5D2N
 
 | Crystal structure of C25-NLV-HLA-A2 complex | Descriptor: | ASN-LEU-VAL-PRO-MET-VAL-ALA-THR-VAL, Beta-2-microglobulin, C25 alpha, ... | Authors: | Mariuzza, R.A, Yang, X. | Deposit date: | 2015-08-05 | Release date: | 2015-10-07 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | Structural Basis for Clonal Diversity of the Public T Cell Response to a Dominant Human Cytomegalovirus Epitope. J.Biol.Chem., 290, 2015
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1NDG
 
 | Crystal structure of Fab fragment of antibody HyHEL-8 complexed with its antigen lysozyme | Descriptor: | ACETIC ACID, Lysozyme C, antibody kappa light chain, ... | Authors: | Mariuzza, R.A, Li, Y, Li, H, Yang, F, Smith-Gill, S.J. | Deposit date: | 2002-12-09 | Release date: | 2003-06-03 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | X-ray snapshots of the maturation of an antibody response to a protein antigen Nat.Struct.Biol., 10, 2003
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1NBY
 
 | Crystal Structure of HyHEL-63 complexed with HEL mutant K96A | Descriptor: | Lysozyme C, antibody kappa light chain, immunoglobulin gamma 1 chain | Authors: | Mariuzza, R.A, Li, Y, Urrutia, M, Smith-Gill, S.J. | Deposit date: | 2002-12-04 | Release date: | 2003-04-01 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Dissection of binding interactions in the complex between the anti-lysozyme antibody HyHEL-63 and its antigen Biochemistry, 42, 2003
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1NBZ
 
 | Crystal Structure of HyHEL-63 complexed with HEL mutant K97A | Descriptor: | Lysozyme C, antibody kappa light chain, immunoglobulin gamma 1 chain | Authors: | Mariuzza, R.A, Li, Y, Urrutia, M, Smith-Gill, S.J. | Deposit date: | 2002-12-04 | Release date: | 2003-04-01 | Last modified: | 2024-11-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Dissection of binding interactions in the complex between the anti-lysozyme antibody HyHEL-63 and its antigen Biochemistry, 42, 2003
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1NDM
 
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1KIP
 
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1KIQ
 
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1TVD
 
 | VARIABLE DOMAIN OF T CELL RECEPTOR DELTA CHAIN | Descriptor: | T CELL RECEPTOR | Authors: | Li, H.M, Lebedeva, M.I, Llera, A.S, Fields, B.A, Brenner, M.B, Mariuzza, R.A. | Deposit date: | 1997-10-19 | Release date: | 1998-04-22 | Last modified: | 2024-11-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of the Vdelta domain of a human gammadelta T-cell antigen receptor. Nature, 391, 1998
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5D2L
 
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7RD2
 
 | Co-crystal structure of Chaetomium glucosidase with compound 2 | Descriptor: | (2R,3R,4R,5S)-1-{[4-({4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-nitroanilino}methyl)phenyl]methyl}-2-(hydroxymethyl)piperidine-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chaetomium alpha glucosidase, ... | Authors: | Karade, S.S, Mariuzza, R.A. | Deposit date: | 2021-07-09 | Release date: | 2023-02-22 | Last modified: | 2024-11-06 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Structure-Based Design of Potent Iminosugar Inhibitors of Endoplasmic Reticulum alpha-Glucosidase I with Anti-SARS-CoV-2 Activity. J.Med.Chem., 66, 2023
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1AC6
 
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1A2Y
 
 | HEN EGG WHITE LYSOZYME, D18A MUTANT, IN COMPLEX WITH MOUSE MONOCLONAL ANTIBODY D1.3 | Descriptor: | IGG1-KAPPA D1.3 FV (HEAVY CHAIN), IGG1-KAPPA D1.3 FV (LIGHT CHAIN), LYSOZYME, ... | Authors: | Tsuchiya, D, Mariuzza, R.A. | Deposit date: | 1998-01-13 | Release date: | 1998-04-29 | Last modified: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | A mutational analysis of binding interactions in an antigen-antibody protein-protein complex. Biochemistry, 37, 1998
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1TWQ
 
 | Crystal structure of the C-terminal PGN-binding domain of human PGRP-Ialpha in complex with PGN analog muramyl tripeptide | Descriptor: | N-acetyl-beta-muramic acid, NICKEL (II) ION, muramyl tripeptide, ... | Authors: | Guan, R, Roychowdury, A, Boons, G.-A, Mariuzza, R.A. | Deposit date: | 2004-07-01 | Release date: | 2004-12-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for peptidoglycan binding by peptidoglycan recognition proteins Proc.Natl.Acad.Sci.USA, 101, 2004
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7JTY
 
 | Co-crystal structure of alpha glucosidase with compound 1 | Descriptor: | (1S,2S,3R,4S,5S)-5-(butylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol, 1,2-ETHANEDIOL, Alpha glucosidase 2 alpha neutral subunit, ... | Authors: | Karade, S.S, Mariuzza, R.A. | Deposit date: | 2020-08-18 | Release date: | 2021-10-13 | Last modified: | 2024-10-23 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum alpha-Glucosidases I and II with Antiviral Activity. J.Med.Chem., 64, 2021
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7RM4
 
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2IAM
 
 | Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR | Descriptor: | 15-mer peptide from Triosephosphate isomerase, CD4+ T cell receptor E8 alpha chain, CD4+ T cell receptor E8 beta chain, ... | Authors: | Deng, L, Langley, R.J, Mariuzza, R.A. | Deposit date: | 2006-09-08 | Release date: | 2007-04-03 | Last modified: | 2024-11-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor Nat.Immunol., 8, 2007
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2IAN
 
 | Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR | Descriptor: | 15-mer peptide from Triosephosphate isomerase, CD4+ T cell receptor E8 alpha chain, CD4+ T cell receptor E8 beta chain, ... | Authors: | Deng, L, Langley, R.J, Mariuzza, R.A. | Deposit date: | 2006-09-08 | Release date: | 2007-04-03 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor Nat.Immunol., 8, 2007
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8YJ3
 
 | N17.1.2 recognition of NRAS neoantigens | Descriptor: | tcr alpha, tcr beta | Authors: | Wu, D.C, Mariuzza, R.A. | Deposit date: | 2024-02-29 | Release date: | 2024-12-04 | Method: | X-RAY DIFFRACTION (3.503 Å) | Cite: | Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens. Sci Adv, 10, 2024
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8YJ2
 
 | N17.1.2 recognition of NRAS neoantigens | Descriptor: | Beta-2-microglobulin, ILE-LEU-ASP-THR-ALA-GLY-ARG-GLU-GLU-TYR, human leukocyte antigen, ... | Authors: | Wu, D.C, Mariuzza, R.A. | Deposit date: | 2024-02-29 | Release date: | 2024-12-04 | Method: | X-RAY DIFFRACTION (2.261 Å) | Cite: | Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens. Sci Adv, 10, 2024
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8YIV
 
 | N17.1.2 recognition of NRAS neoantigens | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ... | Authors: | Wu, D.C, Mariuzza, R.A. | Deposit date: | 2024-02-29 | Release date: | 2024-12-04 | Method: | X-RAY DIFFRACTION (2.101 Å) | Cite: | Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens. Sci Adv, 10, 2024
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1KTK
 
 | Complex of Streptococcal pyrogenic enterotoxin C (SpeC) with a human T cell receptor beta chain (Vbeta2.1) | Descriptor: | Exotoxin type C, T-cell receptor beta chain | Authors: | Sundberg, E.J, Li, H, Llera, A.S, McCormick, J.K, Tormo, J, Karjalainen, K, Schlievert, P.M, Mariuzza, R.A. | Deposit date: | 2002-01-16 | Release date: | 2002-06-07 | Last modified: | 2024-11-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes. Structure, 10, 2002
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1L0Y
 
 | T cell receptor beta chain complexed with superantigen SpeA soaked with zinc | Descriptor: | 14.3.d T cell receptor beta chain, Exotoxin type A, GLYCEROL, ... | Authors: | Li, H, Sundberg, E.J, Mariuzza, R.A. | Deposit date: | 2002-02-14 | Release date: | 2002-04-03 | Last modified: | 2024-11-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes. Structure, 10, 2002
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3T0E
 
 | Crystal structure of a complete ternary complex of T cell receptor, peptide-MHC and CD4 | Descriptor: | HLA class II histocompatibility antigen, DR alpha chain, DRB1-4 beta chain, ... | Authors: | Yin, Y, Mariuzza, R.A. | Deposit date: | 2011-07-20 | Release date: | 2012-03-07 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4. Proc.Natl.Acad.Sci.USA, 109, 2012
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8TXQ
 
 | CryoEM structure of non-neutralizing antibody CBH-4B in complex with Hepatitis C virus envelope glycoprotein E2 | Descriptor: | CBH-4B Heavy chain, CBH-4B Light chain, envelope glycoprotein E2 | Authors: | Shahid, S, Liqun, J, Liu, Y, Hasan, S.S, Mariuzza, R.A. | Deposit date: | 2023-08-24 | Release date: | 2024-08-28 | Last modified: | 2025-07-09 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers. Commun Biol, 8, 2025
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8TZY
 
 | CryoEM structure of non-neutralizing bivalent antibody CBH-4B in complex with Hepatitis C virus envelope glycoprotein E2 | Descriptor: | CBH4B Heavy chain, CBH4B Light chain, envelope glycoprotein E2 | Authors: | Shahid, S, Liqun, J, Liu, Y, Hasan, S.S, Mariuzza, R.A. | Deposit date: | 2023-08-28 | Release date: | 2024-09-04 | Last modified: | 2025-07-09 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers. Commun Biol, 8, 2025
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