6QAV
Crystal structure of ULK2 in complexed with MRT68921
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Serine/threonine-protein kinase ULK2 | polymer | 280 | 31767.7 | 4 | UniProt (Q8IYT8) Pfam (PF00069) | Homo sapiens (Human) | Unc-51-like kinase 2 |
| 2 | E, J, Q, V (A, B, C, D) | ~{N}-[3-[[5-cyclopropyl-2-[(2-methyl-3,4-dihydro-1~{H}-isoquinolin-6-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide | non-polymer | 434.6 | 4 | Chemie (HVH) | |||
| 3 | F, G, H, I, L... (A, B, C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 15 | Chemie (EDO) | |||
| 4 | K (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | P, U (B, C) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | AA, BA, CA, DA (A, B, C, D) | water | water | 18.0 | 357 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 276 (UniProt: Q8IYT8)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Asp 173 | Thr 173 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 127070.9 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 2876.5 | |
| All* | Total formula weight | 129947.4 |
