4CA6
Human Angiotensin converting enzyme N-domain in complex with a phosphinic tripeptide FI
Summary for 4CA6
Entry DOI | 10.2210/pdb4ca6/pdb |
Related | 4CA5 4CA7 4CA8 |
Descriptor | ANGIOTENSIN-CONVERTING ENZYME N-DOMAIN, N-{(2S)-3-[(S)-[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl]-2-[(3-phenyl-1,2-oxazol-5-yl)methyl]propanoyl}-L-tyrosine, HEXAETHYLENE GLYCOL, ... (12 entities in total) |
Functional Keywords | hydrolase, zinc metallopeptidase, inhibitor binding |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 2 |
Total formula weight | 146487.41 |
Authors | Masuyer, G.,Akif, M.,Czarny, B.,Beau, F.,Schwager, S.L.U.,Sturrock, E.D.,Isaac, R.E.,Dive, V.,Acharya, K.R. (deposition date: 2013-10-07, release date: 2013-12-11, Last modification date: 2023-12-20) |
Primary citation | Masuyer, G.,Akif, M.,Czarny, B.,Beau, F.,Schwager, S.L.,Sturrock, E.D.,Isaac, R.E.,Dive, V.,Acharya, K.R. Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme. FEBS J., 281:943-956, 2014 Cited by PubMed: 24289879DOI: 10.1111/febs.12660 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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