4CA8

Drosophila Angiotensin converting enzyme (AnCE) in complex with a phosphinic tripeptide FII

Summary for 4CA8

• Entry DOI: 10.2210/pdb4ca8/pdb
• Related: 4CA5 4CA6 4CA7
• Descriptor: ANGIOTENSIN-CONVERTING ENZYME, beta-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, [(2S)-2-({3-[HYDROXYL(2-PHENYL-(1R)-1-{[(BENZYLOXY)[(2S)-2-({3-[HYDROXYL(2-PHENYL-(1R)-1-CARBONYL]-AMINO}ETHYL)PHOSPHINYL]-2-[(3-PHENYLISOXAZOL-5-YL)METHYL]-1-OXO-PROPYL}AMINO)-3-(4-HYDROXY-PHENYL), ... (7 entities in total)
• Functional Keywords: hydrolase, zinc metallopeptidase, inhibitor binding
• Biological source: DROSOPHILA MELANOGASTER (FRUIT FLY)
• Total number of polymer chains: 1
• Total formula weight: 71829.34

Authors

Masuyer, G.,Akif, M.,Czarny, B.,Beau, F.,Schwager, S.L.U.,Sturrock, E.D.,Isaac, R.E.,Dive, V.,Acharya, K.R. (deposition date: 2013-10-07, release date: 2013-12-11, Last modification date: 2023-12-20)

• Primary citation: Masuyer, G.,Akif, M.,Czarny, B.,Beau, F.,Schwager, S.L.,Sturrock, E.D.,Isaac, R.E.,Dive, V.,Acharya, K.R.; Crystal Structures of Highly Specific Phosphinic Tripeptide Enantiomers in Complex with the Angiotensin-I Converting Enzyme.; FEBS J., 281:943-, 2014; PubMed: 24289879; DOI: 10.1111/FEBS.12660

Experimental method

X-RAY DIFFRACTION (1.99 Å)