5TMN

Slow-and fast-binding inhibitors of thermolysin display different modes of binding. crystallographic analysis of extended phosphonamidate transition-state analogues

Summary for 5TMN

• Entry DOI: 10.2210/pdb5tmn/pdb
• Related: 4TMN
• Related PRD ID: PRD_000654
• Descriptor: THERMOLYSIN, N-[(S)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-leucyl-L-leucine, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: metalloproteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Bacillus thermoproteolyticus
• Cellular location: Secreted: P00800
• Total number of polymer chains: 1
• Total formula weight: 35059.51

Authors

Holden, H.M.,Tronrud, D.E.,Monzingo, A.F.,Weaver, L.H.,Matthews, B.W. (deposition date: 1987-06-29, release date: 1989-01-09, Last modification date: 2022-11-23)

• Primary citation: Holden, H.M.,Tronrud, D.E.,Monzingo, A.F.,Weaver, L.H.,Matthews, B.W.; Slow- and fast-binding inhibitors of thermolysin display different modes of binding: crystallographic analysis of extended phosphonamidate transition-state analogues.; Biochemistry, 26:8542-8553, 1987; PubMed: 3442675; DOI: 10.1021/bi00400a008

Experimental method

X-RAY DIFFRACTION (1.6 Å)