Author results

2ZA0
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CRYSTAL STRUCTURE OF MOUSE GLYOXALASE I COMPLEXED WITH METHYL-GERFELIN
Descriptor:Glyoxalase I, ZINC ION, methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate
Authors:Okumura, H., Kawatani, M., Osada, H.
Deposit date:2007-09-26
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I
Proc.Natl.Acad.Sci.Usa, 105, 2008
2ZHP
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CRYSTAL STRUCTURE OF BLEOMYCIN-BINDING PROTEIN FROM STREPTOALLOTEICHUS HINDUSTANUS COMPLEXED WITH BLEOMYCIN DERIVATIVE
Descriptor:Bleomycin resistance protein, [(2S,3R,4R,5S,6S)-2-[(3R,4R,5R,6R)-2-[(1R,2S)-2-[[6-amino-2-[(1S)-3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[(2S,3R,4R)-5-[[(2R,3S)-1-[2-[4-[4-[3-[4-(3-aminopropylamino)butylamino]propylcarbamoyl]-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-4-methyl-5-oxopentan-2-yl]amino]-1-(3H-imidazol-4-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl] carbamate, COPPER (II) ION, ...
Authors:Okumura, H., Miyazaki, I., Simizu, S., Osada, H.
Deposit date:2008-02-06
Release date:2009-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-Affinity Relationship Study of Bleomycins and Shble protein Using a Chemical Array
To be Published
3ACL
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CRYSTAL STRUCTURE OF HUMAN PIRIN IN COMPLEX WITH TRIPHENYL COMPOUND
Descriptor:Pirin, FE (II) ION, N-{[4-(benzyloxy)phenyl](methyl)-lambda~4~-sulfanylidene}-4-methylbenzenesulfonamide
Authors:Okumura, H., Miyazaki, I., Simizu, S., Osada, H.
Deposit date:2010-01-05
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:A small-molecule inhibitor shows that pirin regulates migration of melanoma cells
Nat.Chem.Biol., 6, 2010
3U0V
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CRYSTAL STRUCTURE ANALYSIS OF HUMAN LYPLAL1
Descriptor:Lysophospholipase-like protein 1
Authors:Burger, M., Zimmermann, T.J., Kondoh, Y., Stege, P., Watanabe, N., Osada, H., Waldmann, H., Vetter, I.R.
Deposit date:2011-09-29
Release date:2011-11-16
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases
J.Lipid Res., 53, 2012
3VNQ
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CO-CRYSTAL STRUCTURE OF NRPS ADENYLATION PROTEIN CYTC1 WITH ATP FROM STREPTOMYCES
Descriptor:NRPS adenylation protein CytC1, ADENOSINE-5'-TRIPHOSPHATE
Authors:Okumura, H., Ueki, M., Shiro, Y., Osada, H.
Deposit date:2012-01-17
Release date:2013-01-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Substrate recognition mechanism of NRPS adenylation protein from Streptomyces
To be Published
3VNR
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CO-CRYSTAL STRUCTURE OF NRPS ADENYLATION PROTEIN CYTC1 WITH AMINOBUTYRIC ACID AND AMP FROM STREPTOMYCES
Descriptor:NRPS adenylation protein CytC1, ADENOSINE MONOPHOSPHATE, ALPHA-AMINOBUTYRIC ACID
Authors:Okumura, H., Ueki, M., Shiro, Y., Osada, H.
Deposit date:2012-01-17
Release date:2013-01-23
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Substrate recognition mechanism of NRPS adenylation protein from Streptomyces
To be Published
3VNS
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CO-CRYSTAL STRUCTURE OF NRPS ADENYLATION PROTEIN CYTC1 WITH D-VALINE AND AMP FROM STREPTOMYCES
Descriptor:NRPS adenylation protein CytC1, ADENOSINE MONOPHOSPHATE, D-VALINE
Authors:Okumura, H., Ueki, M., Shiro, Y., Osada, H.
Deposit date:2012-01-17
Release date:2013-01-23
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Substrate recognition mechanism of NRPS adenylation protein from Streptomyces
to be published
5IH4
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HUMAN CASEIN KINASE 1 ISOFORM DELTA APO (KINASE DOMAIN)
Descriptor:Casein kinase I isoform delta, ZINC ION, S,R MESO-TARTARIC ACID, ...
Authors:Ursu, A., Illich, D.J., Takemoto, Y., Porfetye, A.T., Zhang, M., Brockmeyer, A., Janning, P., Watanabe, N., Osada, H., Vetter, I.R., Ziegler, S., Schoeler, H.R., Waldmann, H.
Deposit date:2016-02-29
Release date:2016-04-13
Last modified:2016-05-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1.
Cell Chem Biol, 23, 2016
5IH5
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HUMAN CASEIN KINASE 1 ISOFORM DELTA (KINASE DOMAIN) IN COMPLEX WITH EPIBLASTIN A
Descriptor:Casein kinase I isoform delta, ZINC ION, 6-(3-chlorophenyl)pteridine-2,4,7-triamine, ...
Authors:Ursu, A., Illich, D.J., Takemoto, Y., Porfetye, A.T., Zhang, M., Brockmeyer, A., Janning, P., Watanabe, N., Osada, H., Vetter, I.R., Ziegler, S., Schoeler, H.R., Waldmann, H.
Deposit date:2016-02-29
Release date:2016-04-13
Last modified:2016-05-04
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1.
Cell Chem Biol, 23, 2016
5IH6
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HUMAN CASEIN KINASE 1 ISOFORM DELTA (KINASE DOMAIN) IN COMPLEX WITH EPIBLASTIN A DERIVATIVE
Descriptor:Casein kinase I isoform delta, ZINC ION, S,R MESO-TARTARIC ACID, ...
Authors:Ursu, A., Illich, D.J., Takemoto, Y., Porfetye, A.T., Zhang, M., Brockmeyer, A., Janning, P., Watanabe, N., Osada, H., Vetter, I.R., Ziegler, S., Schoeler, H.R., Waldmann, H.
Deposit date:2016-02-29
Release date:2016-04-13
Last modified:2016-05-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1.
Cell Chem Biol, 23, 2016
3WVS
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CRYSTAL STRUCTURE OF CYTOCHROME P450REVI
Descriptor:Putative monooxygenase, PROTOPORPHYRIN IX CONTAINING FE, (2E,4S,5S,6E,8E)-10-{(2R,3S,6S,8R,9S)-9-butyl-8-[(1E,3E)-4-carboxy-3-methylbuta-1,3-dien-1-yl]-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl}-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid, ...
Authors:Nagano, S., Takahashi, S., Osada, H., Shiro, Y.
Deposit date:2014-06-06
Release date:2014-10-01
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-Function Analyses of Cytochrome P450revI Involved in Reveromycin A Biosynthesis and Evaluation of the Biological Activity of Its Substrate, Reveromycin T
J.Biol.Chem., 2014
5INF
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STRUCTURAL BASIS FOR ACYL-COA CARBOXYLASE-MEDIATED ASSEMBLY OF UNUSUAL POLYKETIDE SYNTHASE EXTENDER UNITS INCORPORATED INTO THE STAMBOMYCIN ANTIBIOTICS
Descriptor:Carboxyl transferase, HEXANOYL-COENZYME A
Authors:Valentic, T.R., Ray, L., Miyazawa, T., Withall, D.M., Song, L., Osada, H., Tsai, S.C., Challis, G.L.
Deposit date:2016-03-07
Release date:2016-12-28
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.751 Å)
Cite:A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.
Nat Commun, 7, 2016
5ING
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A CROTONYL-COA REDUCTASE-CARBOXYLASE INDEPENDENT PATHWAY FOR ASSEMBLY OF UNUSUAL ALKYLMALONYL-COA POLYKETIDE SYNTHASE EXTENDER UNIT
Descriptor:Putative carboxyl transferase
Authors:Valentic, T.R., Ray, L., Miyazawa, T., Song, L., Withall, D.M., Milligan, J.C., Takahashi, S., Osada, H., Tsai, S.C., Challis, G.L.
Deposit date:2016-03-07
Release date:2016-12-28
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.
Nat Commun, 7, 2016
5INI
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STRUCTURAL BASIS FOR ACYL-COA CARBOXYLASE-MEDIATED ASSEMBLY OF UNUSUAL POLYKETIDE SYNTHASE EXTENDER UNITS INCORPORATED INTO THE STAMBOMYCIN ANTIBIOTICS
Descriptor:Putative carboxyl transferase, HEXANOYL-COENZYME A
Authors:Valentic, T.R., Ray, L., Miyazawa, T., Withall, D.M., Song, L., Milligan, J.C., Osada, H., Tsai, S.C., Challis, G.L.
Deposit date:2016-03-07
Release date:2016-12-28
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.
Nat Commun, 7, 2016