thermophilum polycomb repressive complex 2 (PRC2)
Descriptor: Fragment from molecular 2 (region containing putative polycomb protein Suz12), HISTONE H3 11-Mer peptide, Putative uncharacterized protein, ...
Authors:Zhang, Y, Justin, N, Wilson, J, Gamblin, S.
Deposit date:2016-10-21
Release date:2017-01-11
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".
Science, 354, 2016
7ULN
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BU of 7uln by Molmil
Turnip yellows virus N-terminal readthrough domain
Descriptor: Minor capsid protein P3-RTD
Authors:Schiltz, C.J, Chappie, J.S.
Deposit date:2022-04-05
Release date:2022-11-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Polerovirus N-terminal readthrough domain structures reveal molecular strategies for mitigating virus transmission by aphids
Nat Commun, 13, 2022
7ULO
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BU of 7ulo by Molmil
Potato leafroll virus N-terminal readthrough domain
Descriptor: Minor capsid protein P3-RTD, SULFATE ION
Authors:Schiltz, C.J, Chappie, J.S.
Deposit date:2022-04-05
Release date:2022-11-02
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Polerovirus N-terminal readthrough domain structures reveal molecular strategies for mitigating virus transmission by aphids
Nat Commun, 13, 2022

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