6QAV
Crystal structure of ULK2 in complexed with MRT68921
Summary for 6QAV
Entry DOI | 10.2210/pdb6qav/pdb |
Descriptor | Serine/threonine-protein kinase ULK2, ~{N}-[3-[[5-cyclopropyl-2-[(2-methyl-3,4-dihydro-1~{H}-isoquinolin-6-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | ulk2, autophagy, kinase, inhibitor complex, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 129947.39 |
Authors | Chaikuad, A.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium,Structural Genomics Consortium (SGC) (deposition date: 2018-12-19, release date: 2019-02-27, Last modification date: 2024-01-24) |
Primary citation | Chaikuad, A.,Koschade, S.E.,Stolz, A.,Zivkovic, K.,Pohl, C.,Shaid, S.,Ren, H.,Lambert, L.J.,Cosford, N.D.P.,Brandts, C.H.,Knapp, S. Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2). Biochem.J., 476:875-887, 2019 Cited by PubMed: 30782972DOI: 10.1042/BCJ20190038 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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