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3KTU
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STRUCTURE OF HUMAN 8-OXOGUANINE GLYCOSYLASE 1 BOUND TO FLUORNINATED OXOG-CONTAINING DNA
Descriptor:N-glycosylase/DNA lyase, DNA (5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*CP*AP*(FDG)P*GP*TP*CP*TP*AP*C)-3'), ...
Authors:Verdine, G.L., Lee, S.M.
Deposit date:2009-11-26
Release date:2010-07-14
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural investigation of hOGG1 bound to a fluorinated oxoG analog
to be published
3IH7
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CRYSTAL STRUCTURE OF CATALYTICALLY ACTIVE HUMAN 8-OXOGUANINE GLYCOSYLASE DISTALLY CROSSLINKED TO GUANINE-CONTAINING DNA
Descriptor:N-glycosylase/DNA lyase, 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*G)-3', 5'-D(AP*TP*CP*TP*GP*GP*AP*CP*CP*TP*GP*CP*A)-3'
Authors:Verdine, G.L., Crenshaw, C.M., Oo, K.S., Kutchukian, P.S.
Deposit date:2009-07-29
Release date:2010-11-03
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A Catalytic Checkpoint in Base Excision by the Human 8-Oxoguanine DNA Glycosylase hOGG1
To be Published
3UBT
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CRYSTAL STRUCTURE OF C71S MUTANT OF DNA CYTOSINE-5 METHYLTRANSFERASE M.HAEIII BOUND TO DNA
Descriptor:Modification methylase HaeIII, 5'-D(*TP*GP*GP*CP*CP*A)-3', CHLORIDE ION, ...
Authors:Verdine, G.L., Didovyk, A.
Deposit date:2011-10-24
Release date:2012-10-03
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (2.502 Å)
Cite:Structural origins of DNA target selection and nucleobase extrusion by a DNA Cytosine methyltransferase.
J.Biol.Chem., 287, 2012
1ADN
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SOLUTION STRUCTURE OF THE DNA METHYLPHOSPHOTRIESTER REPAIR DOMAIN OF ESCHERICHIA COLI ADA
Descriptor:N-ADA 10, ZINC ION
Authors:Myers, L.C., Verdine, G.L., Wagner, G.
Deposit date:1993-09-30
Release date:1994-01-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the DNA methyl phosphotriester repair domain of Escherichia coli Ada.
Biochemistry, 32, 1993
1DCT
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DNA (CYTOSINE-5) METHYLASE FROM HAEIII COVALENTLY BOUND TO DNA
Descriptor:DNA (5'-D(*AP*CP*CP*AP*GP*CP*AP*GP*GP*(C49)P*CP*AP*CP*CP*AP*GP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*CP*TP*GP*GP*TP*GP*GP*(C5M)P*CP*TP*GP*CP*TP*GP*G)-3'), PROTEIN (MODIFICATION METHYLASE HAEIII), ...
Authors:Reinisch, K.M., Chen, L., Verdine, G.L., Lipscomb, W.N.
Deposit date:1995-05-17
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing.
Cell(Cambridge,Mass.), 82, 1995
1FN7
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COUPLING OF DAMAGE RECOGNITION AND CATALYSIS BY A HUMAN BASE-EXCISION DNA REPAIR PROTEIN
Descriptor:DNA (5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3'), DNA (5'-D(*GP*CP*GP*TP*CP*CP*AP*(3DR)P*GP*TP*CP*TP*AP*CP*C)-3'), 8-OXOGUANINE DNA GLYCOSYLASE 1, ...
Authors:Norman, D.P.G., Bruner, S.D., Verdine, G.L.
Deposit date:2000-08-21
Release date:2001-04-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Coupling of substrate recognition and catalysis by a human base-excision DNA repair protein.
J.Am.Chem.Soc., 123, 2001
1A3Q
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HUMAN NF-KAPPA-B P52 BOUND TO DNA
Descriptor:DNA (5'-D(*GP*GP*GP*GP*AP*AP*TP*CP*CP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*GP*AP*TP*TP*CP*CP*CP*C)-3'), PROTEIN (NUCLEAR FACTOR KAPPA-B P52)
Authors:Cramer, P., Larson, C.J., Verdine, G.L., Muller, C.W.
Deposit date:1998-01-23
Release date:1998-06-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the human NF-kappaB p52 homodimer-DNA complex at 2.1 A resolution.
EMBO J., 16, 1997
1A66
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SOLUTION NMR STRUCTURE OF THE CORE NFATC1/DNA COMPLEX, 18 STRUCTURES
Descriptor:DNA (5'-D(*CP*GP*AP*GP*GP*AP*AP*AP*AP*TP*TP*G)-3'), DNA (5'-D(*CP*AP*AP*TP*TP*TP*TP*CP*CP*TP*CP*G)-3'), CORE NFATC1
Authors:Zhou, P., Sun, L.J., Doetsch, V., Wagner, G., Verdine, G.L.
Deposit date:1998-03-06
Release date:1998-06-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the core NFATC1/DNA complex.
Cell(Cambridge,Mass.), 92, 1998
1BNK
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HUMAN 3-METHYLADENINE DNA GLYCOSYLASE COMPLEXED TO DNA
Descriptor:DNA (5'-D(*GP*AP*CP*AP*TP*GP*YRRP*TP*TP*GP*CP*CP*T)-3'), DNA (5'-D(*GP*GP*CP*AP*AP*TP*CP*AP*TP*GP*TP*CP*A)-3'), PROTEIN (3-METHYLADENINE DNA GLYCOSYLASE)
Authors:Lau, A.Y., Schaerer, O.D., Samson, L., Verdine, G.L., Ellenberger, T.
Deposit date:1998-07-29
Release date:1998-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision.
Cell(Cambridge,Mass.), 95, 1998
1CW9
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DNA DECAMER WITH AN ENGINEERED CROSSLINK IN THE MINOR GROOVE
Descriptor:5'-D(*CP*CP*AP*GP*(G47)P*CP*CP*TP*GP*G)-3', CALCIUM ION
Authors:van Aalten, D.M.F., Erlanson, D.A., Verdine, G.L., Joshua-Tor, L.
Deposit date:1999-08-26
Release date:1999-10-14
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:A structural snapshot of base-pair opening in DNA.
Proc.Natl.Acad.Sci.USA, 96, 1999
1EBM
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CRYSTAL STRUCTURE OF THE HUMAN 8-OXOGUANINE GLYCOSYLASE (HOGG1) BOUND TO A SUBSTRATE OLIGONUCLEOTIDE
Descriptor:DNA (5'-D(*GP*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3'), 8-OXOGUANINE DNA GLYCOSYLASE, ...
Authors:Bruner, S.D., Norman, D.P., Verdine, G.L.
Deposit date:2000-01-24
Release date:2000-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA.
Nature, 403, 2000
1EYF
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REFINED STRUCTURE OF THE DNA METHYL PHOSPHOTRIESTER REPAIR DOMAIN OF E. COLI ADA
Descriptor:ADA REGULATORY PROTEIN, ZINC ION
Authors:Lin, Y., Dotsch, V., Wintner, T., Peariso, K., Myers, L.C., Penner-Hahn, J.E., Verdine, G.L., Wagner, G.
Deposit date:2000-05-06
Release date:2003-09-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for the functional switch of the E. coli Ada protein
Biochemistry, 40, 2001
1HU0
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CRYSTAL STRUCTURE OF AN HOGG1-DNA BOROHYDRIDE TRAPPED INTERMEDIATE COMPLEX
Descriptor:5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*GP*CP*GP*TP*CP*CP*AP*(PED)P*GP*TP*CP*TP*AP*CP*C)-3', 8-OXOGUANINE DNA GLYCOSYLASE 1, ...
Authors:Fromme, J.C., Bruner, S.D., Yang, W., Karplus, M., Verdine, G.L.
Deposit date:2001-01-03
Release date:2003-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Product-Assisted Catalysis in base-excision DNA Repair
Nat.Struct.Biol., 10, 2003
1L1T
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MUTM (FPG) BOUND TO ABASIC-SITE CONTAINING DNA
Descriptor:5'-D(*AP*G*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*TP*GP*C*GP*TP*CP*CP*AP*(HPD)P*GP*TP*CP*TP*AP*CP*C)-3', MutM, ...
Authors:Fromme, J.C., Verdine, G.L.
Deposit date:2002-02-19
Release date:2002-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights into lesion recognition and repair by the bacterial 8-oxoguanine DNA glycosylase MutM.
Nat.Struct.Biol., 9, 2002
1L1Z
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MUTM (FPG) COVALENT-DNA INTERMEDIATE
Descriptor:5'-D(*AP*G*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*TP*GP*C*GP*TP*CP*CP*AP*(PED)P*GP*TP*CP*TP*AP*CP*C)-3', MutM, ...
Authors:Fromme, J.C., Verdine, G.L.
Deposit date:2002-02-20
Release date:2002-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural insights into lesion recognition and repair by the bacterial 8-oxoguanine DNA glycosylase MutM.
Nat.Struct.Biol., 9, 2002
1L2B
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MUTM (FPG) DNA END-PRODUCT STRUCTURE
Descriptor:5'-D(*AP*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*TP*GP*CP*GP*TP*CP*C*(AD2))-3', 5'-D(P*GP*TP*CP*TP*AP*CP*C)-3', ...
Authors:Fromme, J.C., Verdine, G.L.
Deposit date:2002-02-20
Release date:2002-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural insights into lesion recognition and repair by the bacterial 8-oxoguanine DNA glycosylase MutM.
Nat.Struct.Biol., 9, 2002
1L2C
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MUTM (FPG)-DNA ESTRANGED THYMINE MISMATCH RECOGNITION COMPLEX
Descriptor:5'-D(*AP*G*GP*TP*AP*GP*AP*CP*TP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*TP*GP*C*GP*TP*CP*CP*AP*(HPD)P*GP*TP*CP*TP*AP*CP*C)-3', MutM, ...
Authors:Fromme, J.C., Verdine, G.L.
Deposit date:2002-02-20
Release date:2002-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural insights into lesion recognition and repair by the bacterial 8-oxoguanine DNA glycosylase MutM.
Nat.Struct.Biol., 9, 2002
1L2D
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MUTM (FPG)-DNA ESTRANGED GUANINE MISMATCH RECOGNITION COMPLEX
Descriptor:5'-D(*AP*G*GP*TP*AP*GP*AP*CP*GP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*TP*GP*C*GP*TP*CP*CP*AP*(HPD)P*GP*TP*CP*TP*AP*CP*C)-3', MutM, ...
Authors:Fromme, J.C., Verdine, G.L.
Deposit date:2002-02-20
Release date:2002-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insights into lesion recognition and repair by the bacterial 8-oxoguanine DNA glycosylase MutM.
Nat.Struct.Biol., 9, 2002
1LWV
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BOROHYDRIDE-TRAPPED HOGG1 INTERMEDIATE STRUCTURE CO-CRYSTALLIZED WITH 8-AMINOGUANINE
Descriptor:5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*GP*CP*GP*TP*CP*CP*AP*(PED)P*GP*TP*CP*TP*AP*CP*C)-3', 8-OXOGUANINE DNA GLYCOSYLASE, ...
Authors:Fromme, J.C., Bruner, S.D., Yang, W., Karplus, M., Verdine, G.L.
Deposit date:2002-06-03
Release date:2003-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Product-Assisted Catalysis in Base Excision DNA Repair
Nat.Struct.Biol., 10, 2003
1LWW
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BOROHYDRIDE-TRAPPED HOGG1 INTERMEDIATE STRUCTURE CO-CRYSTALLIZED WITH 8-BROMOGUANINE
Descriptor:5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*GP*CP*GP*TP*CP*CP*AP*(PED)P*GP*TP*CP*TP*AP*CP*C)-3', 8-OXOGUANINE DNA GLYCOSYLASE, ...
Authors:Fromme, J.C., Bruner, S.D., Yang, W., Karplus, M., Verdine, G.L.
Deposit date:2002-06-03
Release date:2003-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Product-Assisted Catalysis in Base Excision DNA Repair
Nat.Struct.Biol., 10, 2003
1LWY
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HOGG1 BOROHYDRIDE-TRAPPED INTERMEDIATE WITHOUT 8-OXOGUANINE
Descriptor:5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*GP*CP*GP*TP*CP*CP*AP*(PED)P*GP*TP*CP*TP*AP*CP*C)-3', 8-OXOGUANINE DNA GLYCOSYLASE
Authors:Fromme, J.C., Bruner, S.D., Yang, W., Karplus, M., Verdine, G.L.
Deposit date:2002-06-03
Release date:2003-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Product-Assisted Catalysis in Base Excision DNA Repair
Nat.Struct.Biol., 10, 2003
1M3H
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CRYSTAL STRUCTURE OF HOGG1 D268E MUTANT WITH PRODUCT OLIGONUCLEOTIDE
Descriptor:5'-D(P*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(P*GP*CP*GP*TP*CP*CP*AP*(DDX))-3', 5'-D(P*GP*TP*CP*TP*AP*CP*C)-3', ...
Authors:Chung, S.J., Verdine, G.L.
Deposit date:2002-06-27
Release date:2004-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structures of End Products Resulting from Lesion Processing by a DNA Glycosylase/Lyase
Chem.Biol., 11, 2004
1M3Q
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CRYSTAL STRUCTURE OF HOGG1 D268E MUTANT WITH BASE-EXCISED DNA AND 8-AMINOGUANINE
Descriptor:5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 5'-D(*GP*CP*GP*TP*CP*CP*AP*(DRZ)P*GP*TP*CP*TP*AP*CP*C)-3', 8-oxoguanine DNA glycosylase, ...
Authors:Chung, S.J., Verdine, G.L.
Deposit date:2002-06-28
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of End Products Resulting from Lesion Processing by a DNA Glycosylase/Lyase
Chem.Biol., 11, 2004
1MPG
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3-METHYLADENINE DNA GLYCOSYLASE II FROM ESCHERICHIA COLI
Descriptor:3-METHYLADENINE DNA GLYCOSYLASE II, GLYCEROL
Authors:Labahn, J., Schaerer, O.D., Long, A., Ezaz-Nikpay, K., Verdine, G.L., Ellenberger, T.E.
Deposit date:1997-10-28
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the excision repair of alkylation-damaged DNA.
Cell(Cambridge,Mass.), 86, 1996
1MQ0
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CRYSTAL STRUCTURE OF HUMAN CYTIDINE DEAMINASE
Descriptor:Cytidine Deaminase, ZINC ION, 1-BETA-RIBOFURANOSYL-1,3-DIAZEPINONE
Authors:Chung, S.J., Fromme, J.C., Verdine, G.L.
Deposit date:2002-09-13
Release date:2003-11-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of human cytidine deaminase bound to a potent inhibitor
J.Med.Chem., 48, 2005