4TLN

BINDING OF HYDROXAMIC ACID INHIBITORS TO CRYSTALLINE THERMOLYSIN SUGGESTS A PENTACOORDINATE ZINC INTERMEDIATE IN CATALYSIS

Summary for 4TLN

Entry DOI	10.2210/pdb4tln/pdb
Descriptor	THERMOLYSIN, CALCIUM ION, ZINC ION, ... (5 entities in total)
Functional Keywords	hydrolase (metalloproteinase)
Biological source	Bacillus thermoproteolyticus
Total number of polymer chains	1
Total formula weight	34734.21
Authors	Matthews, B.W.,Holmes, M.A. (deposition date: 1982-02-08, release date: 1982-05-26, Last modification date: 2024-05-22)
Primary citation	Holmes, M.A.,Matthews, B.W. Binding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysis. Biochemistry, 20:6912-6920, 1981 Cited by PubMed: 7317361 DOI: 10.1021/bi00527a026 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation