2JBJ

membrane-bound glutamate carboxypeptidase II (GCPII) in complex with 2-PMPA (2-phosphonoMethyl-pentanedioic acid)

Summary for 2JBJ

• Entry DOI: 10.2210/pdb2jbj/pdb
• Related: 1Z8L 2C6C 2C6G 2C6P 2CIJ 2JBK
• Descriptor: GLUTAMATE CARBOXYPEPTIDASE 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: multifunctional enzyme, neurodegenerative disease, glycoprotein, metal-binding, signal-anchor, hydrolase, naaladase, dipeptidase, polymorphism, zinc, psma, antigen, membrane, protease, peptidase, transmembrane, metal- binding, metalloprotease, prostate cancer, carboxypeptidase, alternative splicing
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm: Q04609
• Total number of polymer chains: 1
• Total formula weight: 82732.73

Authors

Mesters, J.R.,Henning, K.,Hilgenfeld, R. (deposition date: 2006-12-07, release date: 2006-12-18, Last modification date: 2020-07-29)

• Primary citation: Mesters, J.R.,Henning, K.,Hilgenfeld, R.; Human Glutamate Carboxypeptidase II Inhibition: Structures of Gcpii in Complex with Two Potent Inhibitors, Quisqualate and 2-Pmpa.; Acta Crystallogr.,Sect.D, 63:508-, 2007; PubMed: 17372356; DOI: 10.1107/S090744490700902X

Experimental method

X-RAY DIFFRACTION (2.19 Å)