4V1D
Ternary complex among two human derived single chain antibody fragments and Cn2 toxin from scorpion Centruroides noxius.
Summary for 4V1D
Entry DOI | 10.2210/pdb4v1d/pdb |
Descriptor | SINGLE CHAIN ANTIBODY FRAGMENT LR, HEAVY CHAIN, SINGLE CHAIN ANTIBODY FRAGMENT LR, LIGHT CHAIN, BETA-MAMMAL TOXIN CN2, ... (6 entities in total) |
Functional Keywords | toxin-immune system complex, human scfv, scorpion venom neutralization, directed evolution, cn2 toxin., toxin/immune system |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Secreted: 4V1D |
Total number of polymer chains | 5 |
Total formula weight | 64315.96 |
Authors | Riano-Umbarila, L.,Serrano-Posada, H.,Rojas-Trejo, S.,Rudino-Pinera, E.,Becerril, B. (deposition date: 2014-09-25, release date: 2015-10-07, Last modification date: 2024-01-10) |
Primary citation | Riano-Umbarila, L.,Ledezma-Candanoza, L.M.,Serrano-Posada, H.,Fernandez-Taboada, G.,Olamendi-Portugal, T.,Rojas-Trejo, S.,Gomez-Ramirez, I.V.,Rudino-Pinera, E.,Possani, L.D.,Becerril, B. Optimal Neutralization of Centruroides Noxius Venom is Understood Through a Structural Complex between Two Antibody Fragments and the Cn2 Toxin. J.Biol.Chem., 291:1619-, 2016 Cited by PubMed: 26589800DOI: 10.1074/JBC.M115.685297 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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