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5P21
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REFINED CRYSTAL STRUCTURE OF THE TRIPHOSPHATE CONFORMATION OF H-RAS P21 AT 1.35 ANGSTROMS RESOLUTION: IMPLICATIONS FOR THE MECHANISM OF GTP HYDROLYSIS
Descriptor:C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Pai, E.F., Wittinghofer, A., Kabsch, W.
Deposit date:1990-04-30
Release date:1992-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.
EMBO J., 9, 1990
1GRT
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HUMAN GLUTATHIONE REDUCTASE A34E/R37W MUTANT
Descriptor:GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Stoll, V.S., Simpson, S.J., Krauth-Siegel, R.L., Walsh, C.T., Pai, E.F.
Deposit date:1996-12-17
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry, 36, 1997
2GRT
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HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, OXIDIZED GLUTATHIONE COMPLEX
Descriptor:GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, OXIDIZED GLUTATHIONE DISULFIDE
Authors:Stoll, V.S., Simpson, S.J., Krauth-Siegel, R.L., Walsh, C.T., Pai, E.F.
Deposit date:1997-02-12
Release date:1997-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry, 36, 1997
3GRT
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HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, OXIDIZED TRYPANOTHIONE COMPLEX
Descriptor:GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, 2-AMINO-4-[4-(4-AMINO-4-CARBOXY-BUTYRYLAMINO)-5,8,19,22-TETRAOXO-1,2-DITHIA-6,9,13,18,21-PENTAAZA-CYCLOTETRACOS-23-YLCARBAMOYL]-BUTYRIC ACID
Authors:Stoll, V.S., Simpson, S.J., Krauth-Siegel, R.L., Walsh, C.T., Pai, E.F.
Deposit date:1997-02-12
Release date:1997-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry, 36, 1997
4GRT
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HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, MIXED DISULFIDE BETWEEN TRYPANOTHIONE AND THE ENZYME
Descriptor:GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, BIS(GAMMA-GLUTAMYL-CYSTEINYL-GLYCINYL)SPERMIDINE
Authors:Stoll, V.S., Simpson, S.J., Krauth-Siegel, R.L., Walsh, C.T., Pai, E.F.
Deposit date:1997-02-12
Release date:1997-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry, 36, 1997
5GRT
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HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, GLUTATHIONYLSPERMIDINE COMPLEX
Descriptor:GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONYLSPERMIDINE DISULFIDE
Authors:Stoll, V.S., Simpson, S.J., Krauth-Siegel, R.L., Walsh, C.T., Pai, E.F.
Deposit date:1997-02-12
Release date:1997-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry, 36, 1997
3BDJ
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CRYSTAL STRUCTURE OF BOVINE MILK XANTHINE DEHYDROGENASE WITH A COVALENTLY BOUND OXIPURINOL INHIBITOR
Descriptor:Xanthine dehydrogenase/oxidase, CALCIUM ION, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Eger, B.T., Okamoto, K., Nishino, T., Pai, E.F., Nishino, T.
Deposit date:2007-11-14
Release date:2008-11-25
Last modified:2014-09-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mechanism of inhibition of xanthine oxidoreductase by allopurinol: crystal structure of reduced bovine milk xanthine oxidoreductase bound with oxipurinol.
Nucleosides Nucleotides Nucleic Acids, 27, 2008
821P
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THREE-DIMENSIONAL STRUCTURES AND PROPERTIES OF A TRANSFORMING AND A NONTRANSFORMING GLYCINE-12 MUTANT OF P21H-RAS
Descriptor:C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Scheidig, A.J., Krengel, U., Pai, E.F., Kabsch, W., Wittinghofer, A., Goody, R.S.
Deposit date:1993-03-29
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras.
Biochemistry, 32, 1993
1GNP
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X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP
Descriptor:C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID 3'-O-(N-METHYLANTHRANILOYL-2'-DEOXYGUANYLATE ESTER
Authors:Scheidig, A., Franken, S.M., Corrie, J.E.T., Reid, G.P., Wittinghofer, A., Pai, E.F., Goody, R.S.
Deposit date:1995-05-11
Release date:1995-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp.
J.Mol.Biol., 253, 1995
521P
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THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
Descriptor:H-RAS P21 PROTEIN, MAGNESIUM ION, GUANOSINE-5'-TRIPHOSPHATE
Authors:Schlichting, I., Krengel, U., Kabsch, W., Wittinghofer, A., Pai, E.F.
Deposit date:1991-06-06
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell(Cambridge,Mass.), 62, 1990
1E2A
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ENZYME IIA FROM THE LACTOSE SPECIFIC PTS FROM LACTOCOCCUS LACTIS
Descriptor:ENZYME IIA, MAGNESIUM ION
Authors:Sliz, P., Engelmann, R., Hengstenberg, W., Pai, E.F.
Deposit date:1997-04-25
Release date:1998-04-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of enzyme IIAlactose from Lactococcus lactis reveals a new fold and points to possible interactions of a multicomponent system.
Structure, 5, 1997
1EKJ
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THE X-RAY CRYSTALLOGRAPHIC STRUCTURE OF BETA CARBONIC ANHYDRASE FROM THE C3 DICOT PISUM SATIVUM
Descriptor:BETA-CARBONIC ANHYDRASE, ACETATE ION, AZIDE ION, ...
Authors:Kimber, M.S., Pai, E.F.
Deposit date:2000-03-08
Release date:2000-06-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:The active site architecture of Pisum sativum beta-carbonic anhydrase is a mirror image of that of alpha-carbonic anhydrases.
EMBO J., 19, 2000
1GNQ
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X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP
Descriptor:C-H-RAS P21 PROTEIN, MAGNESIUM ION, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER]
Authors:Scheidig, A., Franken, S.M., Corrie, J.E.T., Reid, G.P., Wittinghofer, A., Pai, E.F., Goody, R.S.
Deposit date:1995-05-11
Release date:1995-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp.
J.Mol.Biol., 253, 1995
1GNR
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X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP
Descriptor:C-H-RAS P21 PROTEIN, MAGNESIUM ION, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER]
Authors:Scheidig, A., Franken, S.M., Corrie, J.E.T., Reid, G.P., Wittinghofer, A., Pai, E.F., Goody, R.S.
Deposit date:1995-05-11
Release date:1995-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp.
J.Mol.Biol., 253, 1995
1NDA
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THE STRUCTURE OF TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE IN THE OXIDIZED AND NADPH REDUCED STATE
Descriptor:TRYPANOTHIONE OXIDOREDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Lantwin, C.B., Kabsch, W., Pai, E.F., Schlichting, I., Krauth-Siegel, R.L.
Deposit date:1993-07-02
Release date:1994-09-30
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The structure of Trypanosoma cruzi trypanothione reductase in the oxidized and NADPH reduced state.
Proteins, 18, 1994
1PLJ
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CRYSTALLOGRAPHIC STUDIES ON P21H-RAS USING SYNCHROTRON LAUE METHOD: IMPROVEMENT OF CRYSTAL QUALITY AND MONITORING OF THE GTPASE REACTION AT DIFFERENT TIME POINTS
Descriptor:C-H-RAS P21 PROTEIN, MAGNESIUM ION, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER]
Authors:Scheidig, A., Sanchez-Llorente, A., Lautwein, A., Pai, E.F., Corrie, J.E.T., Reid, G.P., Wittinghofer, A., Goody, R.S.
Deposit date:1994-03-13
Release date:1994-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystallographic studies on p21(H-ras) using the synchrotron Laue method: improvement of crystal quality and monitoring of the GTPase reaction at different time points.
Acta Crystallogr.,Sect.D, 50, 1994
1PLK
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CRYSTALLOGRAPHIC STUDIES ON P21H-RAS USING SYNCHROTRON LAUE METHOD: IMPROVEMENT OF CRYSTAL QUALITY AND MONITORING OF THE GTPASE REACTION AT DIFFERENT TIME POINTS
Descriptor:C-H-RAS P21 PROTEIN, MAGNESIUM ION, GUANOSINE-5'-TRIPHOSPHATE
Authors:Scheidig, A., Sanchez-Llorente, A., Lautwein, A., Pai, E.F., Corrie, J.E.T., Reid, G.P., Wittinghofer, A., Goody, R.S.
Deposit date:1994-03-13
Release date:1994-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystallographic studies on p21(H-ras) using the synchrotron Laue method: improvement of crystal quality and monitoring of the GTPase reaction at different time points.
Acta Crystallogr.,Sect.D, 50, 1994
1PLL
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CRYSTALLOGRAPHIC STUDIES ON P21H-RAS USING SYNCHROTRON LAUE METHOD: IMPROVEMENT OF CRYSTAL QUALITY AND MONITORING OF THE GTPASE REACTION AT DIFFERENT TIME POINTS
Descriptor:C-H-RAS P21 PROTEIN, GUANOSINE-5'-DIPHOSPHATE
Authors:Scheidig, A., Sanchez-Llorente, A., Lautwein, A., Pai, E.F., Corrie, J.E.T., Reid, G.P., Wittinghofer, A., Goody, R.S.
Deposit date:1994-03-13
Release date:1994-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystallographic studies on p21(H-ras) using the synchrotron Laue method: improvement of crystal quality and monitoring of the GTPase reaction at different time points.
Acta Crystallogr.,Sect.D, 50, 1994
221P
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THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
Descriptor:H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Krengel, U., Scherer, A., Kabsch, W., Wittinghofer, A., Pai, E.F.
Deposit date:1991-06-06
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell(Cambridge,Mass.), 62, 1990
2E2A
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ASP81LEU ENZYME IIA FROM THE LACTOSE SPECIFIC PTS FROM LACTOCOCCUS LACTIS
Descriptor:PROTEIN (ENZYME IIA)
Authors:Sliz, P., Koch, B., Hengstenberg, W., Pai, E.F.
Deposit date:1999-05-14
Release date:2003-06-17
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of Asp81Leu Enzyme Iia from the Lactose Specific Pts from Lactococcus Lactis
To be Published
3N75
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X-RAY CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI INDUCIBLE LYSINE DECARBOXYLASE LDCI
Descriptor:Lysine decarboxylase, inducible, GUANOSINE-5',3'-TETRAPHOSPHATE, ...
Authors:Kanjee, U., Alexopoulos, E., Pai, E.F., Houry, W.A.
Deposit date:2010-05-26
Release date:2011-02-16
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase.
Embo J., 30, 2011
3SEC
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CRYSTAL STRUCTURE OF METHANOTHERMOBACTER THERMAUTOTROPHICUS OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE COMPLEXED WITH PYRAZOFURIN MONOPHOSPHATE
Descriptor:Orotidine 5'-phosphate decarboxylase, GLYCEROL, (1S)-1,4-anhydro-1-(5-carbamoyl-4-hydroxy-1H-pyrazol-3-yl)-5-O-phosphono-D-ribitol
Authors:Liu, Y., Kotra, L.P., Pai, E.F.
Deposit date:2011-06-10
Release date:2012-04-25
Last modified:2012-05-09
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of methanococcus thermolithotrophicus orotidine 5'-monophosphate decarboxylase complexed with pyrazofurin monophosphate
To be Published
421P
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THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
Descriptor:H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Krengel, U., John, J., Scherer, A., Kabsch, W., Wittinghofer, A., Pai, E.F.
Deposit date:1991-06-06
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell(Cambridge,Mass.), 62, 1990
621P
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THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
Descriptor:H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Krengel, U., Scherer, A., Kabsch, W., Wittinghofer, A., Pai, E.F.
Deposit date:1991-06-06
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell(Cambridge,Mass.), 62, 1990
6BTL
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CRYSTAL STRUCTURE OF TRYPANOTHIONE REDUCTASE FROM TRYPANOSOMA BRUCEI IN COMPLEX WITH INHIBITOR RD117 1-[2-(PIPERAZIN-1-YL)ETHYL]-5-{5-[1-(PYRROLIDIN-1-YL)CYCLOHEXYL]-1,3-THIAZOL-2-YL}-1H-INDOLE
Descriptor:Trypanothione reductase, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ...
Authors:Bryson, S., De Gasparo, R., Krauth-Siegel, R.L., Diederich, F., Pai, E.F.
Deposit date:2017-12-06
Release date:2018-06-06
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.797 Å)
Cite:Biological Evaluation and X-ray Co-crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma.
ChemMedChem, 13, 2018