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1EXM
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS ELONGATION FACTOR TU (EF-TU) IN COMPLEX WITH THE GTP ANALOGUE GPPNHP.
分子名称:ELONGATION FACTOR TU (EF-TU), MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Hogg, T., Mesters, J.R., Hilgenfeld, R.
登録日2000-05-03
公開日2000-06-07
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Insights into the GTPase Mechanism of EF-Tu from Structural Studies
The Ribosome: Structure, Function, Antibiotics, and Cellular Interactions, 28, 2000
5IDK
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CRYSTAL STRUCTURE OF WEST NILE VIRUS NS2B-NS3 PROTEASE IN COMPLEX WITH A CAPPED DIPEPTIDE BORONATE INHIBITOR
分子名称:Genome polyprotein,SERINE PROTEASE SUBUNIT NS2B, SERINE PROTEASE NS3, ((R)-1-((S)-3-(4-(aminomethyl)phenyl)-2-benzamidopropaneamido)-4-guanidinobutyl)boronic acid, ...
著者Hilgenfeld, R., Zhang, L.
登録日2016-02-24
公開日2016-12-14
最終更新日2017-09-06
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Peptide-Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology.
J. Med. Chem., 60, 2017
1HA3
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ELONGATION FACTOR TU IN COMPLEX WITH AURODOX
分子名称:ELONGATION FACTOR TU, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Vogeley, L., Palm, G.J., Mesters, J.R., Hilgenfeld, R.
登録日2001-03-26
公開日2001-05-15
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Conformational Change of Elongation Factor TU Induced by Antibiotic Binding: Crystal Structure of the Complex between EF-TU:Gdp and Aurodox
J.Biol.Chem., 276, 2001
1LK9
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THE THREE-DIMENSIONAL STRUCTURE OF ALLIINASE FROM GARLIC
分子名称:ALLIIN LYASE, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
著者Kuettner, E.B., Hilgenfeld, R., Weiss, M.S.
登録日2002-04-24
公開日2002-12-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献The active principle of garlic at atomic resolution
J.Biol.Chem., 277, 2002
1F13
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RECOMBINANT HUMAN CELLULAR COAGULATION FACTOR XIII
分子名称:CELLULAR COAGULATION FACTOR XIII ZYMOGEN
著者Weiss, M.S., Hilgenfeld, R.
登録日1998-01-16
公開日1998-08-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Two non-proline cis peptide bonds may be important for factor XIII function.
FEBS Lett., 423, 1998
1VIJ
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HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR HOE/BAY 793 HEXAGONAL FORM
分子名称:HIV-1 PROTEASE, N-(1-BENZYL-2,3-DIHYDROXY-4-{3-METHYL-2-[2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYLAMINO]-BUTYRYLAMINO}-5-PHENYL-PENTYL)-3-METHYL-2-[2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYLAMINO]-BUTYRAMIDE
著者Lange-Savage, G., Berchtold, H., Liesum, A., Hilgenfeld, R.
登録日1997-05-07
公開日1999-01-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of HOE/BAY 793 complexed to human immunodeficiency virus (HIV-1) protease in two different crystal forms--structure/function relationship and influence of crystal packing.
Eur.J.Biochem., 248, 1997
1VIK
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HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR HOE/BAY 793 ORTHORHOMBIC FORM
分子名称:HIV-1 PROTEASE, N-(1-BENZYL-2,3-DIHYDROXY-4-{3-METHYL-2-[2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYLAMINO]-BUTYRYLAMINO}-5-PHENYL-PENTYL)-3-METHYL-2-[2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYLAMINO]-BUTYRAMIDE
著者Lange-Savage, G., Berchtold, H., Liesum, A., Hilgenfeld, R.
登録日1997-05-07
公開日1998-12-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of HOE/BAY 793 complexed to human immunodeficiency virus (HIV-1) protease in two different crystal forms--structure/function relationship and influence of crystal packing.
Eur.J.Biochem., 248, 1997
2CIJ
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MEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) WITH BOUND METHIONINE
分子名称:GLUTAMATE CARBOXYPEPTIDASE II, METHIONINE, ZINC ION, ...
著者Barinka, C., Plechanovova, A., Rulisek, L., Mlcochova, P., Majer, P., Slusher, B.S., Hilgenfeld, R., Mesters, J.R., Konvalinka, J.
登録日2006-03-21
公開日2007-03-27
最終更新日2014-06-11
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Glutamate Carboxypeptidase II
Handbook of Metalloproteins, 4, 2011
2JBJ
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MEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) IN COMPLEX WITH 2-PMPA (2-PHOSPHONOMETHYL-PENTANEDIOIC ACID)
分子名称:GLUTAMATE CARBOXYPEPTIDASE 2, ZINC ION, CALCIUM ION, ...
著者Mesters, J.R., Henning, K., Hilgenfeld, R.
登録日2006-12-07
公開日2006-12-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Human Glutamate Carboxypeptidase II Inhibition: Structures of Gcpii in Complex with Two Potent Inhibitors, Quisqualate and 2-Pmpa.
Acta Crystallogr.,Sect.D, 63, 2007
2JBK
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MEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) IN COMPLEX WITH QUISQUALIC ACID (QUISQUALATE, ALPHA-AMINO-3,5-DIOXO-1,2,4- OXADIAZOLIDINE-2-PROPANOIC ACID)
分子名称:GLUTAMATE CARBOXYPEPTIDASE 2, ZINC ION, CALCIUM ION, ...
著者Mesters, J.R., Henning, K., Hilgenfeld, R.
登録日2006-12-07
公開日2006-12-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献Human Glutamate Carboxypeptidase II Inhibition: Structures of Gcpii in Complex with Two Potent Inhibitors, Quisqualate and 2-Pmpa.
Acta Crystallogr.,Sect.D, 63, 2007
2Q8W
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CRYSTAL STRUCTURE OF PAP-S1ACI, A POKEWEED ANTIVIRAL PROTEIN FROM SEEDS OF PHYTOLACCA ACINOSA
分子名称:POKEWEED ANTIVIRAL PROTEIN, N-ACETYL-D-GLUCOSAMINE
著者Hogg, T., Hilgenfeld, R.
登録日2007-06-12
公開日2008-06-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The complete covalent structure and 1.7 A crystal structure of PAP-S1aci reveals a RIP glycoprotein with multiple Asn-GlcNAc modifications
To be Published
2XCI
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MEMBRANE-EMBEDDED MONOFUNCTIONAL GLYCOSYLTRANSFERASE WAAA OF AQUIFEX AEOLICUS, SUBSTRATE-FREE FORM
分子名称:3-DEOXY-D-MANNO-2-OCTULOSONIC ACID TRANSFERASE, TETRAETHYLENE GLYCOL, GLYCEROL, ...
著者Schmidt, H., Hansen, G., Hilgenfeld, R., Mamat, U., Mesters, J.R.
登録日2010-04-26
公開日2011-05-11
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and Mechanistic Analysis of the Membrane-Embedded Glycosyltransferase Waaa Required for Lipopolysaccharide Synthesis.
Proc.Natl.Acad.Sci.USA, 109, 2012
2XCU
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MEMBRANE-EMBEDDED MONOFUNCTIONAL GLYCOSYLTRANSFERASE WAAA OF AQUIFEX AEOLICUS, COMPLEX WITH CMP
分子名称:3-DEOXY-D-MANNO-2-OCTULOSONIC ACID TRANSFERASE, CYTIDINE-5'-MONOPHOSPHATE, PENTAETHYLENE GLYCOL, ...
著者Schmidt, H., Hansen, G., Hilgenfeld, R., Mamat, U., Mesters, J.R.
登録日2010-04-26
公開日2011-05-11
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Structural and Mechanistic Analysis of the Membrane-Embedded Glycosyltransferase Waaa Required for Lipopolysaccharide Synthesis.
Proc.Natl.Acad.Sci.USA, 109, 2012
2J97
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HUMAN CORONAVIRUS 229E NON STRUCTURAL PROTEIN 9 (NSP9)
分子名称:REPLICASE POLYPROTEIN 1AB, (4S)-2-METHYL-2,4-PENTANEDIOL, SULFATE ION
著者Ponnusamy, R., Mesters, J.R., Moll, R., Hilgenfeld, R.
登録日2006-11-03
公開日2007-11-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Variable Oligomerization Modes in Coronavirus Non-Structural Protein 9.
J.Mol.Biol., 383, 2008
2J98
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HUMAN CORONAVIRUS 229E NON STRUCTURAL PROTEIN 9 CYS69ALA MUTANT (NSP9)
分子名称:REPLICASE POLYPROTEIN 1AB, 2,3-DIHYDROXY-1,4-DITHIOBUTANE
著者Ponnusamy, R., Mesters, J.R., Moll, R., Hilgenfeld, R.
登録日2006-11-03
公開日2007-11-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Variable Oligomerization Modes in Coronavirus Non-Structural Protein 9.
J.Mol.Biol., 383, 2008
2VB0
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CRYSTAL STRUCTURE OF COXSACKIEVIRUS B3 PROTEINASE 3C
分子名称:POLYPROTEIN 3BCD, CHLORIDE ION
著者Anand, K., Mesters, J.R., Goerlach, R., Zell, R., Hilgenfeld, R.
登録日2007-09-05
公開日2008-10-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structure of Coxsackie Virus B3 Proteinase 3C
To be Published
1JFX
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CRYSTAL STRUCTURE OF THE BACTERIAL LYSOZYME FROM STREPTOMYCES COELICOLOR AT 1.65 A RESOLUTION
分子名称:1,4-beta-N-Acetylmuramidase M1, CHLORIDE ION
著者Rau, A., Hogg, T., Marquardt, R., Hilgenfeld, R.
登録日2001-06-22
公開日2001-09-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献A new lysozyme fold. Crystal structure of the muramidase from Streptomyces coelicolor at 1.65 A resolution.
J.Biol.Chem., 276, 2001
2VRI
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STRUCTURE OF THE NSP3 X-DOMAIN OF HUMAN CORONAVIRUS NL63
分子名称:NON-STRUCTURAL PROTEIN 3, 1,2-ETHANEDIOL
著者Piotrowski, Y., Mesters, J.R., Moll, R., Hilgenfeld, R.
登録日2008-04-08
公開日2009-06-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of the Nsp3 X-Domain of Human Coronavirus Nl63
To be Published
3O5Z
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CRYSTAL STRUCTURE OF THE SH3 DOMAIN FROM P85BETA SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE (PI3K)
分子名称:Phosphatidylinositol 3-kinase regulatory subunit beta, CHLORIDE ION, (4S)-2-METHYL-2,4-PENTANEDIOL
著者Chen, S., Xiao, Y., Ponnusamy, R., Tan, J., Lei, J., Hilgenfeld, R.
登録日2010-07-28
公開日2011-08-10
最終更新日2014-09-10
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献X-ray structure of the SH3 domain of the phosphoinositide 3-kinase p85 beta subunit
Acta Crystallogr.,Sect.F, 67, 2011
3P31
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CRYSTAL STRUCTURE OF THE NS1 EFFECTOR DOMAIN FROM INFLUENZA A/VIETNAM/1203/2004 (H5N1) VIRUS
分子名称:Nonstructural protein 1, THIOCYANATE ION
著者Chen, S., Xiao, Y.B., Ponnusamy, R., Hilgenfeld, R.
登録日2010-10-04
公開日2011-10-05
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献X-ray structures of the NS1 effector domain from highly pathogenic influenza A/Vietnam/1203/2004 (H5N1) virus
To be Published
3PV2
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STRUCTURE OF LEGIONELLA FALLONII DEGQ (WT)
分子名称:DegQ
著者Wrase, R., Scott, H., Hilgenfeld, R., Hansen, G.
登録日2010-12-06
公開日2011-06-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献The Legionella HtrA homologue DegQ is a self-compartmentizing protease that forms large 12-meric assemblies.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PV3
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STRUCTURE OF LEGIONELLA FALLONII DEGQ (S193A VARIANT)
分子名称:DegQ, Substrate peptide (Poly-Ala)
著者Wrase, R., Scott, H., Hilgenfeld, R., Hansen, G.
登録日2010-12-06
公開日2011-06-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献The Legionella HtrA homologue DegQ is a self-compartmentizing protease that forms large 12-meric assemblies.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PV4
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STRUCTURE OF LEGIONELLA FALLONII DEGQ (DELTA-PDZ2 VARIANT)
分子名称:DegQ, CADMIUM ION
著者Wrase, R., Scott, H., Hilgenfeld, R., Hansen, G.
登録日2010-12-06
公開日2011-06-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献The Legionella HtrA homologue DegQ is a self-compartmentizing protease that forms large 12-meric assemblies.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PV5
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STRUCTURE OF LEGIONELLA FALLONII DEGQ (N189G/P190G VARIANT)
分子名称:DegQ
著者Wrase, R., Scott, H., Hilgenfeld, R., Hansen, G.
登録日2010-12-06
公開日2011-06-15
最終更新日2018-03-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The Legionella HtrA homologue DegQ is a self-compartmentizing protease that forms large 12-meric assemblies.
Proc.Natl.Acad.Sci.USA, 108, 2011
4YNN
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STRUCTURE OF LEGIONELLA PNEUMOPHILA DEGQ (S190A VARIANT)
分子名称:Protease DO, Octapeptide, Hexa-peptide, ...
著者Wrase, R., Hilgenfeld, R., Hansen, G.
登録日2015-03-10
公開日2015-06-24
最終更新日2015-08-26
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structures of DegQ from Legionella pneumophila Define Distinct ON and OFF States.
J.Mol.Biol., 427, 2015