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1C5G
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PLASMINOGEN ACTIVATOR INHIBITOR-1
Descriptor:PLASMINOGEN ACTIVATOR INHIBITOR-1
Authors:Goldsmith, E.J.
Deposit date:1999-12-07
Release date:1999-12-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Engineering of plasminogen activator inhibitor-1 to reduce the rate of latency transition.
Nat.Struct.Biol., 2, 1995
1ERK
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STRUCTURE OF SIGNAL-REGULATED KINASE
Descriptor:EXTRACELLULAR REGULATED KINASE 2
Authors:Harkins, P.C., Goldsmith, E.J.
Deposit date:1996-08-06
Release date:1997-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Atomic structure of the MAP kinase ERK2 at 2.3 A resolution.
Nature, 367, 1994
1GOL
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COORDINATES OF RAT MAP KINASE ERK2 WITH AN ARGININE MUTATION AT POSITION 52
Descriptor:EXTRACELLULAR REGULATED KINASE 2, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Harkins, P.C., Zhang, F., Goldsmith, E.J.
Deposit date:1996-01-23
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate.
Biochemistry, 35, 1996
1A9U
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THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB203580
Descriptor:MAP KINASE P38, 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE
Authors:Wang, Z., Canagarajah, B., Boehm, J.C., Kassis, S., Cobb, M.H., Young, P.R., Abdel-Meguid, S., Adams, J.L., Goldsmith, E.J.
Deposit date:1998-04-10
Release date:1999-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
1BL6
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THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB216995
Descriptor:PROTEIN (MAP KINASE P38), 4-(4-FLUOROPHENYL)-1-CYCLOROPROPYLMETHYL-5-(4-PYRIDYL)-IMIDAZOLE
Authors:Wang, Z., Canagarajah, B.J., Boehm, J.C., Kassis, S., Cobb, M.H., Young, P.R., Abdel-Meguid, S., Adams, J.L., Goldsmith, E.J.
Deposit date:1998-07-11
Release date:1999-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
1BL7
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THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB220025
Descriptor:PROTEIN (MAP KINASE P38), 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE
Authors:Wang, Z., Canagarajah, B.J., Boehm, J.C., Kassis, S., Cobb, M.H., Young, P.R., Abdel-Meguid, S., Adams, J.L., Goldsmith, E.J.
Deposit date:1998-07-23
Release date:1999-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
1BMK
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THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB218655
Descriptor:PROTEIN (MAP KINASE P38), 4-(FLUOROPHENYL)-1-CYCLOPROPYLMETHYL-5-(2-AMINO-4-PYRIMIDINYL)IMIDAZOLE
Authors:Wang, Z., Canagarajah, B., Boehm, J.C., Kassis, S., Cobb, M.H., Young, P.R., Abdel-Meguid, S., Adams, J.L., Goldsmith, E.J.
Deposit date:1998-07-23
Release date:1999-07-23
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
1F3T
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CRYSTAL STRUCTURE OF TRYPANOSOMA BRUCEI ORNITHINE DECARBOXYLASE (ODC) COMPLEXED WITH PUTRESCINE, ODC'S REACTION PRODUCT.
Descriptor:ORNITHINE DECARBOXYLASE, PYRIDOXAL-5'-PHOSPHATE, 1,4-DIAMINOBUTANE
Authors:Jackson, L.K., Brooks, H.B., Osterman, A.L., Goldsmith, E.J., Phillips, M.A.
Deposit date:2000-06-06
Release date:2000-11-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Altering the reaction specificity of eukaryotic ornithine decarboxylase.
Biochemistry, 39, 2000
1K9O
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CRYSTAL STRUCTURE OF MICHAELIS SERPIN-TRYPSIN COMPLEX
Descriptor:ALASERPIN, TRYPSIN II ANIONIC
Authors:Ye, S., Cech, A.L., Belmares, R., Bergstrom, R.C., Tong, Y., Corey, D.R., Kanost, M.R., Goldsmith, E.J.
Deposit date:2001-10-29
Release date:2001-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of a Michaelis serpin-protease complex.
Nat.Struct.Biol., 8, 2001
1LEW
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CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS NUCLEAR SUBSTRATE MEF2A
Descriptor:Mitogen-activated protein kinase 14, Myocyte-specific enhancer factor 2A
Authors:Chang, C.-I., Xu, B.-E., Akella, R., Cobb, M.H., Goldsmith, E.J.
Deposit date:2002-04-10
Release date:2002-07-10
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b.
Mol.Cell, 9, 2002
1LEZ
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CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS ACTIVATOR MKK3B
Descriptor:MITOGEN-ACTIVATED PROTEIN KINASE 14, MAP kinase kinase 3b
Authors:Chang, C.-I., Xu, B.-E., Akella, R., Cobb, M.H., Goldsmith, E.J.
Deposit date:2002-04-10
Release date:2002-07-10
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b.
Mol.Cell, 9, 2002
1LLQ
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CRYSTAL STRUCTURE OF MALIC ENZYME FROM ASCARIS SUUM COMPLEXED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE
Descriptor:NAD-dependent malic enzyme, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Coleman, D.E., Jagannatha, G.S., Goldsmith, E.J., Cook, P.F., Harris, B.G.
Deposit date:2002-04-29
Release date:2002-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the malic enzyme from Ascaris suum complexed with nicotinamide adenine dinucleotide at 2.3 A resolution.
Biochemistry, 41, 2002
1NJJ
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CRYSTAL STRUCTURE DETERMINATION OF T. BRUCEI ORNITHINE DECARBOXYLASE BOUND TO D-ORNITHINE AND TO G418
Descriptor:ornithine decarboxylase, GENETICIN, N~2~-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-D-ORNITHINE
Authors:Jackson, L.K., Goldsmith, E.J., Phillips, M.A.
Deposit date:2002-12-31
Release date:2003-08-26
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:X-ray Structure Determination of Trypanosoma brucei Ornithine Decarboxylase Bound to D-Ornithine and to G418: INSIGHTS INTO SUBSTRATE BINDING AND ODC CONFORMATIONAL FLEXIBILITY.
J.Biol.Chem., 278, 2003
1QU4
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CRYSTAL STRUCTURE OF TRYPANOSOMA BRUCEI ORNITHINE DECARBOXYLASE
Descriptor:ORNITHINE DECARBOXYLASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Grishin, N.V., Osterman, A.L., Brooks, H.B., Phillips, M.A., Goldsmith, E.J.
Deposit date:1999-07-06
Release date:1999-11-17
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:X-ray structure of ornithine decarboxylase from Trypanosoma brucei: the native structure and the structure in complex with alpha-difluoromethylornithine.
Biochemistry, 38, 1999
1SEK
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THE STRUCTURE OF ACTIVE SERPIN K FROM MANDUCA SEXTA AND A MODEL FOR SERPIN-PROTEASE COMPLEX FORMATION
Descriptor:SERPIN K
Authors:Li, J., Wang, Z., Canagarajah, B., Jiang, H., Kanost, M., Goldsmith, E.J.
Deposit date:1998-03-06
Release date:1999-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of active serpin 1K from Manduca sexta.
Structure Fold.Des., 7, 1999
1SZR
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A DIMER INTERFACE MUTANT OF ORNITHINE DECARBOXYLASE REVEALS STRUCTURE OF GEM DIAMINE INTERMEDIATE
Descriptor:Ornithine decarboxylase, PYRIDOXINE-5'-PHOSPHATE, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], ...
Authors:Jackson, L.K., Baldwin, J., Goldsmith, E.J., Phillips, M.A.
Deposit date:2004-04-06
Release date:2004-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Multiple active site conformations revealed by distant site mutation in ornithine decarboxylase
Biochemistry, 43, 2004
1U5Q
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CRYSTAL STRUCTURE OF THE TAO2 KINASE DOMAIN: ACTIVATION AND SPECIFITY OF A STE20P MAP3K
Descriptor:serine/threonine protein kinase TAO2, CALCIUM ION
Authors:Zhou, T., Raman, M., Gao, Y., Earnest, S., Chen, Z., Machius, M., Cobb, M.H., Goldsmith, E.J.
Deposit date:2004-07-28
Release date:2004-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the TAO2 Kinase Domain; Activation and Specificity of a Ste20p MAP3K.
STRUCTURE, 12, 2004
1U5R
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CRYSTAL STRUCTURE OF THE TAO2 KINASE DOMAIN: ACTIVATION AND SPECIFITY OF A STE20P MAP3K
Descriptor:serine/threonine protein kinase TAO2, MAGNESIUM ION, CALCIUM ION, ...
Authors:Zhou, T., Raman, M., Gao, Y., Earnest, S., Chen, Z., Machius, M., Cobb, M.H., Goldsmith, E.J.
Deposit date:2004-07-28
Release date:2004-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the TAO2 Kinase Domain; Activation and Specificity of a Ste20p MAP3K.
Structure, 12, 2004
2ERK
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PHOSPHORYLATED MAP KINASE ERK2
Descriptor:EXTRACELLULAR SIGNAL-REGULATED KINASE 2
Authors:Canagarajah, B.J., Goldsmith, E.J.
Deposit date:1997-06-26
Release date:1998-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Activation mechanism of the MAP kinase ERK2 by dual phosphorylation.
Cell(Cambridge,Mass.), 90, 1997
2GCD
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TAO2 KINASE DOMAIN-STAUROSPORINE STRUCTURE
Descriptor:Serine/threonine-protein kinase TAO2, STAUROSPORINE
Authors:Zhou, T., Sun, L., Gao, Y., Earnest, S., Cobb, M.H., Goldsmith, E.J.
Deposit date:2006-03-14
Release date:2006-09-05
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of the MAP3K TAO2 kinase domain bound by an inhibitor staurosporine.
Acta Biochim.Biophys.Sinica, 38, 2006
2GPH
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DOCKING MOTIF INTERACTIONS IN THE MAP KINASE ERK2
Descriptor:Mitogen-activated protein kinase 1, Tyrosine-protein phosphatase non-receptor type 7
Authors:Zhou, T., Sun, L., Humphreys, J., Goldsmith, E.J.
Deposit date:2006-04-17
Release date:2006-07-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Docking Interactions Induce Exposure of Activation Loop in the MAP Kinase ERK2.
Structure, 14, 2006
2LRU
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SOLUTION STRUCTURE OF THE WNK1 AUTOINHIBITORY DOMAIN
Descriptor:Serine/threonine-protein kinase WNK1
Authors:Moon, T.M., Correa, F., Gardner, K.H., Goldsmith, E.J.
Deposit date:2012-04-13
Release date:2012-05-23
Last modified:2013-04-24
Method:SOLUTION NMR
Cite:Solution Structure of the WNK1 Autoinhibitory Domain, a WNK-Specific PF2 Domain.
J.Mol.Biol., 425, 2013
2PLJ
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CRYSTAL STRUCTURE OF LYSINE/ORNITHINE DECARBOXYLASE COMPLEXED WITH PUTRESCINE FROM VIBRIO VULNIFICUS
Descriptor:lysine/ornithine decarboxylase, MAGNESIUM ION, (4-{[(4-AMINOBUTYL)AMINO]METHYL}-5-HYDROXY-6-METHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE
Authors:Lee, J., Goldsmith, E.J., Phillips, M.A.
Deposit date:2007-04-19
Release date:2007-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Phylogenetic diversity and the structural basis of substrate specificity in the beta/alpha-barrel fold basic amino acid decarboxylases.
J.Biol.Chem., 282, 2007
2PLK
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CRYSTAL STRUCTURE OF LYSINE/ORNITHINE DECARBOXYLASE COMPLEXED WITH CADAVERINE FROM VIBRIO VULNIFICUS
Descriptor:lysine/ornithine decarboxylase, (4-{(E)-[(5-AMINOPENTYL)IMINO]METHYL}-5-HYDROXY-6-METHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE
Authors:Lee, J., Goldsmith, E.J., Phillips, M.A.
Deposit date:2007-04-19
Release date:2007-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Phylogenetic diversity and the structural basis of substrate specificity in the beta/alpha-barrel fold basic amino acid decarboxylases.
J.Biol.Chem., 282, 2007
2TOD
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ORNITHINE DECARBOXYLASE FROM TRYPANOSOMA BRUCEI K69A MUTANT IN COMPLEX WITH ALPHA-DIFLUOROMETHYLORNITHINE
Descriptor:PROTEIN (ORNITHINE DECARBOXYLASE), ALPHA-DIFLUOROMETHYLORNITHINE, PYRIDOXAL-5'-PHOSPHATE
Authors:Grishin, N.V., Osterman, A.L., Brooks, H.B., Phillips, M.A., Goldsmith, E.J.
Deposit date:1999-05-18
Release date:1999-11-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structure of ornithine decarboxylase from Trypanosoma brucei: the native structure and the structure in complex with alpha-difluoromethylornithine.
Biochemistry, 38, 1999
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