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1FNF
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BU of 1fnf by Molmil
FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10
Descriptor: FIBRONECTIN
Authors:Leahy, D.J, Aukhil, I, Erickson, H.P.
Deposit date:1995-09-30
Release date:1996-01-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region.
Cell(Cambridge,Mass.), 84, 1996
1CD8
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BU of 1cd8 by Molmil
CRYSTAL STRUCTURE OF A SOLUBLE FORM OF THE HUMAN T CELL CO-RECEPTOR CD8 AT 2.6 ANGSTROMS RESOLUTION
Descriptor: SULFATE ION, T CELL CORECEPTOR CD8
Authors:Leahy, D.J, Axel, R, Hendrickson, W.A.
Deposit date:1992-01-16
Release date:1994-01-31
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution.
Cell(Cambridge,Mass.), 68, 1992
1TEN
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BU of 1ten by Molmil
STRUCTURE OF A FIBRONECTIN TYPE III DOMAIN FROM TENASCIN PHASED BY MAD ANALYSIS OF THE SELENOMETHIONYL PROTEIN
Descriptor: TENASCIN
Authors:Leahy, D.J, Hendrickson, W.A, Aukhil, I, Erickson, H.P.
Deposit date:1992-08-28
Release date:1993-10-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein.
Science, 258, 1992
1BAF
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BU of 1baf by Molmil
2.9 ANGSTROMS RESOLUTION STRUCTURE OF AN ANTI-DINITROPHENYL-SPIN-LABEL MONOCLONAL ANTIBODY FAB FRAGMENT WITH BOUND HAPTEN
Descriptor: IGG1-KAPPA AN02 FAB (HEAVY CHAIN), IGG1-KAPPA AN02 FAB (LIGHT CHAIN), N-(2-AMINO-ETHYL)-4,6-DINITRO-N'-(2,2,6,6-TETRAMETHYL-1-OXY-PIPERIDIN-4-YL)-BENZENE-1,3-DIAMINE
Authors:Leahy, D.J, Brunger, A.T, Fox, R.O, Hynes, T.R.
Deposit date:1992-01-16
Release date:1994-01-31
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:2.9 A resolution structure of an anti-dinitrophenyl-spin-label monoclonal antibody Fab fragment with bound hapten.
J.Mol.Biol., 221, 1991
1ZOP
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BU of 1zop by Molmil
CD11A I-DOMAIN WITH BOUND MAGNESIUM ION
Descriptor: CHLORIDE ION, I-DOMAIN FRAGMENT OF LFA-1, MANGANESE (II) ION
Authors:Leahy, D.J, Qu, A.
Deposit date:1996-06-21
Release date:1996-12-07
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin.
Structure, 4, 1996
1ZOO
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BU of 1zoo by Molmil
CD11A I-DOMAIN WITH BOUND MAGNESIUM ION
Descriptor: CHLORIDE ION, LEUKOCYTE ADHESION GLYCOPROTEIN, MAGNESIUM ION
Authors:Leahy, D.J, Qu, A.
Deposit date:1996-06-21
Release date:1996-12-07
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin.
Structure, 4, 1996
1ZON
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BU of 1zon by Molmil
CD11A I-DOMAIN WITHOUT BOUND CATION
Descriptor: LEUKOCYTE ADHESION GLYCOPROTEIN
Authors:Leahy, D.J, Qu, A.
Deposit date:1996-06-20
Release date:1996-12-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin.
Structure, 4, 1996
1LFA
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BU of 1lfa by Molmil
CD11A I-DOMAIN WITH BOUND MN++
Descriptor: CD11A, CHLORIDE ION, MANGANESE (II) ION
Authors:Leahy, D.J, Qu, A.
Deposit date:1995-09-08
Release date:1996-01-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.
Proc.Natl.Acad.Sci.USA, 92, 1995
1M6B
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BU of 1m6b by Molmil
Structure of the HER3 (ERBB3) Extracellular Domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor protein-tyrosine kinase erbB-3, ...
Authors:Leahy, D.J, Cho, H.-S.
Deposit date:2002-07-15
Release date:2002-08-02
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the extracellular region of HER3 reveals an interdomain tether.
Science, 297, 2002
2AHX
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BU of 2ahx by Molmil
Crystal structure of ErbB4/HER4 extracellular domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor tyrosine-protein kinase erbB-4, SULFATE ION, ...
Authors:Bouyain, S, Longo, P.A, Li, S, Ferguson, K.M, Leahy, D.J.
Deposit date:2005-07-28
Release date:2005-09-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.396 Å)
Cite:The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand
Proc.Natl.Acad.Sci.USA, 102, 2005
6JFV
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BU of 6jfv by Molmil
The crystal structure of 2B-2B complex from keratins 5 and 14 (C367A mutant of K14)
Descriptor: Keratin, type I cytoskeletal 14, type II cytoskeletal 5
Authors:Kim, M.S, Lee, C.H, Coulombe, P.A, Leahy, D.J.
Deposit date:2019-02-12
Release date:2020-01-22
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Function Analyses of a Keratin Heterotypic Complex Identify Specific Keratin Regions Involved in Intermediate Filament Assembly.
Structure, 28, 2020
3U7U
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BU of 3u7u by Molmil
Crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Neuregulin 1, Receptor tyrosine-protein kinase erbB-4
Authors:Liu, P, Cleveland IV, T.E, Bouyain, S, Longo, P.A, Leahy, D.J.
Deposit date:2011-10-14
Release date:2012-08-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:A single ligand is sufficient to activate EGFR dimers.
Proc.Natl.Acad.Sci.USA, 109, 2012
3TNU
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BU of 3tnu by Molmil
Heterocomplex of coil 2B domains of human intermediate filament proteins, keratin 5 (KRT5) and keratin 14 (KRT14)
Descriptor: Keratin, type I cytoskeletal 14, type II cytoskeletal 5
Authors:Lee, C.H, Kim, M.S, Leahy, D.J, Coulombe, P.A.
Deposit date:2011-09-02
Release date:2012-06-20
Last modified:2012-08-01
Method:X-RAY DIFFRACTION (3.005 Å)
Cite:Structural basis for heteromeric assembly and perinuclear organization of keratin filaments.
Nat.Struct.Mol.Biol., 19, 2012
3U2P
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BU of 3u2p by Molmil
Crystal structure of N-terminal three extracellular domains of ErbB4/Her4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor tyrosine-protein kinase erbB-4
Authors:Liu, P, Bouyain, S, Elgenbrot, C, Leahy, D.J.
Deposit date:2011-10-04
Release date:2011-11-09
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:The ErbB4 extracellular region retains a tethered-like conformation in the absence of the tether.
Protein Sci., 21, 2012
3U9U
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BU of 3u9u by Molmil
Crystal Structure of Extracellular Domain of Human ErbB4/Her4 in complex with the Fab fragment of mAb1479
Descriptor: Fab Heavy Chain, Fab Light Chain, Receptor tyrosine-protein kinase erbB-4
Authors:Hollmen, M, Liu, P, Wildiers, H, Reinvall, I, Vandorpe, T, Smeets, A, Deraedt, K, Vahlberg, T, Joensuu, H, Leahy, D.J, Schoffski, P, Elenius, K.
Deposit date:2011-10-19
Release date:2012-10-31
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:Proteolytic processing of ErbB4 in breast cancer.
Plos One, 7, 2012
3N1O
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BU of 3n1o by Molmil
Crystal structure of IhhN
Descriptor: CALCIUM ION, Indian hedgehog protein, ZINC ION
Authors:Kavran, J.M, Leahy, D.J.
Deposit date:2010-05-16
Release date:2010-06-02
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.
J.Biol.Chem., 285, 2010
3N1R
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BU of 3n1r by Molmil
Crystal Structure of ShhN
Descriptor: CALCIUM ION, Sonic hedgehog protein, ZINC ION
Authors:Kavran, J.M, Leahy, D.J.
Deposit date:2010-05-16
Release date:2010-06-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Crystal Structure of ShhN
TO BE PUBLISHED
3N1P
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BU of 3n1p by Molmil
Crystal Structure of IhhN bound to BOCFn3
Descriptor: Brother of CDO, CALCIUM ION, Indian hedgehog protein, ...
Authors:Kavran, J.M, Leahy, D.J.
Deposit date:2010-05-16
Release date:2010-06-02
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.
J.Biol.Chem., 285, 2010
3N1G
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BU of 3n1g by Molmil
Crystal structure of DhhN bound to BOCFn3
Descriptor: Brother of CDO, CALCIUM ION, Desert hedgehog protein, ...
Authors:Kavran, J.M, Leahy, D.J.
Deposit date:2010-05-15
Release date:2010-06-02
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.
J.Biol.Chem., 285, 2010
3N1Q
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BU of 3n1q by Molmil
Crystal Structure of DhhN bound to CDOFn3
Descriptor: CALCIUM ION, Cell adhesion molecule-related/down-regulated by oncogenes, Desert hedgehog protein, ...
Authors:Kavran, J.M, Leahy, D.J.
Deposit date:2010-05-16
Release date:2010-06-02
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.
J.Biol.Chem., 285, 2010
3N1F
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BU of 3n1f by Molmil
Crystal Structure of IhhN bound to CDOFn3
Descriptor: CALCIUM ION, Cell adhesion molecule-related/down-regulated by oncogenes, Indian hedgehog protein, ...
Authors:Kavran, J.M, Leahy, D.J.
Deposit date:2010-05-15
Release date:2010-06-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.
J.Biol.Chem., 285, 2010
3N1M
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BU of 3n1m by Molmil
Crystal Structure of IhhN bound to BOCFn3
Descriptor: Brother of CDO, CALCIUM ION, Indian hedgehog protein, ...
Authors:Kavran, J.M, Leahy, D.J.
Deposit date:2010-05-15
Release date:2010-06-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.
J.Biol.Chem., 285, 2010
3ODN
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BU of 3odn by Molmil
The crystal structure of Drosophila Dally-Like Protein core domain
Descriptor: Dally-like protein
Authors:Kim, M.-S, Leahy, D.J.
Deposit date:2010-08-11
Release date:2011-07-27
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling.
Proc.Natl.Acad.Sci.USA, 108, 2011
1AT0
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BU of 1at0 by Molmil
17-kDA fragment of hedgehog C-terminal autoprocessing domain
Descriptor: 17-HEDGEHOG
Authors:Hall, T.M.T, Porter, J.A, Young, K.E, Koonin, E.V, Beachy, P.A, Leahy, D.J.
Deposit date:1997-08-15
Release date:1997-11-12
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins.
Cell(Cambridge,Mass.), 91, 1997
1S78
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BU of 1s78 by Molmil
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Pertuzumab Fab heavy chain, ...
Authors:Franklin, M.C, Carey, K.D, Vajdos, F.F, Leahy, D.J, de Vos, A.M, Sliwkowski, M.X.
Deposit date:2004-01-29
Release date:2004-04-27
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex.
Cancer Cell, 5, 2004

 

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