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3SAD
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BU of 3sad by Molmil
Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-mehtylphenyl)-2,4-dioxobutanoic acid inhibitor
Descriptor: 4-(2-methylphenyl)-2,4-dioxobutanoic acid, MAGNESIUM ION, Malate synthase G
Authors:Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2011-06-02
Release date:2012-11-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase.
Chem.Biol., 19, 2012
2A11
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BU of 2a11 by Molmil
Crystal Structure of Nuclease Domain of Ribonuclase III from Mycobacterium Tuberculosis
Descriptor: CALCIUM ION, Ribonuclease III
Authors:Akey, D.L, Berger, J.M, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2005-06-17
Release date:2005-07-05
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the nuclease domain of ribonuclease III from M. tuberculosis at 2.1 A
Protein Sci., 14, 2005
2A2J
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BU of 2a2j by Molmil
Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis
Descriptor: Pyridoxamine 5'-phosphate oxidase
Authors:Pedelacq, J.-D, Rho, B.-S, Kim, C.-Y, Waldo, G.S, Lekin, T.P, Segelke, B.W, Rupp, B, Hung, L.-W, Kim, S.-I, Terwilliger, T.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2005-06-22
Release date:2005-08-23
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis.
Proteins, 62, 2005
3LAJ
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BU of 3laj by Molmil
The Structure of the Intermediate Complex of the Arginine Repressor from Mycobacterium tuberculosis Bound to its DNA Operator and L-arginine.
Descriptor: 5'-D(*TP*TP*GP*CP*AP*TP*AP*AP*CP*GP*AP*TP*GP*CP*AP*A)-3', 5'-D(*TP*TP*GP*CP*AP*TP*CP*GP*TP*TP*AP*TP*GP*CP*AP*A)-3', ARGININE, ...
Authors:Cherney, L.T, Cherney, M.M, Garen, C.R, James, M.N.G, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2010-01-06
Release date:2010-05-05
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.306 Å)
Cite:crystal structure of the intermediate complex of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator reveals detailed mechanism of arginine repression.
J.Mol.Biol., 399, 2010
3KGF
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BU of 3kgf by Molmil
The structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis complexed with phenylalanine and tryptophan
Descriptor: CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ...
Authors:Parker, E.J, Jameson, G.B, Jiao, W, Webby, C.J, Baker, E.N, Baker, H.M, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2009-10-29
Release date:2010-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis
J.Biol.Chem., 285, 2010
5CYY
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BU of 5cyy by Molmil
Structure of the C-terminal domains of DipZ from Mycobacterium tuberculosis
Descriptor: Protein DipZ
Authors:Goldstone, D.C, Metcalf, P, Baker, E.N, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2015-07-31
Release date:2016-01-13
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the ectodomain of the electron transporter Rv2874 from Mycobacterium tuberculosis reveals a thioredoxin-like domain combined with a carbohydrate-binding module.
Acta Crystallogr D Struct Biol, 72, 2016
6DNP
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BU of 6dnp by Molmil
Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-F-3-Methyl-6-F-phenyldiketoacid
Descriptor: (2Z)-4-(2,6-difluoro-3-methylphenyl)-2-hydroxy-4-oxobut-2-enoic acid, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, ...
Authors:Krieger, I.V, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC), Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2018-06-07
Release date:2018-09-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.711 Å)
Cite:Anion-pi Interactions in Computer-Aided Drug Design: Modeling the Inhibition of Malate Synthase by Phenyl-Diketo Acids.
J Chem Inf Model, 58, 2018
4JAP
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BU of 4jap by Molmil
Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones
Descriptor: (2S)-2-methyl-3-oxooctadecanoic acid, Alpha-pyrone synthesis polyketide synthase-like Pks11, COENZYME A, ...
Authors:Gokulan, K, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2013-02-19
Release date:2013-04-24
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (1.833 Å)
Cite:Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones.
J.Biol.Chem., 288, 2013
4JAR
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BU of 4jar by Molmil
Crystal structure of mycobacterium tuberculosis pks11 in complex with polyketide intermediates and evidence that it synthesize ALKYLPYRONES
Descriptor: Alpha-pyrone synthesis polyketide synthase-like Pks11
Authors:Gokulan, K, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2013-02-19
Release date:2013-04-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones.
J.Biol.Chem., 288, 2013
4JAO
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BU of 4jao by Molmil
Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones
Descriptor: (2S)-2-methylheptadecan-1-ol, Alpha-pyrone synthesis polyketide synthase-like Pks11, PALMITIC ACID
Authors:Gokulan, K, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2013-02-18
Release date:2013-04-24
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones.
J.Biol.Chem., 288, 2013
4JAQ
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BU of 4jaq by Molmil
Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones
Descriptor: 3,5-dioxoicosanoic acid, Alpha-pyrone synthesis polyketide synthase-like Pks11, COENZYME A, ...
Authors:Gokulan, K, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2013-02-19
Release date:2013-04-24
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones.
J.Biol.Chem., 288, 2013
4JD3
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BU of 4jd3 by Molmil
Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones
Descriptor: Alpha-pyrone synthesis polyketide synthase-like Pks11, COENZYME A, PALMITIC ACID
Authors:Gokulan, K, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2013-02-22
Release date:2013-04-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones.
J.Biol.Chem., 288, 2013
4JAT
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BU of 4jat by Molmil
Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones
Descriptor: Alpha-pyrone synthesis polyketide synthase-like Pks11, PALMITIC ACID
Authors:Gokulan, K, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2013-02-19
Release date:2013-04-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones.
J.Biol.Chem., 288, 2013
3SB0
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BU of 3sb0 by Molmil
Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-chloro-6-fluoro-3-methylphenyl)-2,4-dioxobutanoic acid inhibitor
Descriptor: 4-(2-chloro-6-fluoro-3-methylphenyl)-2,4-dioxobutanoic acid, MAGNESIUM ION, Malate synthase G
Authors:Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2011-06-03
Release date:2012-11-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase.
Chem.Biol., 19, 2012
3S9I
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BU of 3s9i by Molmil
Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-4-dioxo-4-phenylbutanoic acid inhibitor
Descriptor: 2-4-DIOXO-4-PHENYLBUTANOIC ACID, MAGNESIUM ION, Malate synthase G
Authors:Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2011-06-01
Release date:2012-11-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase.
Chem.Biol., 19, 2012
3NE3
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BU of 3ne3 by Molmil
Mycobacterium tuberculosis Acyl Carrier Protein Synthase Apo structure
Descriptor: Holo-[acyl-carrier-protein] synthase
Authors:Gokulan, K, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2010-06-08
Release date:2010-07-28
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations.
Acta Crystallogr.,Sect.D, 67, 2011
3S9Z
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BU of 3s9z by Molmil
Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-bromophenyl)-2,4-dioxobutanoic acid inhibitor
Descriptor: 4-(2-bromophenyl)-2,4-dioxobutanoic acid, MAGNESIUM ION, Malate synthase G
Authors:Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2011-06-02
Release date:2012-11-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.793 Å)
Cite:Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase.
Chem.Biol., 19, 2012
3SAZ
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BU of 3saz by Molmil
Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(3-bromophenyl)-2,4-dioxobutanoic acid inhibitor
Descriptor: 4-(3-bromophenyl)-2,4-dioxobutanoic acid, MAGNESIUM ION, Malate synthase G
Authors:Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2011-06-03
Release date:2012-11-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase.
Chem.Biol., 19, 2012
3NE9
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BU of 3ne9 by Molmil
Chronobacterium ammoiniagenes apo-ACPS structure
Descriptor: Phosphopantetheine protein transferase, Ppt1p, SULFATE ION
Authors:Gokulan, K, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2010-06-08
Release date:2010-08-25
Last modified:2020-09-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations.
Acta Crystallogr.,Sect.D, 67, 2011
2O2J
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BU of 2o2j by Molmil
Mycobacterium tuberculosis tryptophan synthase beta chain dimer (apoform)
Descriptor: Tryptophan synthase beta chain
Authors:Burenkov, G.P, Kachalova, G.S, Bartunik, H.D, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2006-11-29
Release date:2008-04-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Structure Tryptophan SYNTHASE beta chain dimer from MYCOBACTERIUM Tuberculosis
To be Published
2O2E
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BU of 2o2e by Molmil
Mycobacterium tuberculosis tryptophan synthase beta subunit dimer (apoform)
Descriptor: Tryptophan synthase beta chain
Authors:Burenkov, G.P, Kachalova, G.S, Bartunik, H.D, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2006-11-29
Release date:2008-04-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure Tryptophan SYNTHASE beta subunit dimer from MYCOBACTERIUM TUBERCULOSIS
To be Published
2B7O
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BU of 2b7o by Molmil
The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase from Mycobacterium tuberculosis
Descriptor: 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG, MANGANESE (II) ION, O-DODECANYL OCTAETHYLENE GLYCOL, ...
Authors:Webby, C.J, Baker, H.M, Lott, J.S, Baker, E.N, Parker, E.J, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2005-10-05
Release date:2005-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes
J.Mol.Biol., 354, 2005
2O15
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BU of 2o15 by Molmil
Mycobacterium tuberculosis epsp synthase after partial products withdrawal
Descriptor: 3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE, PHOSPHATE ION, SULFATE ION
Authors:Kachalova, G.S, Bartunik, H.D, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2006-11-28
Release date:2008-04-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Complexes of 3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE
To be Published
2O0X
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BU of 2o0x by Molmil
Mycobacterium tuberculosis epsp synthase in complex with intermediate
Descriptor: 3-phosphoshikimate 1-carboxyvinyltransferase, 5-(1-CARBOXY-1-PHOSPHONOOXY-ETHOXYL)-4-HYDROXY-3-PHOSPHONOOXY-CYCLOHEX-1-ENECARBOXYLIC ACID, SULFATE ION
Authors:Kachalova, G.S, Bartunik, H.D, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2006-11-28
Release date:2008-04-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Complexes of 3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE
To be Published
2O0Z
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BU of 2o0z by Molmil
Mycobacterium tuberculosis epsp synthase in complex with product (EPS)
Descriptor: 3-phosphoshikimate 1-carboxyvinyltransferase, 5-[(1-CARBOXYVINYL)OXY]-4-HYDROXY-3-(PHOSPHONOOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID, PHOSPHATE ION, ...
Authors:Kachalova, G.S, Bartunik, H.D, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2006-11-28
Release date:2008-04-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Complexes of 3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE
To be Published

 

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