7BF4

Crystal structure of SARS-CoV-2 macrodomain in complex with GMP

Summary for 7BF4

Entry DOI	10.2210/pdb7bf4/pdb
Descriptor	NSP3 macrodomain, GUANOSINE-5'-MONOPHOSPHATE, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	nsp3, macrodomain, sars-cov-2, gmp, guanosine monophosphate, covid-19, structural genomics, structural genomics consortium, sgc, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
Total number of polymer chains	1
Total formula weight	19598.21
Authors	Ni, X.,Knapp, S.,Chaikuad, A.,Structural Genomics Consortium,Structural Genomics Consortium (SGC) (deposition date: 2020-12-31, release date: 2021-01-13, Last modification date: 2024-01-31)
Primary citation	Ni, X.,Schroder, M.,Olieric, V.,Sharpe, M.E.,Hernandez-Olmos, V.,Proschak, E.,Merk, D.,Knapp, S.,Chaikuad, A. Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain. Acs Med.Chem.Lett., 12:603-609, 2021 Cited by PubMed: 33850605 DOI: 10.1021/acsmedchemlett.0c00684 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation