4ICY
Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Polyketide oxygenase PgaE | polymer | 500 | 53623.6 | 1 | UniProt (Q93LY7) Pfam (PF01494) Pfam (PF21274) In PDB | Streptomyces sp. PGA64 | |
2 | A | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 1 | Chemie (FAD) | |||
3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
5 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
6 | A | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
7 | water | water | 18.0 | 113 | Chemie (HOH) |
Sequence modifications
A: 2 - 491 (UniProt: Q93LY7)
PDB | External Database | Details |
---|---|---|
Ala -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
Arg 0 | - | expression tag |
Ser 1 | - | expression tag |
Gln 78 | Pro 78 | engineered mutation |
Phe 79 | Ile 79 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 53623.6 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 1481.0 | |
All* | Total formula weight | 55104.6 |