Author results

2AL7
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STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR-LIKE 10C
Descriptor:ADP-ribosylation factor-like 10C, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Ismail, S., Dimov, S., Atanassova, A., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2005-08-04
Release date:2005-08-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:GTP-like conformation of GDP-bound ARL10C GTPase
To be Published
6C2F
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MBD2 IN COMPLEX WITH METHYLATED DNA
Descriptor:Methyl-CpG-binding domain protein 2, 12-mer DNA, UNKNOWN ATOM OR ION
Authors:Liu, K., Xu, C., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2018-01-08
Release date:2018-02-14
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:MBD2 in complex with methylated DNA
to be published
6OQM
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CRYSTAL STRUCTURE OF THE MSH6 PWWP DOMAIN
Descriptor:DNA mismatch repair protein Msh6, UNKNOWN ATOM OR ION, MAGNESIUM ION, ...
Authors:Qin, S., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2019-04-26
Release date:2019-05-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:crystal structure of the MSH6 PWWP domain
To Be Published
3QVE
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CRYSTAL STRUCTURE OF HUMAN HMG BOX-CONTAINING PROTEIN 1, HBP1
Descriptor:HMG box-containing protein 1, SULFATE ION, 1,2-ETHANEDIOL
Authors:Chaikuad, A., Krysztofinska, E., Cocking, R., Vollmar, M., Yue, W.W., Krojer, T., Ugochukwu, E., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Bountra, C., Oppermann, U., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2011-02-25
Release date:2011-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Crystal structure of human HMG box-containing protein 1, HBP1
To be Published
3N3K
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THE CATALYTIC DOMAIN OF USP8 IN COMPLEX WITH A USP8 SPECIFIC INHIBITOR
Descriptor:Ubiquitin carboxyl-terminal hydrolase 8, Ubiquitin, ZINC ION
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Li, Y., Allali-Hassani, A., Lam, R., Ernst, A., Sidhu, S., Weigelt, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2010-05-20
Release date:2010-06-23
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
6OAW
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CRYSTAL STRUCTURE OF A CRISPR CAS-RELATED PROTEIN
Descriptor:WYL1, UNKNOWN ATOM OR ION
Authors:Zhang, H., Dong, C., Li, L., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2019-03-18
Release date:2019-04-10
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural insights into the modulatory role of the accessory protein WYL1 in the Type VI-D CRISPR-Cas system.
Nucleic Acids Res., 47, 2019
6OGK
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MECP2 MBD IN COMPLEX WITH DNA
Descriptor:Methyl-CpG-binding protein 2, DNA (5'-D(*GP*CP*CP*TP*AP*(5CM)P*AP*CP*TP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*AP*GP*TP*GP*TP*AP*GP*GP*C)-3'), ...
Authors:Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2019-04-02
Release date:2019-05-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:MeCP2 MBD in complex with DNA
To Be Published
6QAS
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CRYSTAL STRUCTURE OF ULK1 IN COMPLEXED WITH PF-03814735
Descriptor:Serine/threonine-protein kinase ULK1, SULFATE ION, CITRIC ACID, ...
Authors:Chaikuad, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2018-12-19
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).
Biochem.J., 476, 2019
6QAT
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CRYSTAL STRUCTURE OF ULK2 IN COMPLEXED WITH HESPERADIN
Descriptor:Serine/threonine-protein kinase ULK2, N-{(3Z)-2-oxo-3-[phenyl({4-[(piperidin-1-yl)methyl]phenyl}amino)methylidene]-2,3-dihydro-1H-indol-5-yl}ethanesulfonamide
Authors:Chaikuad, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2018-12-19
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).
Biochem.J., 476, 2019
6QAU
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CRYSTAL STRUCTURE OF ULK2 IN COMPLEXED WITH MRT67307
Descriptor:Serine/threonine-protein kinase ULK2, N-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide, 1,2-ETHANEDIOL, ...
Authors:Chaikuad, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2018-12-19
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).
Biochem.J., 476, 2019
6QAV
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CRYSTAL STRUCTURE OF ULK2 IN COMPLEXED WITH MRT68921
Descriptor:Serine/threonine-protein kinase ULK2, ~{N}-[3-[[5-cyclopropyl-2-[(2-methyl-3,4-dihydro-1~{H}-isoquinolin-6-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide, 1,2-ETHANEDIOL, ...
Authors:Chaikuad, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2018-12-19
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).
Biochem.J., 476, 2019
3EAP
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CRYSTAL STRUCTURE OF THE RHOGAP DOMAIN OF ARHGAP11A
Descriptor:Rho GTPase-activating protein 11A, UNKNOWN ATOM OR ION
Authors:Shen, Y., Shen, L., Tong, Y., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2008-08-26
Release date:2008-09-02
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the RhoGAP domain of ARHGAP11A
To be Published