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2XY9
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BU of 2xy9 by Molmil
Human Angiotensin converting enzyme in complex with phosphinic tripeptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, ...
Authors:Akif, M, Schwager, S.L, Anthony, C.S, Czarny, B, Beau, F, Dive, V, Sturrock, E.D, Acharya, K.R.
Deposit date:2010-11-16
Release date:2011-05-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Novel Mechanism of Inhibition of Human Angiotensin-I-Converting Enzyme (Ace) by a Highly Specific Phosphinic Tripeptide.
Biochem.J., 436, 2011
7ANQ
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BU of 7anq by Molmil
Complete PCSK9 C-ter domain in complex with VHH P1.40
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Proprotein convertase subtilisin/kexin type 9, SULFATE ION, ...
Authors:Ciccone, L, Legrand, P, Stura, E.A, Dive, V, Seidahn, N.G, Fruchart Gaillard, C.
Deposit date:2020-10-12
Release date:2021-10-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular interactions of PCSK9 with an inhibitory nanobody, CAP1 and HLA-C: Functional regulation of LDLR levels.
Mol Metab, 67, 2022
4WZV
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BU of 4wzv by Molmil
Crystal structure of a hydroxamate based inhibitor EN140 in complex with the MMP-9 catalytic domain
Descriptor: (2R)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-hydroxy-2-{[(4'-methoxybiphenyl-4-yl)sulfonyl](propan-2-yloxy)amino}butanamide, 1,2-ETHANEDIOL, AZIDE ION, ...
Authors:Stura, E.A, Vera, L, Cassar-Lajeunesse, E, Nuti, E, Dive, V, Rossello, A.
Deposit date:2014-11-20
Release date:2015-08-26
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity.
J.Med.Chem., 58, 2015
4XCT
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BU of 4xct by Molmil
Crystal structure of a hydroxamate based inhibitor ARP101 (EN73) in complex with the MMP-9 catalytic domain.
Descriptor: (2S,3S)-butane-2,3-diol, (2~{R})-3-methyl-~{N}-oxidanylidene-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxy-amino]butanamide, 1,2-ETHANEDIOL, ...
Authors:Stura, E.A, Tepshi, L, Nuti, E, Dive, V, Cassar-Lajeunesse, E, Vera, L, Rossello, A.
Deposit date:2014-12-18
Release date:2015-04-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity.
J.Med.Chem., 58, 2015
2XYD
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BU of 2xyd by Molmil
human Angiotenisn converting enzyme N-domain in complex with Phosphinic tripeptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANGIOTENSIN-CONVERTING ENZYME, CHLORIDE ION, ...
Authors:Akif, M, Schwager, S.L, Anthony, C.S, Czarny, B, Beau, F, Dive, V, Sturrock, E.D, Acharya, K.R.
Deposit date:2010-11-17
Release date:2011-05-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Novel Mechanism of Inhibition of Human Angiotensin-I-Converting Enzyme (Ace) by a Highly Specific Phosphinic Tripeptide.
Biochem.J., 436, 2011
3LJG
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BU of 3ljg by Molmil
Human MMP12 in complex with non-zinc chelating inhibitor
Descriptor: ACETOHYDROXAMIC ACID, CALCIUM ION, HEXAETHYLENE GLYCOL, ...
Authors:Stura, E.A, Dive, V, Devel, L, Vera, L, Beau, F.
Deposit date:2010-01-26
Release date:2010-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.313 Å)
Cite:Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation.
J.Biol.Chem., 285, 2010
3LIR
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BU of 3lir by Molmil
Human MMP12 in complex with non-zinc chelating inhibitor
Descriptor: CALCIUM ION, GLYCINE, Macrophage metalloelastase, ...
Authors:Stura, E.A, Dive, V, Devel, L, Czarny, B, Vera, L, Beau, F.
Deposit date:2010-01-25
Release date:2010-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation.
J.Biol.Chem., 285, 2010
3LIL
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BU of 3lil by Molmil
Human MMP12 in complex with non-zinc chelating inhibitor
Descriptor: ACETOHYDROXAMIC ACID, CALCIUM ION, Macrophage metalloelastase, ...
Authors:Stura, E.A, Dive, V, Devel, L, Czarny, B, Vera, L, Beau, F.
Deposit date:2010-01-25
Release date:2010-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation.
J.Biol.Chem., 285, 2010
3LIK
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BU of 3lik by Molmil
Human MMP12 in complex with non-zinc chelating inhibitor
Descriptor: ACETOHYDROXAMIC ACID, CALCIUM ION, HEXAETHYLENE GLYCOL, ...
Authors:Stura, E.A, Dive, V, Devel, L, Czarny, B, Vera, L, Beau, F.
Deposit date:2010-01-25
Release date:2010-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation.
J.Biol.Chem., 285, 2010
2OC2
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BU of 2oc2 by Molmil
Structure of testis ACE with RXPA380
Descriptor: Angiotensin-converting enzyme, somatic isoform, CHLORIDE ION, ...
Authors:Corradi, H.R, Anthony, C.S, Schwager, S.L, Redelinghuys, P, Georgiadis, D, Dive, V, Acharya, K.R, Sturrock, E.D.
Deposit date:2006-12-20
Release date:2007-05-22
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The structure of testis angiotensin-converting enzyme in complex with the C domain-specific inhibitor RXPA380.
Biochemistry, 46, 2007
5L7F
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BU of 5l7f by Molmil
Crystal structure of MMP12 mutant K421A in complex with RXP470.1 conjugated with fluorophore Cy5,5 in space group P21.
Descriptor: 1,2-ETHANEDIOL, BROMIDE ION, CALCIUM ION, ...
Authors:Tepshi, L, Bordenave, T, Rouanet-Mehouas, C, Devel, L, Dive, V, Stura, E.A.
Deposit date:2016-06-03
Release date:2016-09-14
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Synthesis and in Vitro and in Vivo Evaluation of MMP-12 Selective Optical Probes.
Bioconjug.Chem., 27, 2016
5L79
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BU of 5l79 by Molmil
Crystal structure of MMP12 in complex with RXP470.1 conjugated with fluorophore Cy5,5 in space group P21212.
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, CY5.5-PEG2, ...
Authors:Tepshi, L, Bordenave, T, Devel, L, Dive, V, Stura, E.A.
Deposit date:2016-06-02
Release date:2016-09-14
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Synthesis and in Vitro and in Vivo Evaluation of MMP-12 Selective Optical Probes.
Bioconjug.Chem., 27, 2016
4H3X
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BU of 4h3x by Molmil
Crystal structure of an MMP broad spectrum hydroxamate based inhibitor CC27 in complex with the MMP-9 catalytic domain
Descriptor: CALCIUM ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Stura, E.A, Vera, L, Cassar-Lajeunesse, E, Nuti, E, Dive, V, Rossello, A.
Deposit date:2012-09-14
Release date:2013-04-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.764 Å)
Cite:Crystallization of bi-functional ligand protein complexes.
J.Struct.Biol., 182, 2013
4H76
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BU of 4h76 by Molmil
Crystal structure of the catalytic domain of Human MMP12 in complex with a broad spectrum hydroxamate inhibitor
Descriptor: CALCIUM ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Stura, E.A, Vera, L, Cassar-Lajeunesse, E, Nuti, E, Dive, V, Rossello, A.
Deposit date:2012-09-20
Release date:2013-04-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystallization of bi-functional ligand protein complexes.
J.Struct.Biol., 182, 2013
4CA8
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BU of 4ca8 by Molmil
Drosophila Angiotensin converting enzyme (AnCE) in complex with a phosphinic tripeptide FII
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ANGIOTENSIN-CONVERTING ENZYME, SULFATE ION, ...
Authors:Masuyer, G, Akif, M, Czarny, B, Beau, F, Schwager, S.L.U, Sturrock, E.D, Isaac, R.E, Dive, V, Acharya, K.R.
Deposit date:2013-10-07
Release date:2013-12-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Crystal Structures of Highly Specific Phosphinic Tripeptide Enantiomers in Complex with the Angiotensin-I Converting Enzyme.
FEBS J., 281, 2014
4CA5
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BU of 4ca5 by Molmil
Human Angiotensin converting enzyme in complex with a phosphinic tripeptide FI
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ...
Authors:Masuyer, G, Akif, M, Czarny, B, Beau, F, Schwager, S.L.U, Sturrock, E.D, Isaac, R.E, Dive, V, Acharya, K.R.
Deposit date:2013-10-07
Release date:2013-12-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structures of Highly Specific Phosphinic Tripeptide Enantiomers in Complex with the Angiotensin-I Converting Enzyme.
FEBS J., 281, 2014
4CA6
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BU of 4ca6 by Molmil
Human Angiotensin converting enzyme N-domain in complex with a phosphinic tripeptide FI
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANGIOTENSIN-CONVERTING ENZYME N-DOMAIN, CHLORIDE ION, ...
Authors:Masuyer, G, Akif, M, Czarny, B, Beau, F, Schwager, S.L.U, Sturrock, E.D, Isaac, R.E, Dive, V, Acharya, K.R.
Deposit date:2013-10-07
Release date:2013-12-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme.
FEBS J., 281, 2014
4CA7
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BU of 4ca7 by Molmil
Drosophila Angiotensin converting enzyme (AnCE) in complex with a phosphinic tripeptide FI
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ANGIOTENSIN-CONVERTING ENZYME, N-{(2S)-3-[(S)-[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl]-2-[(3-phenyl-1,2-oxazol-5-yl)methyl]propanoyl}-L-tyrosine, ...
Authors:Masuyer, G, Akif, M, Czarny, B, Beau, F, Schwager, S.L.U, Sturrock, E.D, Isaac, R.E, Dive, V, Acharya, K.R.
Deposit date:2013-10-07
Release date:2013-12-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal Structures of Highly Specific Phosphinic Tripeptide Enantiomers in Complex with the Angiotensin-I Converting Enzyme.
FEBS J., 281, 2014
4H84
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BU of 4h84 by Molmil
Crystal structure of the catalytic domain of Human MMP12 in complex with a selective carboxylate based inhibitor.
Descriptor: CALCIUM ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Stura, E.A, Antoni, C, Vera, L, Cassar-Lajeunesse, E, Nuti, E, Dive, V, Rossello, A.
Deposit date:2012-09-21
Release date:2013-04-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.592 Å)
Cite:Crystallization of bi-functional ligand protein complexes.
J.Struct.Biol., 182, 2013
1HV5
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BU of 1hv5 by Molmil
CRYSTAL STRUCTURE OF THE STROMELYSIN-3 (MMP-11) CATALYTIC DOMAIN COMPLEXED WITH A PHOSPHINIC INHIBITOR
Descriptor: 1-BENZYLOXYCARBONYLAMINO-2-PHENYL-ETHYL)-{2-[1-CARBAMOYL-2-(1H-INDOL-3-YL)-ETHYLCARBAMOYL]-5-PHENYL-PENTYL}-PHOSPHINIC ACID, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, CALCIUM ION, ...
Authors:Gall, A.L, Ruff, M, Kannan, R, Cuniasse, P, Yiotakis, A, Dive, V, Rio, M.C, Basset, P, Moras, D.
Deposit date:2001-01-08
Release date:2001-03-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the stromelysin-3 (MMP-11) catalytic domain complexed with a phosphinic inhibitor mimicking the transition-state.
J.Mol.Biol., 307, 2001
1LFW
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BU of 1lfw by Molmil
Crystal structure of pepV
Descriptor: 3-[(1-AMINO-2-CARBOXY-ETHYL)-HYDROXY-PHOSPHINOYL]-2-METHYL-PROPIONIC ACID, ZINC ION, pepV
Authors:Jozic, D, Bourenkow, G, Bartunik, H, Scholze, H, Dive, V, Henrich, B, Huber, R, Bode, W, Maskos, K.
Deposit date:2002-04-12
Release date:2002-10-23
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of the Dinuclear Zinc Aminopeptidase PepV from Lactobacillus delbrueckii Unravels Its Preference for Dipeptides
Structure, 10, 2002
4GR0
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BU of 4gr0 by Molmil
Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470B
Descriptor: CALCIUM ION, Macrophage metalloelastase, N-[(2S)-3-[(R)-(4-bromophenyl)(hydroxy)phosphoryl]-2-{[3-(3'-chlorobiphenyl-4-yl)-1,2-oxazol-5-yl]methyl}propanoyl]-L-a lanyl-L-alaninamide, ...
Authors:Stura, E.A, Vera, L, Beau, F, Devel, L, Cassar-Lajeunesse, E, Dive, V.
Deposit date:2012-08-24
Release date:2013-02-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.497 Å)
Cite:Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies.
J.Med.Chem., 56, 2013
4GQL
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BU of 4gql by Molmil
Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470.1
Descriptor: CALCIUM ION, Macrophage metalloelastase, N-[(2S)-3-[(S)-(4-bromophenyl)(hydroxy)phosphoryl]-2-{[3-(3'-chlorobiphenyl-4-yl)-1,2-oxazol-5-yl]methyl}propanoyl]-L-alpha-glutamyl-L-alpha-glutamine, ...
Authors:Stura, E.A, Vera, L, Beau, F, Devel, L, Cassar-Lajeunesse, E, Dive, V.
Deposit date:2012-08-23
Release date:2013-02-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies.
J.Med.Chem., 56, 2013
4GR3
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BU of 4gr3 by Molmil
Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470A
Descriptor: CALCIUM ION, Macrophage metalloelastase, N-{(2S)-3-[(S)-(4-bromophenyl)(hydroxy)phosphoryl]-2-[(3-phenyl-1,2-oxazol-5-yl)methyl]propanoyl}-L-alpha-glutamyl-L-al pha-glutamine, ...
Authors:Stura, E.A, Vera, L, Beau, F, Devel, L, Cassar-Lajeunesse, E, Dive, V.
Deposit date:2012-08-24
Release date:2013-02-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.494 Å)
Cite:Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies.
J.Med.Chem., 56, 2013
4GR8
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BU of 4gr8 by Molmil
Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470C
Descriptor: CALCIUM ION, IMIDAZOLE, Macrophage metalloelastase, ...
Authors:Stura, E.A, Vera, L, Beau, F, Devel, L, Cassar-Lajeunesse, E, Dive, V.
Deposit date:2012-08-24
Release date:2013-02-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.299 Å)
Cite:Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies.
J.Med.Chem., 56, 2013

 

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