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1DWV
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MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER N-HYDROXYARGININE AND 4-AMINO TETRAHYDROBIOPTERIN
Descriptor:NITRIC OXIDE SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE, 2,4-DIAMINO-6-[2,3-DIHYDROXY-PROP-3-YL]-5,6,7,8-TETRAHYDROPTERIDINE, ...
Authors:Crane, B.R., Arvai, A.S., Getzoff, E.D., Stuehr, D.J., Tainer, J.A.
Deposit date:1999-12-14
Release date:2000-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structures of the N(Omega)-Hydroxy-L-Arginine Complex of Inducible Nitric Oxide Synthase Oxygenase Dimer with Active Andinactive Pterins
Biochemistry, 39, 2000
1DWW
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MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER N-HYDROXYARGININE AND DIHYDROBIOPTERIN
Descriptor:NITRIC OXIDE SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE, 2-AMINO-6-(1,2-DIHYDROXY-PROPYL)-7,8-DIHYDRO-6H-PTERIDIN-4-ONE, ...
Authors:Crane, B.R., Arvai, A.S., Getzoff, E.D., Stuehr, D.J., Tainer, J.A.
Deposit date:1999-12-14
Release date:2000-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structures of the N(Omega)-Hydroxy-L-Arginine Complex of Inducible Nitric Oxide Synthase Oxygenase Dimer with Active Andinactive Pterins
Biochemistry, 39, 2000
1DWX
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MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER N-HYDROXYARGININE AND TETRAHYDROBIOPTERIN
Descriptor:NITRIC OXIDE SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Crane, B.R., Arvai, A.S., Getzoff, E.D., Stuehr, D.J., Tainer, J.A.
Deposit date:1999-12-14
Release date:2000-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of the N(Omega)-Hydroxy-L-Arginine Complex of Inducible Nitric Oxide Synthase Oxygenase Dimer with Active Andinactive Pterins
Biochemistry, 39, 2000
1QOM
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MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER (DELTA 65) WITH SWAPPED N-TERMINAL HOOK
Descriptor:NITRIC OXIDE SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN
Authors:Crane, B.R., Rosenfeld, R.A., Arvai, A.S., Tainer, J.A., Stuehr, D.J., Getzoff, E.D.
Deposit date:1999-11-15
Release date:1999-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:N-Terminal Domain Swapping and Metal Ion Binding in Nitric Oxide Synthase Dimerization
Embo J., 18, 1999
1NOD
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MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER (DELTA 65) WITH TETRAHYDROBIOPTERIN AND SUBSTRATE L-ARGININE
Descriptor:NITRIC OXIDE SYNTHASE, SULFATE ION, ARGININE, ...
Authors:Crane, B.R., Arvai, A.S., Getzoff, E.D., Stuehr, D.J., Tainer, J.A.
Deposit date:1998-03-05
Release date:1999-03-23
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.
Science, 279, 1998
2NOD
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MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER (DELTA 65) WITH TETRAHYDROBIOPTERIN AND WATER BOUND IN ACTIVE CENTER
Descriptor:NITRIC OXIDE SYNTHASE, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Crane, B.R., Arvai, A.S., Getzoff, E.D., Stuehr, D.J., Tainer, J.A.
Deposit date:1998-03-05
Release date:1999-03-23
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.
Science, 279, 1998
3NOD
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MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER (DELTA 65) WITH TETRAHYDROBIOPTERIN AND PRODUCT ANALOGUE L-THIOCITRULLINE
Descriptor:NITRIC OXIDE SYNTHASE, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Crane, B.R., Arvai, A.S., Getzoff, E.D., Stuehr, D.J., Tainer, J.A.
Deposit date:1998-03-06
Release date:1999-03-23
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.
Science, 279, 1998
1DF1
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MURINE INOSOXY DIMER WITH ISOTHIOUREA BOUND IN THE ACTIVE SITE
Descriptor:NITRIC OXIDE SYNTHASE, ZINC ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Crane, B.R., Rosenfeld, R.J., Arvai, A.S., Ghosh, D.K., Ghosh, S., Tainer, J.A., Stuehr, D.J., Getzoff, E.D.
Deposit date:1999-11-16
Release date:1999-12-08
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization.
EMBO J., 18, 1999
1JWJ
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MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER (DELTA 65) WITH W457F MUTATION AT TETRAHYDROBIOPTERIN BINDING SITE
Descriptor:Nitric Oxide Synthase, B-OCTYLGLUCOSIDE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Aoyagi, M., Arvai, A.S., Ghosh, S., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2001-09-04
Release date:2001-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457.
Biochemistry, 40, 2001
1JWK
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MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER (DELTA 65) WITH W457A MUTATION AT TETRAHYDROBIOPTERIN BINDING SITE
Descriptor:Nitric Oxide Synthase, Inducible, B-OCTYLGLUCOSIDE, ...
Authors:Aoyagi, M., Arvai, A.S., Ghosh, S., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2001-09-04
Release date:2001-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457.
Biochemistry, 40, 2001
1M8D
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INDUCIBLE NITRIC OXIDE SYNTHASE WITH CHLORZOXAZONE BOUND
Descriptor:Inducible Nitric Oxide Synthase, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2002-07-24
Release date:2002-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M8E
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INDUCIBLE NITRIC OXIDE SYNTHASE WITH 7-NITROINDAZOLE BOUND
Descriptor:inducible Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2002-07-24
Release date:2002-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M8H
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INDUCIBLE NITRIC OXIDE SYNTHASE WITH 6-NITROINDAZOLE BOUND
Descriptor:inducible Nitric oxide synthase, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2002-07-24
Release date:2002-08-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M8I
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INDUCIBLE NITRIC OXIDE SYNTHASE WITH 5-NITROINDAZOLE BOUND
Descriptor:inducible Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2002-07-24
Release date:2002-08-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M9J
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HUMAN ENDOTHELIAL NITRIC OXIDE SYNTHASE WITH CHLORZOXAZONE BOUND
Descriptor:endothelial Nitric-oxide synthase, ZINC ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2002-07-29
Release date:2002-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M9K
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HUMAN ENDOTHELIAL NITRIC OXIDE SYNTHASE WITH 7-NITROINDAZOLE BOUND
Descriptor:endothelial Nitric-oxide synthase, ZINC ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2002-07-29
Release date:2002-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M9M
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HUMAN ENDOTHELIAL NITRIC OXIDE SYNTHASE WITH 6-NITROINDAZOLE BOUND
Descriptor:endothelial Nitric-oxide synthase, ZINC ION, SODIUM ION, ...
Authors:Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2002-07-29
Release date:2002-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M9Q
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HUMAN ENDOTHELIAL NITRIC OXIDE SYNTHASE WITH 5-NITROINDAZOLE BOUND
Descriptor:endothelial Nitric-oxide synthase, ZINC ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2002-07-29
Release date:2002-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M9R
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HUMAN ENDOTHELIAL NITRIC OXIDE SYNTHASE WITH 3-BROMO-7-NITROINDAZOLE BOUND
Descriptor:endothelial Nitric-oxide synthase, ZINC ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2002-07-29
Release date:2002-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1M9T
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INDUCIBLE NITRIC OXIDE SYNTHASE WITH 3-BROMO-7-NITROINDAZOLE BOUND
Descriptor:inducible nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Rosenfeld, R.J., Garcin, E.D., Panda, K., Andersson, G., Aberg, A., Wallace, A.V., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2002-09-05
Release date:2002-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency
Biochemistry, 41, 2002
1NOC
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MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DOMAIN (DELTA 114) COMPLEXED WITH TYPE I E. COLI CHLORAMPHENICOL ACETYL TRANSFERASE AND IMIDAZOLE
Descriptor:INDUCIBLE NITRIC OXIDE SYNTHASE, TYPE 1 CHLORAMPHENICOL ACETYLTRANSFERASE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Crane, B.R., Arvai, A.S., Getzoff, E.D., Stuehr, D.J., Tainer, J.A.
Deposit date:1997-09-28
Release date:1998-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structure of nitric oxide synthase oxygenase domain and inhibitor complexes.
Science, 278, 1997
1NOS
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MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DOMAIN (DELTA 114), IMIDAZOLE COMPLEX
Descriptor:INDUCIBLE NITRIC OXIDE SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE, IMIDAZOLE
Authors:Crane, B.R., Arvai, A.S., Getzoff, E.D., Stuehr, D.J., Tainer, J.A.
Deposit date:1997-09-28
Release date:1998-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of nitric oxide synthase oxygenase domain and inhibitor complexes.
Science, 278, 1997
2NOS
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MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DOMAIN (DELTA 114), AMINOGUANIDINE COMPLEX
Descriptor:INDUCIBLE NITRIC OXIDE SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE, IMIDAZOLE, ...
Authors:Crane, B.R., Arvai, A.S., Getzoff, E.D., Stuehr, D.J., Tainer, J.A.
Deposit date:1997-09-28
Release date:1998-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of nitric oxide synthase oxygenase domain and inhibitor complexes.
Science, 278, 1997
1TLL
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CRYSTAL STRUCTURE OF RAT NEURONAL NITRIC-OXIDE SYNTHASE REDUCTASE MODULE AT 2.3 A RESOLUTION.
Descriptor:Nitric-oxide synthase, brain, SULFITE ION, ...
Authors:Garcin, E.D., Bruns, C.M., Lloyd, S.J., Hosfield, D.J., Tiso, M., Gachhui, R., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2004-06-09
Release date:2004-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase
J.Biol.Chem., 279, 2004
3E7I
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STRUCTURE OF MURINE INOS OXYGENASE DOMAIN WITH INHIBITOR AR-C94864
Descriptor:Nitric oxide synthase, inducible, SULFATE ION, ...
Authors:Garcin, E.D., Arvai, A.S., Rosenfeld, R.J., Kroeger, M.D., Crane, B.R., Andersson, G., Andrews, G., Hamley, P.J., Mallinder, P.R., Nicholls, D.J., St-Gallay, S.A., Tinker, A.C., Gensmantel, N.P., Mete, A., Cheshire, D.R., Connolly, S., Stuehr, D.J., Aberg, A., Wallace, A.V., Tainer, J.A., Getzoff, E.D.
Deposit date:2008-08-18
Release date:2008-10-07
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.
Nat.Chem.Biol., 4, 2008