4CA6

Human Angiotensin converting enzyme N-domain in complex with a phosphinic tripeptide FI

Summary for 4CA6

Entry DOI	10.2210/pdb4ca6/pdb
Related	4CA5 4CA7 4CA8
Descriptor	ANGIOTENSIN-CONVERTING ENZYME N-DOMAIN, N-{(2S)-3-[(S)-[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl]-2-[(3-phenyl-1,2-oxazol-5-yl)methyl]propanoyl}-L-tyrosine, HEXAETHYLENE GLYCOL, ... (12 entities in total)
Functional Keywords	hydrolase, zinc metallopeptidase, inhibitor binding
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	146487.41
Authors	Masuyer, G.,Akif, M.,Czarny, B.,Beau, F.,Schwager, S.L.U.,Sturrock, E.D.,Isaac, R.E.,Dive, V.,Acharya, K.R. (deposition date: 2013-10-07, release date: 2013-12-11, Last modification date: 2023-12-20)
Primary citation	Masuyer, G.,Akif, M.,Czarny, B.,Beau, F.,Schwager, S.L.,Sturrock, E.D.,Isaac, R.E.,Dive, V.,Acharya, K.R. Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme. FEBS J., 281:943-956, 2014 Cited by PubMed: 24289879 DOI: 10.1111/febs.12660 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.91 Å)

Structure validation