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1MBO
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STRUCTURE AND REFINEMENT OF OXYMYOGLOBIN AT 1.6 ANGSTROMS RESOLUTION
Descriptor:MYOGLOBIN, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Phillips, S.E.V.
Deposit date:1981-08-27
Release date:1982-02-03
Last modified:2014-03-05
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure and refinement of oxymyoglobin at 1.6 A resolution.
J.Mol.Biol., 142, 1980
4TLN
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BINDING OF HYDROXAMIC ACID INHIBITORS TO CRYSTALLINE THERMOLYSIN SUGGESTS A PENTACOORDINATE ZINC INTERMEDIATE IN CATALYSIS
Descriptor:THERMOLYSIN, CALCIUM ION, ZINC ION, ...
Authors:Matthews, B.W., Holmes, M.A.
Deposit date:1982-02-08
Release date:1982-05-26
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Binding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysis.
Biochemistry, 20, 1981
5TLN
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BINDING OF HYDROXAMIC ACID INHIBITORS TO CRYSTALLINE THERMOLYSIN SUGGESTS A PENTACOORDINATE ZINC INTERMEDIATE IN CATALYSIS
Descriptor:THERMOLYSIN, CALCIUM ION, ZINC ION, ...
Authors:Matthews, B.W., Holmes, M.A.
Deposit date:1982-02-08
Release date:1982-05-26
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Binding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysis.
Biochemistry, 20, 1981
7TLN
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STRUCTURAL ANALYSIS OF THE INHIBITION OF THERMOLYSIN BY AN ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITOR
Descriptor:THERMOLYSIN, CALCIUM ION, ZINC ION, ...
Authors:Matthews, B.W., Holmes, M.A., Tronrud, D.E.
Deposit date:1983-01-27
Release date:1983-03-09
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural analysis of the inhibition of thermolysin by an active-site-directed irreversible inhibitor.
Biochemistry, 22, 1983
1TLP
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CRYSTALLOGRAPHIC STRUCTURAL ANALYSIS OF PHOSPHORAMIDATES AS INHIBITORS AND TRANSITION-STATE ANALOGS OF THERMOLYSIN
Descriptor:THERMOLYSIN, N-ALPHA-L-RHAMNOPYRANOSYLOXY(HYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN, CALCIUM ION, ...
Authors:Tronrud, D.E., Monzingo, A.F., Matthews, B.W.
Deposit date:1987-06-29
Release date:1989-01-09
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystallographic structural analysis of phosphoramidates as inhibitors and transition-state analogs of thermolysin.
Eur.J.Biochem., 157, 1986
1TMN
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BINDING OF N-CARBOXYMETHYL DIPEPTIDE INHIBITORS TO THERMOLYSIN DETERMINED BY X-RAY CRYSTALLOGRAPHY. A NOVEL CLASS OF TRANSITION-STATE ANALOGUES FOR ZINC PEPTIDASES
Descriptor:THERMOLYSIN, N-[(1R)-1-carboxy-3-phenylpropyl]-L-leucyl-L-tryptophan, CALCIUM ION, ...
Authors:Monzingo, A.F., Matthews, B.W.
Deposit date:1987-06-29
Release date:1989-01-09
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Binding of N-carboxymethyl dipeptide inhibitors to thermolysin determined by X-ray crystallography: a novel class of transition-state analogues for zinc peptidases
Biochemistry, 23, 1984
2TMN
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CRYSTALLOGRAPHIC STRUCTURAL ANALYSIS OF PHOSPHORAMIDATES AS INHIBITORS AND TRANSITION-STATE ANALOGS OF THERMOLYSIN
Descriptor:Thermolysin, CALCIUM ION, ZINC ION, ...
Authors:Tronrud, D.E., Monzingo, A.F., Matthews, B.W.
Deposit date:1987-06-29
Release date:1989-01-09
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystallographic structural analysis of phosphoramidates as inhibitors and transition-state analogs of thermolysin.
Eur.J.Biochem., 157, 1986
3TMN
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THE BINDING OF L-VALYL-L-TRYPTOPHAN TO CRYSTALLINE THERMOLYSIN ILLUSTRATES THE MODE OF INTERACTION OF A PRODUCT OF PEPTIDE HYDROLYSIS
Descriptor:THERMOLYSIN, VALINE, TRYPTOPHAN, ...
Authors:Holden, H.M., Matthews, B.W.
Deposit date:1987-06-29
Release date:1989-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The binding of L-valyl-L-tryptophan to crystalline thermolysin illustrates the mode of interaction of a product of peptide hydrolysis.
J.Biol.Chem., 263, 1988
4TMN
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SLOW-AND FAST-BINDING INHIBITORS OF THERMOLYSIN DISPLAY DIFFERENT MODES OF BINDING. CRYSTALLOGRAPHIC ANALYSIS OF EXTENDED PHOSPHONAMIDATE TRANSITION-STATE ANALOGUES
Descriptor:THERMOLYSIN, N-[(S)-[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl]-L-leucyl-L-alanine, CALCIUM ION, ...
Authors:Holden, H.M., Tronrud, D.E., Monzingo, A.F., Weaver, L.H., Matthews, B.W.
Deposit date:1987-06-29
Release date:1989-01-09
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Slow- and fast-binding inhibitors of thermolysin display different modes of binding: crystallographic analysis of extended phosphonamidate transition-state analogues.
Biochemistry, 26, 1987
5TMN
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SLOW-AND FAST-BINDING INHIBITORS OF THERMOLYSIN DISPLAY DIFFERENT MODES OF BINDING. CRYSTALLOGRAPHIC ANALYSIS OF EXTENDED PHOSPHONAMIDATE TRANSITION-STATE ANALOGUES
Descriptor:THERMOLYSIN, N-[(S)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-leucyl-L-leucine, CALCIUM ION, ...
Authors:Holden, H.M., Tronrud, D.E., Monzingo, A.F., Weaver, L.H., Matthews, B.W.
Deposit date:1987-06-29
Release date:1989-01-09
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Slow- and fast-binding inhibitors of thermolysin display different modes of binding: crystallographic analysis of extended phosphonamidate transition-state analogues.
Biochemistry, 26, 1987
6TMN
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STRUCTURES OF TWO THERMOLYSIN-INHIBITOR COMPLEXES THAT DIFFER BY A SINGLE HYDROGEN BOND
Descriptor:THERMOLYSIN, N-[(2R,4S)-4-hydroxy-2-(2-methylpropyl)-4-oxido-7-oxo-9-phenyl-3,8-dioxa-6-aza-4-phosphanonan-1-oyl]-L-leucine, CALCIUM ION, ...
Authors:Tronrud, D.E., Holden, H.M., Matthews, B.W.
Deposit date:1987-06-29
Release date:1989-01-09
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of two thermolysin-inhibitor complexes that differ by a single hydrogen bond.
Science, 235, 1987
2MB5
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HYDRATION IN PROTEIN CRYSTALS. A NEUTRON DIFFRACTION ANALYSIS OF CARBONMONOXYMYOGLOBIN
Descriptor:MYOGLOBIN, SULFATE ION, AMMONIUM CATION WITH D, ...
Authors:Schoenborn, B.P., Cheng, X.
Deposit date:1989-10-11
Release date:1991-04-15
Last modified:2011-07-13
Method:NEUTRON DIFFRACTION (1.8 Å)
Cite:Hydration in Protein Crystals. A Neutron Diffraction Analysis of Carbonmonoxymyoglobin
Acta Crystallogr.,Sect.B, 46, 1990
8TLN
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STRUCTURAL COMPARISON SUGGESTS THAT THERMOLYSIN AND RELATED NEUTRAL PROTEASES UNDERGO HINGE-BENDING MOTION DURING CATALYSIS
Descriptor:THERMOLYSIN, VALINE, LYSINE, ...
Authors:Tronrud, D., Matthews, B.W.
Deposit date:1993-09-01
Release date:1994-04-30
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural comparison suggests that thermolysin and related neutral proteases undergo hinge-bending motion during catalysis.
Biochemistry, 31, 1992
1THL
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THERMOLYSIN COMPLEXED WITH A NOVEL GLUTARAMIDE DERIVATIVE, N-(1-(2(R,S)-CARBOXY-4-PHENYLBUTYL) CYCLOPENTYLCARBONYL)-(S)-TRYPTOPHAN
Descriptor:THERMOLYSIN, CALCIUM ION, ZINC ION, ...
Authors:Holland, D.R., Matthews, B.W.
Deposit date:1993-11-17
Release date:1994-01-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Inhibition of Thermolysin and Neutral Endopeptidase 24.11 By a Novel Glutaramide Derivative; X-Ray Structure Determination of the Thermolysin-Inhibitor Complex
Biochemistry, 33, 1994
1HYT
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RE-DETERMINATION AND REFINEMENT OF THE COMPLEX OF BENZYLSUCCINIC ACID WITH THERMOLYSIN AND ITS RELATION TO THE COMPLEX WITH CARBOXYPEPTIDASE A
Descriptor:THERMOLYSIN, CALCIUM ION, ZINC ION, ...
Authors:Hausrath, A.C., Matthews, B.W.
Deposit date:1994-05-04
Release date:1994-07-31
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Redetermination and refinement of the complex of benzylsuccinic acid with thermolysin and its relation to the complex with carboxypeptidase A.
J.Biol.Chem., 269, 1994
1LNA
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A STRUCTURAL ANALYSIS OF METAL SUBSTITUTIONS IN THERMOLYSIN
Descriptor:THERMOLYSIN, VALINE, LYSINE, ...
Authors:Holland, D.R., Hausrath, A.C., Juers, D., Matthews, B.W.
Deposit date:1994-05-13
Release date:1995-05-08
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of zinc substitutions in the active site of thermolysin.
Protein Sci., 4, 1995
1LNB
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A STRUCTURAL ANALYSIS OF METAL SUBSTITUTIONS IN THERMOLYSIN
Descriptor:THERMOLYSIN, VALINE, LYSINE, ...
Authors:Holland, D.R., Hausrath, A.C., Juers, D., Matthews, B.W.
Deposit date:1994-05-13
Release date:1995-05-08
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural analysis of zinc substitutions in the active site of thermolysin.
Protein Sci., 4, 1995
1LNC
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A STRUCTURAL ANALYSIS OF METAL SUBSTITUTIONS IN THERMOLYSIN
Descriptor:THERMOLYSIN, VALINE, LYSINE, ...
Authors:Holland, D.R., Hausrath, A.C., Juers, D., Matthews, B.W.
Deposit date:1994-05-13
Release date:1995-05-08
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural analysis of zinc substitutions in the active site of thermolysin.
Protein Sci., 4, 1995
1LND
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A STRUCTURAL ANALYSIS OF METAL SUBSTITUTIONS IN THERMOLYSIN
Descriptor:THERMOLYSIN, VALINE, LYSINE, ...
Authors:Holland, D.R., Hausrath, A.C., Juers, D., Matthews, B.W.
Deposit date:1994-05-13
Release date:1995-05-08
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural analysis of zinc substitutions in the active site of thermolysin.
Protein Sci., 4, 1995
1LNE
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A STRUCTURAL ANALYSIS OF METAL SUBSTITUTIONS IN THERMOLYSIN
Descriptor:THERMOLYSIN, VALINE, LYSINE, ...
Authors:Holland, D.R., Hausrath, A.C., Juers, D., Matthews, B.W.
Deposit date:1994-05-13
Release date:1995-05-08
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural analysis of zinc substitutions in the active site of thermolysin.
Protein Sci., 4, 1995
1LNF
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A STRUCTURAL ANALYSIS OF METAL SUBSTITUTIONS IN THERMOLYSIN
Descriptor:THERMOLYSIN, VALINE, LYSINE, ...
Authors:Holland, D.R., Matthews, B.W.
Deposit date:1994-05-13
Release date:1995-05-08
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural analysis of zinc substitutions in the active site of thermolysin.
Protein Sci., 4, 1995
1QF0
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THERMOLYSIN (E.C.3.4.24.27) COMPLEXED WITH (2-SULPHANYL-3-PHENYLPROPANOYL)-PHE-TYR. PARAMETERS FOR ZN-BIDENTATION OF MERCAPTOACYLDIPEPTIDES IN METALLOENDOPEPTIDASE
Descriptor:PROTEIN (THERMOLYSIN), ZINC ION, CALCIUM ION, ...
Authors:Gaucher, J.-F., Selkti, M., Tiraboschi, G., Prange, T., Roques, B.P., Tomas, A., Fournie-Zaluski, M.C.
Deposit date:1999-04-06
Release date:1999-12-29
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of alpha-mercaptoacyldipeptides in the thermolysin active site: structural parameters for a Zn monodentation or bidentation in metalloendopeptidases.
Biochemistry, 38, 1999
1QF1
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THERMOLYSIN (E.C.3.4.24.27) COMPLEXED WITH (2-SULPHANYLHEPTANOYL)-PHE-ALA. PARAMETERS FOR ZN-BIDENTATION OF MERCAPTOACYLDIPEPTIDES IN METALLOENDOPEPTIDASE
Descriptor:PROTEIN (THERMOLYSIN), ZINC ION, CALCIUM ION, ...
Authors:Gaucher, J.-F., Selkti, M., Tiraboschi, G., Prange, T., Roques, B.P., Tomas, A., Fournie-Zaluski, M.C.
Deposit date:1999-04-06
Release date:1999-12-29
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of alpha-mercaptoacyldipeptides in the thermolysin active site: structural parameters for a Zn monodentation or bidentation in metalloendopeptidases.
Biochemistry, 38, 1999
1QF2
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THERMOLYSIN (E.C.3.4.24.27) COMPLEXED WITH (2-SULPHANYL-3-PHENYLPROPANOYL)-GLY-(5-PHENYLPROLINE). PARAMETERS FOR ZN-MONODENTATION OF MERCAPTOACYLDIPEPTIDES IN METALLOENDOPEPTIDASE
Descriptor:PROTEIN (THERMOLYSIN), ZINC ION, CALCIUM ION, ...
Authors:Gaucher, J.-F., Selkti, M., Tiraboschi, G., Prange, T., Roques, B.P., Tomas, A., Fournie-Zaluski, M.C.
Deposit date:1999-04-06
Release date:1999-12-29
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Crystal structures of alpha-mercaptoacyldipeptides in the thermolysin active site: structural parameters for a Zn monodentation or bidentation in metalloendopeptidases.
Biochemistry, 38, 1999
1CQ2
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NEUTRON STRUCTURE OF FULLY DEUTERATED SPERM WHALE MYOGLOBIN AT 2.0 ANGSTROM
Descriptor:MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE
Authors:Shu, F., Ramakrishnan, V., Schoenborn, B.P.
Deposit date:1999-08-04
Release date:1999-08-16
Last modified:2017-10-04
Method:NEUTRON DIFFRACTION (2 Å)
Cite:Enhanced visibility of hydrogen atoms by neutron crystallography on fully deuterated myoglobin.
Proc.Natl.Acad.Sci.USA, 97, 2000
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