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1GOW
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BU of 1gow by Molmil
BETA-GLYCOSIDASE FROM SULFOLOBUS SOLFATARICUS
Descriptor: BETA-GLYCOSIDASE
Authors:Pearl, L.H, Aguilar, C.F, Sanderson, I.
Deposit date:1996-09-19
Release date:1997-08-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the beta-glycosidase from the hyperthermophilic archeon Sulfolobus solfataricus: resilience as a key factor in thermostability.
J.Mol.Biol., 271, 1997
1QNL
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BU of 1qnl by Molmil
AMIDE RECEPTOR/NEGATIVE REGULATOR OF THE AMIDASE OPERON OF PSEUDOMONAS AERUGINOSA (AMIC) COMPLEXED WITH BUTYRAMIDE
Descriptor: ALIPHATIC AMIDASE EXPRESSION-REGULATING PROTEIN, BUTYRAMIDE
Authors:Pearl, L.H, O'Hara, B.P, Roe, S.M.
Deposit date:1999-10-19
Release date:1999-12-23
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Adaptation to Selective Pressure for Altered Ligand Specificity in the Pseudomonas Aeruginosa Amide Receptor, Amic
Protein Eng., 13, 2000
1QO0
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BU of 1qo0 by Molmil
Amide receptor of the amidase operon of Pseudomonas aeruginosa (AmiC) complexed with the negative regulator AmiR.
Descriptor: AMIC, AMIR, BUTYRAMIDE
Authors:Pearl, L.H, O'Hara, B.P, Roe, S.M.
Deposit date:1999-10-26
Release date:1999-12-23
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure and Induction Mechanism of Amic-Amir: A Ligand-Regulated Transcription Antitermination Complex
Embo J., 18, 1999
1UDI
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BU of 1udi by Molmil
NUCLEOTIDE MIMICRY IN THE CRYSTAL STRUCTURE OF THE URACIL-DNA GLYCOSYLASE-URACIL GLYCOSYLASE INHIBITOR PROTEIN COMPLEX
Descriptor: URACIL-DNA GLYCOSYLASE, URACIL-DNA GLYCOSYLASE INHIBITOR PROTEIN
Authors:Pearl, L.H, Savva, R.
Deposit date:1995-10-30
Release date:1996-03-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Nucleotide mimicry in the crystal structure of the uracil-DNA glycosylase-uracil glycosylase inhibitor protein complex.
Nat.Struct.Biol., 2, 1995
1GXR
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BU of 1gxr by Molmil
WD40 Region of Human Groucho/TLE1
Descriptor: CALCIUM ION, TRANSDUCIN-LIKE ENHANCER PROTEIN 1
Authors:Pearl, L.H, Roe, S.M, Pickles, L.M.
Deposit date:2002-04-10
Release date:2002-06-13
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structure of the C-Terminal Wd40 Repeat Domain of the Human Groucho/Tle1 Transcriptional Corepressor
Structure, 10, 2002
1PEA
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BU of 1pea by Molmil
AMIDE RECEPTOR/NEGATIVE REGULATOR OF THE AMIDASE OPERON OF PSEUDOMONAS AERUGINOSA (AMIC) COMPLEXED WITH ACETAMIDE
Descriptor: ACETAMIDE, AMIDASE OPERON
Authors:Pearl, L.H, O'Hara, B.P.
Deposit date:1995-11-16
Release date:1996-04-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of AmiC: the controller of transcription antitermination in the amidase operon of Pseudomonas aeruginosa.
EMBO J., 13, 1994
1UDH
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BU of 1udh by Molmil
THE STRUCTURAL BASIS OF SPECIFIC BASE EXCISION REPAIR BY URACIL-DNA GLYCOSYLASE
Descriptor: SULFATE ION, URACIL, URACIL-DNA GLYCOSYLASE
Authors:Pearl, L.H, Savva, R.
Deposit date:1995-10-30
Release date:1996-03-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The structural basis of specific base-excision repair by uracil-DNA glycosylase.
Nature, 373, 1995
1UDG
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BU of 1udg by Molmil
THE STRUCTURAL BASIS OF SPECIFIC BASE EXCISION REPAIR BY URACIL-DNA GLYCOSYLASE
Descriptor: SULFATE ION, URACIL-DNA GLYCOSYLASE
Authors:Pearl, L.H, Savva, R.
Deposit date:1995-06-23
Release date:1996-01-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The structural basis of specific base-excision repair by uracil-DNA glycosylase.
Nature, 373, 1995
4APE
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BU of 4ape by Molmil
THE ACTIVE SITE OF ASPARTIC PROTEINASES
Descriptor: ENDOTHIAPEPSIN
Authors:Pearl, L.H, Sewell, B.T, Jenkins, J.A, Cooper, J.B, Blundell, T.L.
Deposit date:1986-06-09
Release date:1986-07-14
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Active Site of Aspartic Proteinases
FEBS Lett., 174, 1984
1LAU
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BU of 1lau by Molmil
URACIL-DNA GLYCOSYLASE
Descriptor: DNA (5'-D(*TP*TP*T)-3'), PROTEIN (URACIL-DNA GLYCOSYLASE (E.C.3.2.2.-))
Authors:Pearl, L.H, Savva, R.
Deposit date:1996-01-03
Release date:1996-06-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structural basis of specific base-excision repair by uracil-DNA glycosylase.
Nature, 373, 1995
1AMW
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BU of 1amw by Molmil
ADP BINDING SITE IN THE HSP90 MOLECULAR CHAPERONE
Descriptor: ADENOSINE-5'-DIPHOSPHATE, HEAT SHOCK PROTEIN 90
Authors:Pearl, L.H, Roe, S.M, Prodromou, C.
Deposit date:1997-06-19
Release date:1998-06-24
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
Cell(Cambridge,Mass.), 90, 1997
1AM1
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BU of 1am1 by Molmil
ATP BINDING SITE IN THE HSP90 MOLECULAR CHAPERONE
Descriptor: ADENOSINE-5'-DIPHOSPHATE, HEAT SHOCK PROTEIN 90
Authors:Pearl, L.H, Roe, S.M, Prodromou, C.
Deposit date:1997-06-20
Release date:1998-06-24
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
Cell(Cambridge,Mass.), 90, 1997
4UUH
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BU of 4uuh by Molmil
X-ray crystal structure of human TNKS in complex with a small molecule inhibitor
Descriptor: 1,2-ETHANEDIOL, 5-methyl-3-[4-(piperazin-1-ylmethyl)phenyl]isoquinolin-1(2H)-one, GLYCEROL, ...
Authors:Oliver, A.W, Rajasekaran, M.B, Pearl, L.H.
Deposit date:2014-07-28
Release date:2015-07-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Design and Discovery of 3-Aryl-5-Substituted-Isoquinolin-1- Ones as Potent and Selective Tankyrase Inhibitors
Medchemcommm, 6, 2015
5MG8
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BU of 5mg8 by Molmil
Crystal structure of the S.pombe Smc5/6 hinge domain
Descriptor: GLYCEROL, SULFATE ION, Structural maintenance of chromosomes protein 5, ...
Authors:Alt, A, Pearl, L.H, Oliver, A.W.
Deposit date:2016-11-21
Release date:2017-02-08
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Specialized interfaces of Smc5/6 control hinge stability and DNA association.
Nat Commun, 8, 2017
8OK2
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BU of 8ok2 by Molmil
Bipartite interaction of TOPBP1 with the GINS complex
Descriptor: DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, DNA replication complex GINS protein PSF3, ...
Authors:Day, M, Oliver, A.W, Pearl, L.H.
Deposit date:2023-03-26
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:TopBP1 utilises a bipartite GINS binding mode to support genome replication.
Nat Commun, 15, 2024
3G65
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BU of 3g65 by Molmil
Crystal Structure of the Human Rad9-Rad1-Hus1 DNA Damage Checkpoint Complex
Descriptor: Cell cycle checkpoint control protein RAD9A, Cell cycle checkpoint protein RAD1, Checkpoint protein HUS1
Authors:Dore, A.S, Kilkenny, M.L, Rzechorzek, N.J, Pearl, L.H.
Deposit date:2009-02-06
Release date:2009-05-26
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the rad9-rad1-hus1 DNA damage checkpoint complex--implications for clamp loading and regulation.
Mol.Cell, 34, 2009
2XNH
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BU of 2xnh by Molmil
Structure and function of the Rad9-binding region of the DNA damage checkpoint adaptor TopBP1
Descriptor: DNA TOPOISOMERASE 2-BINDING PROTEIN 1, IODIDE ION
Authors:Rappas, M, Oliver, A.W, Pearl, L.H.
Deposit date:2010-08-02
Release date:2010-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and Function of the Rad9-Binding Region of the DNA-Damage Checkpoint Adaptor Topbp1.
Nucleic Acids Res., 39, 2011
2XNK
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BU of 2xnk by Molmil
Structure and function of the Rad9-binding region of the DNA damage checkpoint adaptor TopBP1
Descriptor: DNA TOPOISOMERASE 2-BINDING PROTEIN 1, GLYCEROL
Authors:Rappas, M, Oliver, A.W, Pearl, L.H.
Deposit date:2010-08-03
Release date:2010-09-01
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and Function of the Rad9-Binding Region of the DNA-Damage Checkpoint Adaptor Topbp1.
Nucleic Acids Res., 39, 2011
2XX4
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BU of 2xx4 by Molmil
Macrolactone Inhibitor bound to HSP90 N-term
Descriptor: (E)-ETHYL 13-CHLORO-14,16-DIHYDROXY-1,11-DIOXO-1,2,3,4,7,8,9,10,11,12-DECAHYDROBENZO[C][1]AZACYCLOTETRADECINE-10-CARBOXYLATE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82
Authors:Moody, C.J, Prodromou, C, Pearl, L.H, Roe, S.M.
Deposit date:2010-11-08
Release date:2011-11-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies.
Acs Chem.Biol., 6, 2011
7Z6H
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BU of 7z6h by Molmil
Structure of DNA-bound human RAD17-RFC clamp loader and 9-1-1 checkpoint clamp
Descriptor: Cell cycle checkpoint control protein RAD9A, Cell cycle checkpoint protein RAD1,Cell cycle checkpoint protein RAD17, Checkpoint protein HUS1, ...
Authors:Day, M, Oliver, A.W, Pearl, L.H.
Deposit date:2022-03-11
Release date:2022-05-04
Last modified:2022-08-31
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Structure of the human RAD17-RFC clamp loader and 9-1-1 checkpoint clamp bound to a dsDNA-ssDNA junction.
Nucleic Acids Res., 50, 2022
7P0L
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BU of 7p0l by Molmil
Crystal structure of S.pombe Mdb1 BRCT domains in complex with a H2A phosphopeptide
Descriptor: DNA damage response protein Mdb1, Histone H2A-beta
Authors:Day, M, Oliver, A.W, Pearl, L.H.
Deposit date:2021-06-29
Release date:2021-12-01
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1.
DNA Repair (Amst), 108, 2021
7P0J
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BU of 7p0j by Molmil
Crystal structure of S.pombe Mdb1 BRCT domains
Descriptor: CITRIC ACID, DNA damage response protein Mdb1, MAGNESIUM ION, ...
Authors:Day, M, Oliver, A.W, Pearl, L.H.
Deposit date:2021-06-29
Release date:2022-07-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1.
DNA Repair (Amst), 108, 2021
7OA5
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BU of 7oa5 by Molmil
RUVA COMPLEXED TO A HOLLIDAY JUNCTION.
Descriptor: CALCIUM ION, DNA (5'-D(*AP*GP*TP*TP*CP*GP*CP*GP*AP*GP*TP*TP*CP*GP*C)-3'), DNA (5'-D(*AP*GP*TP*TP*CP*GP*CP*GP*CP*GP*CP*GP*AP*AP*CP*T)-3'), ...
Authors:Roe, S.M, Pearl, L.H.
Deposit date:2021-04-19
Release date:2021-04-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.378 Å)
Cite:Crystal structure of an octameric RuvA-Holliday junction complex
Molecular Cell, 2, 1998
5LOH
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BU of 5loh by Molmil
Kinase domain of human Greatwall
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, STAUROSPORINE, ...
Authors:Rajasekaran, M.B, Pearl, L.H, Oliver, A.W.
Deposit date:2016-08-09
Release date:2016-09-07
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct.
Oncotarget, 7, 2016
1W4S
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BU of 1w4s by Molmil
Crystal structure of the proximal BAH domain of polybromo
Descriptor: CHLORIDE ION, POLYBROMO 1 PROTEIN
Authors:Oliver, A.W, Roe, S.M, Pearl, L.H.
Deposit date:2004-07-28
Release date:2005-04-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal Structure of the Proximal Bah Domain of the Polybromo Protein
Biochem.J., 389, 2005

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