4ICY

Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE

Summary for 4ICY

Entry DOI	10.2210/pdb4icy/pdb
Related	2QA1
Descriptor	Polyketide oxygenase PgaE, FLAVIN-ADENINE DINUCLEOTIDE, 1,2-ETHANEDIOL, ... (7 entities in total)
Functional Keywords	fad-dependent aromatic hydroxylation, monooxygenase, fad, oxidoreductase
Biological source	Streptomyces sp. PGA64
Total number of polymer chains	1
Total formula weight	55104.60
Authors	Kallio, P.,Patrikainen, P.,Belogurov, G.,Mantsala, P.,Yang, K.,Niemi, J.,Metsa-Ketela, M. (deposition date: 2012-12-11, release date: 2013-06-12, Last modification date: 2024-04-03)
Primary citation	Kallio, P.,Patrikainen, P.,Belogurov, G.A.,Mantsala, P.,Yang, K.,Niemi, J.,Metsa-Ketela, M. Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE. Biochemistry, 52:4507-4516, 2013 Cited by PubMed: 23731237 DOI: 10.1021/bi400381s PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation