4WXH
| Carminomycin-4-O-methyltransferase (DnrK) variant (298Ser insert) in complex with S-adenosyl-L-homocysteine (SAH) and aclacinomycin T | Descriptor: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, Carminomycin 4-O-methyltransferase DnrK, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Metsa-Ketela, M, Niiranen, L. | Deposit date: | 2014-11-13 | Release date: | 2015-07-29 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis. Proc.Natl.Acad.Sci.USA, 112, 2015
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4X4J
| Structural and Functional Studies of BexE: Insights into Oxidation During BE-7585A Biosynthesis | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Putative oxygenase, SULFATE ION | Authors: | Tsai, S.-C, Jackson, D.R, Patel, A, Barajas, J.F, Rohr, J, Yu, X, Liu, H.-W, Sasaki, E, Calveras, J, Metsa-Ketela, M. | Deposit date: | 2014-12-02 | Release date: | 2015-12-02 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural and Functional Studies of BexE: Insights into Oxidation During BE-7585A Biosynthesis To Be Published
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4OSP
| The crystal structure of urdamycin C-6 ketoreductase domain UrdMred with bound NADP and rabelomycin | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxygenase-reductase, rabelomycin | Authors: | Niiranen, L, Paananen, P, Patrikainen, P, Metsa-Ketela, M. | Deposit date: | 2014-02-13 | Release date: | 2014-10-01 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure-based engineering of angucyclinone 6-ketoreductases. Chem.Biol., 21, 2014
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4OSO
| The crystal structure of landomycin C-6 ketoreductase LanV with bound NADP and rabelomycin | Descriptor: | DI(HYDROXYETHYL)ETHER, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Reductase homolog, ... | Authors: | Paananen, P, Niiranen, L, Patrikainen, P, Metsa-Ketela, M. | Deposit date: | 2014-02-13 | Release date: | 2014-10-01 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure-based engineering of angucyclinone 6-ketoreductases. Chem.Biol., 21, 2014
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2QA1
| Crystal structure of PgaE, an aromatic hydroxylase involved in angucycline biosynthesis | Descriptor: | 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Koskiniemi, H, Dobritzsch, D, Metsa-Ketela, M, Kallio, P, Niemi, J, Schneider, G. | Deposit date: | 2007-06-14 | Release date: | 2007-08-14 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis J.Mol.Biol., 372, 2007
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2QA2
| Crystal structure of CabE, an aromatic hydroxylase from angucycline biosynthesis, determined to 2.7 A resolution | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Polyketide oxygenase CabE | Authors: | Koskiniemi, H, Dobritzsch, D, Metsa-Ketela, M, Kallio, P, Niemi, J, Schneider, G. | Deposit date: | 2007-06-14 | Release date: | 2007-08-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis J.Mol.Biol., 372, 2007
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4AN4
| Crystal structure of the glycosyltransferase SnogD from Streptomyces nogalater | Descriptor: | DEOXYURIDINE-5'-DIPHOSPHATE, GLYCOSYL TRANSFERASE | Authors: | Claesson, M, Siitonen, V, Dobritzsch, D, Metsa-Ketela, M, Schneider, G. | Deposit date: | 2012-03-15 | Release date: | 2012-09-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal Structure of the Glycosyltransferase Snogd from the Biosynthetic Pathway of the Nogalamycin in Streptomyces Nogalater. FEBS J., 279, 2012
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4AMB
| Crystal structure of the glycosyltransferase SnogD from Streptomyces nogalater | Descriptor: | DEOXYURIDINE-5'-DIPHOSPHATE, SNOGD | Authors: | Claesson, M, Siitonen, V, Dobritzsch, D, Metsa-Ketela, M, Schneider, G. | Deposit date: | 2012-03-08 | Release date: | 2012-09-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | Crystal Structure of the Glycosyltransferase Snogd from the Biosynthetic Pathway of the Nogalamycin in Streptomyces Nogalater. FEBS J., 279, 2012
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4AMG
| Crystal structure of the glycosyltransferase SnogD from Streptomyces nogalater | Descriptor: | SNOGD | Authors: | Claesson, M, Siitonen, V, Dobritzsch, D, Metsa-Ketela, M, Schneider, G. | Deposit date: | 2012-03-09 | Release date: | 2012-09-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Crystal Structure of the Glycosyltransferase Snogd from the Biosynthetic Pathway of the Nogalamycin in Streptomyces Nogalater. FEBS J., 279, 2012
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4KWH
| The crystal structure of angucycline C-6 ketoreductase LanV with bound NADP | Descriptor: | ACETIC ACID, DI(HYDROXYETHYL)ETHER, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Paananen, P, Patrikainen, P, Kallio, P, Mantsala, P, Niemi, J, Niiranen, L, Metsa-Ketela, M. | Deposit date: | 2013-05-24 | Release date: | 2013-07-31 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis. Biochemistry, 52, 2013
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4ICY
| Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Kallio, P, Patrikainen, P, Belogurov, G, Mantsala, P, Yang, K, Niemi, J, Metsa-Ketela, M. | Deposit date: | 2012-12-11 | Release date: | 2013-06-12 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE. Biochemistry, 52, 2013
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4KWI
| The crystal structure of angucycline C-6 ketoreductase LanV with bound NADP and 11-deoxy-6-oxylandomycinone | Descriptor: | 1,8-dihydroxy-3-methyltetraphene-6,7,12(5H)-trione, DI(HYDROXYETHYL)ETHER, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Paananen, P, Patrikainen, P, Mantsala, P, Niemi, J, Niiranen, L, Metsa-Ketela, M. | Deposit date: | 2013-05-24 | Release date: | 2013-07-31 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis. Biochemistry, 52, 2013
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4EX6
| Crystal structure of the alnumycin P phosphatase AlnB | Descriptor: | AlnB, BORIC ACID, MAGNESIUM ION | Authors: | Oja, T, Niiranen, L, Sandalova, T, Klika, K.D, Niemi, J, Mantsala, P, Schneider, G, Metsa-Ketela, M. | Deposit date: | 2012-04-30 | Release date: | 2013-01-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway. Proc.Natl.Acad.Sci.USA, 110, 2013
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4EX9
| Crystal structure of the prealnumycin C-glycosynthase AlnA in complex with ribulose 5-phosphate | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AlnA, CALCIUM ION, ... | Authors: | Oja, T, Niiranen, L, Sandalova, T, Klika, K.D, Niemi, J, Mantsala, P, Schneider, G, Metsa-Ketela, M. | Deposit date: | 2012-04-30 | Release date: | 2013-01-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway. Proc.Natl.Acad.Sci.USA, 110, 2013
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5EQU
| Crystal structure of the epimerase SnoN in complex with Fe3+, alpha ketoglutarate and nogalamycin RO | Descriptor: | 2-OXOGLUTARIC ACID, FE (III) ION, Nogalamycin RO, ... | Authors: | Selvaraj, B, Lindqvist, Y, Siitonen, V, Metsa-Ketela, M, Schneider, G. | Deposit date: | 2015-11-13 | Release date: | 2016-05-11 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway. Proc.Natl.Acad.Sci.USA, 113, 2016
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5EP9
| Crystal structure of the non-heme alpha ketoglutarate dependent epimerase SnoN from nogalamycin biosynthesis | Descriptor: | 2-OXOGLUTARIC ACID, ACETATE ION, FE (III) ION, ... | Authors: | Selvaraj, B, Lindqvist, Y, Niiranen, L, Siitonen, V, Metsa-Ketela, M, Schneider, G. | Deposit date: | 2015-11-11 | Release date: | 2016-05-11 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway. Proc.Natl.Acad.Sci.USA, 113, 2016
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5EPA
| Crystal structure of non-heme alpha ketoglutarate dependent carbocyclase SnoK from nogalamycin biosynthesis | Descriptor: | 2-OXOGLUTARIC ACID, FE (III) ION, MAGNESIUM ION, ... | Authors: | Selvaraj, B, Lindqvist, Y, Siitonen, V, Niiranen, L, Metsa-Ketela, M, Schneider, G. | Deposit date: | 2015-11-11 | Release date: | 2016-05-11 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway. Proc.Natl.Acad.Sci.USA, 113, 2016
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5ERL
| Crystal structure of the epimerase SnoN in complex with Ni2+, succinate and nogalamycin RO | Descriptor: | NICKEL (II) ION, Nogalamycin RO, SUCCINIC ACID, ... | Authors: | Selvaraj, B, Lindqvist, Y, Siitonen, V, Metsa-Ketela, M, Schneider, G. | Deposit date: | 2015-11-14 | Release date: | 2016-05-11 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway. Proc.Natl.Acad.Sci.USA, 113, 2016
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4EX7
| Crystal structure of the alnumycin P phosphatase in complex with free phosphate | Descriptor: | AlnB, BORIC ACID, MAGNESIUM ION, ... | Authors: | Oja, T, Niiranen, L, Sandalova, T, Klika, K.D, Niemi, J, Mantsala, P, Schneider, G, Metsa-Ketela, M. | Deposit date: | 2012-04-30 | Release date: | 2013-01-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway. Proc.Natl.Acad.Sci.USA, 110, 2013
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4EX8
| Crystal structure of the prealnumycin C-glycosynthase AlnA | Descriptor: | AlnA, CALCIUM ION, CHLORIDE ION, ... | Authors: | Oja, T, Niiranen, L, Sandalova, T, Klika, K.D, Niemi, J, Mantsala, P, Schneider, G, Metsa-Ketela, M. | Deposit date: | 2012-04-30 | Release date: | 2013-01-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway. Proc.Natl.Acad.Sci.USA, 110, 2013
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6P77
| 2.5 Angstrom structure of Caci_6494 from Catenulispora Acidiphila | Descriptor: | Aromatic-ring-hydroxylating dioxygenase beta subunit, GLYCEROL, TETRAETHYLENE GLYCOL, ... | Authors: | Vuksanovic, N, Silvaggi, N.R. | Deposit date: | 2019-06-05 | Release date: | 2020-06-17 | Last modified: | 2020-09-02 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Structural characterization of three noncanonical NTF2-like superfamily proteins: implications for polyketide biosynthesis. Acta Crystallogr.,Sect.F, 76, 2020
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6P7L
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7OWB
| Chimeric carminomycin-4-O-methyltransferase (DnrK) with a region from 10-hydroxylase CalMB | Descriptor: | Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein, S-ADENOSYL-L-HOMOCYSTEINE, methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate | Authors: | Dinis, P, MetsaKetela, M. | Deposit date: | 2021-06-17 | Release date: | 2022-07-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Evolution-inspired engineering of anthracycline methyltransferases. Pnas Nexus, 2, 2023
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7OY1
| DnrK mutant RTCR | Descriptor: | Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein,Aclacinomycin 10-hydroxylase RdmB, S-ADENOSYL-L-HOMOCYSTEINE, methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate | Authors: | Dinis, P, MetsaKetela, M. | Deposit date: | 2021-06-23 | Release date: | 2022-07-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Evolution-inspired engineering of anthracycline methyltransferases. Pnas Nexus, 2, 2023
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5BKA
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