7T5J

Crystal Structure of Strictosidine Synthase in complex with S-IPA (2-(1H-indol-3-yl) propan-1-amine)

Summary for 7T5J

• Entry DOI: 10.2210/pdb7t5j/pdb
• Related: 7L1L 7L1N 7L1O
• Descriptor: Strictosidine synthase, (2S)-2-(1H-indol-3-yl)propan-1-amine (3 entities in total)
• Functional Keywords: alkaloid metabolism, six bladed beta propeller fold, str1, lyase, vacuole, synthase, glycoprotein
• Biological source: Rauvolfia serpentina (serpentwood)
• Total number of polymer chains: 2
• Total formula weight: 70588.86

Authors

Liu, H.,Panjikar, S.,Futamura, Y.,Shao, N.,Osada, H.,Zou, H. (deposition date: 2021-12-12, release date: 2022-12-14, Last modification date: 2023-10-25)

• Primary citation: Liu, H.,Panjikar, S.,Futamura, Y.,Shao, N.,Osada, H.,Zou, H.; beta-Branched Tryptamine Provoked Non Sandwich-Like-Mode Catalysis of Strictosidine Synthase to Antimalarial Indole Alkaloids; to be published,

Experimental method

X-RAY DIFFRACTION (2.86 Å)