Author results

5Y1Z
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CRYSTAL STRUCTURE OF ZMYND8 PHD-BROMO-PWWP TANDEM IN COMPLEX WITH DREBRIN ADF-H DOMAIN
Descriptor:Drebrin, Protein kinase C-binding protein 1, SULFATE ION, ...
Authors:Yao, N., Li, J., Liu, H., Wan, J., Liu, W., Zhang, M.
Deposit date:2017-07-22
Release date:2017-10-25
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.676 Å)
Cite:The Structure of the ZMYND8/Drebrin Complex Suggests a Cytoplasmic Sequestering Mechanism of ZMYND8 by Drebrin
Structure, 25, 2017
5ZRX
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CRYSTAL STRUCTURE OF EPHA2/SHIP2 COMPLEX
Descriptor:Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2,Ephrin type-A receptor 2
Authors:Wang, Y., Shang, Y., Li, J., Chen, W., Li, G., Wan, J., Liu, W., Zhang, M.
Deposit date:2018-04-25
Release date:2018-05-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions.
Elife, 7, 2018
5ZRY
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CRYSTAL STRUCTURE OF EPHA6/ODIN COMPLEX
Descriptor:Ankyrin repeat and SAM domain-containing protein 1A,Ephrin type-A receptor 6, SULFATE ION, GLYCEROL, ...
Authors:Wang, Y., Shang, Y., Li, J., Chen, W., Li, G., Wan, J., Liu, W., Zhang, M.
Deposit date:2018-04-25
Release date:2018-05-30
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions.
Elife, 7, 2018
5ZRZ
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CRYSTAL STRUCTURE OF EPHA5/SAMD5 COMPLEX
Descriptor:Ephrin type-A receptor 5, Sterile alpha motif domain-containing protein 5
Authors:Wang, Y., Shang, Y., Li, J., Chen, W., Li, G., Wan, J., Liu, W., Zhang, M.
Deposit date:2018-04-25
Release date:2018-05-30
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions.
Elife, 7, 2018
5TYT
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CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF RHOGEF BOUND TO CXCR2 C-TERMINAL PEPTIDE
Descriptor:Rho guanine nucleotide exchange factor 11, C-X-C chemokine receptor type 2 chimera
Authors:Spellmon, N., Holcomb, J., Niu, A., Choudhary, V., Sun, X., Brunzelle, J., Li, C., Yang, Z.
Deposit date:2016-11-21
Release date:2017-02-22
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:Structural basis of PDZ-mediated chemokine receptor CXCR2 scaffolding by guanine nucleotide exchange factor PDZ-RhoGEF.
Biochem. Biophys. Res. Commun., 485, 2017
3Q0Z
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CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE COMPLEX WITH (2E)-3-(4-{[(1-{[(13-CYCLOHEXYL-6-OXO-6,7-DIHYDRO-5H-INDOLO[1,2-D][1,4]BENZODIAZEPIN-10-YL)CARBONYL]AMINO}CYCLOPENTYL)CARBONYL]AMINO}PHENYL)PROP-2-ENOIC ACID
Descriptor:RNA-directed RNA polymerase, (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, SULFATE ION
Authors:Sheriff, S.
Deposit date:2010-12-16
Release date:2011-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.
Bioorg.Med.Chem.Lett., 21, 2011
4I0R
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CRYSTAL STRUCTURE OF SPLEEN TYROSINE KINASE COMPLEXED WITH 2-(3,4,5-TRIMETHOXY-PHENYL)-5H-PYRROLO[2,3-B]PYRAZINE-7-CARBOXYLIC ACID ISOPROPYLAMIDE
Descriptor:Tyrosine-protein kinase SYK, N-(propan-2-yl)-2-(3,4,5-trimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
Authors:Kuglstatter, A., Villasenor, A.G.
Deposit date:2012-11-19
Release date:2013-10-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors.
J.Med.Chem., 56, 2013
4I0S
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CRYSTAL STRUCTURE OF SPLEEN TYROSINE KINASE COMPLEXED WITH 2-(6-CHLORO-1-METHYL-1H-INDAZOL-3-YL)-5H-PYRROLO[2,3-B]PYRAZINE-7-CARBOXYLIC ACID ISOPROPYLAMIDE
Descriptor:Tyrosine-protein kinase SYK, 2-(6-chloro-1-methyl-1H-indazol-3-yl)-N-(propan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
Authors:Kuglstatter, A., Slade, M.
Deposit date:2012-11-19
Release date:2013-10-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors.
J.Med.Chem., 56, 2013
4I0T
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CRYSTAL STRUCTURE OF SPLEEN TYROSINE KINASE COMPLEXED WITH 2-(5,6,7,8-TETRAHYDRO-IMIDAZO[1,5-A]PYRIDIN-1-YL)-5H-PYRROLO[2,3-B]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYLAMIDE
Descriptor:Tyrosine-protein kinase SYK, N-tert-butyl-2-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
Authors:Kuglstatter, A., Slade, M.
Deposit date:2012-11-19
Release date:2013-10-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors.
J.Med.Chem., 56, 2013
4NLD
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CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE COMPLEX WITH BMS-791325 ALSO KNOWN AS (1AR,12BS)-8-CYCLOHEXYL-N-(DIMETHYLSULFAMOYL)-11-METHOXY-1A-{[(1R,5S)-3-METHYL-3,8-DIAZABICYCLO[3.2.1]OCT-8-YL]CARBONYL}-1,1A,2,12B-TETRAHYDROCYCLOPROPA[D]INDOLO[2,1-A][2]BENZAZEPINE-5-CARBOXAMIDE AND 2-(4-FLUOROPHENYL)-N-METHYL-6-[(METHYLSULFONYL)AMINO]-5-(PROPAN-2-YLOXY)-1-BENZOFURAN-3-CARBOXAMIDE
Descriptor:RNA-directed RNA polymerase, (1aR,12bS)-8-cyclohexyl-N-(dimethylsulfamoyl)-11-methoxy-1a-{[(1R,5S)-3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl]carbonyl}-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide, 2-(4-fluorophenyl)-N-methyl-6-[(methylsulfonyl)amino]-5-(propan-2-yloxy)-1-benzofuran-3-carboxamide, ...
Authors:Sheriff, S.
Deposit date:2013-11-14
Release date:2014-03-19
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase.
J.Med.Chem., 57, 2014
5ET0
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CRYSTAL STRUCTURE OF MYO3B-ARB2 IN COMPLEX WITH ESPIN1-AR
Descriptor:Espin, Myosin-IIIb
Authors:Liu, H., Li, J., Liu, W., Zhang, M.
Deposit date:2015-11-17
Release date:2016-02-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin
Elife, 5, 2016
5ET1
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CRYSTAL STRUCTURE OF MYO3B-ARB1 IN COMPLEX WITH ESPIN1-AR
Descriptor:Espin, Myosin-IIIb, GLYCEROL
Authors:Liu, H., Li, J., liu, W., Zhang, M.
Deposit date:2015-11-17
Release date:2016-02-03
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin
Elife, 5, 2016
5ZZ9
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CRYSTAL STRUCTURE OF HOMER2 EVH1/DREBRIN PPXXF COMPLEX
Descriptor:Homer protein homolog 2, Peptide from Drebrin
Authors:Li, Z., Liu, H., Li, J., Liu, W., Zhang, M.
Deposit date:2018-05-31
Release date:2018-12-19
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Homer Tetramer Promotes Actin Bundling Activity of Drebrin.
Structure, 27, 2019
6IRB
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C-TERMINAL COILED COIL DOMAIN OF DROSOPHILA PHOSPHOLIPASE C BETA NORPA, SELENOMETHIONINE
Descriptor:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
Authors:Ye, F., Li, J., Huang, Y., Liu, W., Zhang, M.
Deposit date:2018-11-12
Release date:2019-01-02
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (2.661 Å)
Cite:An unexpected INAD PDZ tandem-mediated plc beta binding inDrosophilaphoto receptors.
Elife, 7, 2018
6IRC
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C-TERMINAL DOMAIN OF DROSOPHILA PHOSPHOLIPASE B NORPA, METHYLATED
Descriptor:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
Authors:Ye, F., Li, J., Huang, Y., Liu, W., Zhang, M.
Deposit date:2018-11-12
Release date:2019-01-02
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (3.538 Å)
Cite:An unexpected INAD PDZ tandem-mediated plc beta binding inDrosophilaphoto receptors.
Elife, 7, 2018
6IRD
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COMPLEX STRUCTURE OF INADL PDZ89 AND PLCB4 C-TERMINAL CC-PBM
Descriptor:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase, InaD-like protein, GOLD ION
Authors:Ye, F., Li, J., Huang, Y., Liu, W., Zhang, M.
Deposit date:2018-11-12
Release date:2019-01-23
Method:X-RAY DIFFRACTION (2.813 Å)
Cite:An unexpected INAD PDZ tandem-mediated plc beta binding inDrosophilaphoto receptors.
Elife, 7, 2018
6IRE
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COMPLEX STRUCTURE OF INAD PDZ45 AND NORPA CC-PBM
Descriptor:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase, Inactivation-no-after-potential D protein
Authors:Ye, F., Li, J., Deng, X., Liu, W., Zhang, M.
Deposit date:2018-11-12
Release date:2019-01-23
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:An unexpected INAD PDZ tandem-mediated plc beta binding inDrosophilaphoto receptors.
Elife, 7, 2018
3QAE
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3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE OF STREPTOCOCCUS PNEUMONIAE
Descriptor:3-hydroxy-3-methylglutaryl-coenzyme a reductase, CITRIC ACID, GLYCEROL, ...
Authors:Zhang, L., Feng, L., Zhou, L., Gui, J., Wan, J.
Deposit date:2011-01-10
Release date:2011-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:3-hydroxy-3-methylglutaryl-coenzyme A reductase of Streptococcus pneumoniae
To be Published
3QAU
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3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:3-hydroxy-3-methylglutaryl-coenzyme a reductase, GLYCEROL, SULFATE ION, ...
Authors:Zhang, L., Feng, L., Zhou, L., Gui, J., Wan, J.
Deposit date:2011-01-11
Release date:2011-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:3-Hydroxy-3-MethylGlutaryl-Coenzyme A Reductase from Streptococcus pneumoniae
To be Published
5VB3
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X-RAY STRUCTURE OF NUCLEAR RECEPTOR ROR-GAMMAT LIGAND BINDING DOMAIN + SRC2 PEPTIDE
Descriptor:Nuclear receptor ROR-gamma, SRC2 chimera, SODIUM ION
Authors:Li, X.
Deposit date:2017-03-28
Release date:2017-06-07
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural studies unravel the active conformation of apo ROR gamma t nuclear receptor and a common inverse agonism of two diverse classes of ROR gamma t inhibitors.
J. Biol. Chem., 292, 2017
5VB5
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X-RAY CO-STRUCTURE OF NUCLEAR RECEPTOR ROR-GAMMAT LIGAND BINDING DOMAIN WITH AN INVERSE AGONIST AND SRC2 PEPTIDE
Descriptor:Nuclear receptor ROR-gamma, SRC2 chimera, SODIUM ION, ...
Authors:Li, X.
Deposit date:2017-03-28
Release date:2017-06-07
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.226 Å)
Cite:Structural studies unravel the active conformation of apo ROR gamma t nuclear receptor and a common inverse agonism of two diverse classes of ROR gamma t inhibitors.
J. Biol. Chem., 292, 2017
5VB6
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X-RAY CO-STRUCTURE OF NUCLEAR RECEPTOR ROR-GAMMAT LIGAND BINDING DOMAIN WITH AN INVERSE AGONIST AND SRC2 PEPTIDE
Descriptor:Nuclear receptor ROR-gamma, SRC2 chimera, SODIUM ION, ...
Authors:Li, X.
Deposit date:2017-03-28
Release date:2017-06-07
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.041 Å)
Cite:Structural studies unravel the active conformation of apo ROR gamma t nuclear receptor and a common inverse agonism of two diverse classes of ROR gamma t inhibitors.
J. Biol. Chem., 292, 2017
5VB7
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X-RAY CO-STRUCTURE OF NUCLEAR RECEPTOR ROR-GAMMAT LIGAND BINDING DOMAIN WITH AN AGONIST AND SRC2 PEPTIDE
Descriptor:Nuclear receptor ROR-gamma, SRC2 chimera, SODIUM ION, ...
Authors:Li, X.
Deposit date:2017-03-28
Release date:2017-06-07
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.335 Å)
Cite:Structural studies unravel the active conformation of apo ROR gamma t nuclear receptor and a common inverse agonism of two diverse classes of ROR gamma t inhibitors.
J. Biol. Chem., 292, 2017
3U15
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STRUCTURE OF HDMX WITH DIMER INDUCING INDOLYL HYDANTOIN RO-2443
Descriptor:Protein Mdm4, (5Z)-5-[(6-chloro-7-methyl-1H-indol-3-yl)methylidene]-3-(3,4-difluorobenzyl)imidazolidine-2,4-dione, SULFATE ION
Authors:Lukacs, C.M., Janson, C.A., Graves, B.J.
Deposit date:2011-09-29
Release date:2012-06-27
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization.
Proc.Natl.Acad.Sci.USA, 109, 2012
3VBG
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STRUCTURE OF HDM2 WITH DIMER INDUCING INDOLYL HYDANTOIN RO-2443
Descriptor:E3 ubiquitin-protein ligase Mdm2, (5Z)-5-[(6-chloro-7-methyl-1H-indol-3-yl)methylidene]-3-(3,4-difluorobenzyl)imidazolidine-2,4-dione
Authors:Lukacs, C.M., Janson, C.A., Graves, B.J.
Deposit date:2012-01-02
Release date:2012-06-27
Last modified:2012-08-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization.
Proc.Natl.Acad.Sci.USA, 109, 2012
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