Author results

1H8D
  • Download 1h8d
  • View 1h8d
Molmil generated image of 1h8d
X-RAY STRUCTURE OF THE HUMAN ALPHA-THROMBIN COMPLEX WITH A TRIPEPTIDE PHOSPHONATE INHIBITOR.
Descriptor:THROMBIN, HIRUDIN I, N-[(benzyloxy)carbonyl]-beta-phenyl-D-phenylalanyl-N-{(1S,3E)-1-[dihydroxy(diphenoxy)-lambda~5~-phosphanyl]-4-methoxybut-3-en-1-yl}-L-prolinamide
Authors:Skordalakes, E., Dodson, G.G., Green, D., Deadman, J.
Deposit date:2001-02-01
Release date:2001-02-26
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Inhibition of Human Alpha-Thrombin by a Phosphonate Tripeptide Proceeds Via a Metastable Pentacoordinated Phosphorus Intermediate
J.Mol.Biol., 311, 2001
1H8I
  • Download 1h8i
  • View 1h8i
Molmil generated image of 1h8i
X-RAY CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN WITH A TRIPEPTIDE PHOSPHONATE INHIBITOR.
Descriptor:THROMBIN, HIRUDIN I, N-[(benzyloxy)carbonyl]-beta-phenyl-D-phenylalanyl-N-[(1S)-4-methoxy-1-phosphonobutyl]-L-prolinamide
Authors:Skordalakes, E., Dodson, G.G., Green, D., Deadman, J.
Deposit date:2001-02-08
Release date:2001-03-02
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Inhibition of Human Alpha-Thrombin by a Phosphonate Tripeptide Proceeds Via a Metastable Pentacoordinated Phosphorus Intermediate
J.Mol.Biol., 311, 2001
1A3B
  • Download 1a3b
  • View 1a3b
Molmil generated image of 1a3b
COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG1
Descriptor:ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), Hirudin, ...
Authors:Skordalakes, E., Elgendy, S., Dodson, G., Goodwin, C.A., Green, D., Scully, M.F., Freyssinet, J.H., Kakkar, V.V., Deadman, J.
Deposit date:1998-01-20
Release date:1998-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide.
Biochemistry, 37, 1998
1A3E
  • Download 1a3e
  • View 1a3e
Molmil generated image of 1a3e
COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG2
Descriptor:ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), Hirudin, ...
Authors:Skordalakes, E., Elgendy, S., Goodwin, C.A., Green, D., Scullly, M.F., Kakkar, V.V., Freyssinet, J.M., Dodson, G., Deadman, J.
Deposit date:1998-01-21
Release date:1998-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide.
Biochemistry, 37, 1998
1AI8
  • Download 1ai8
  • View 1ai8
Molmil generated image of 1ai8
HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH THE EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROMPG
Descriptor:ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUDIN IIIB, ...
Authors:Skordalakes, E., Dodson, G., Elgendy, S., Goodwin, C.A., Green, D., Tyrrel, R., Scully, M.F., Freyssinet, J., Kakkar, V.V., Deadman, J.
Deposit date:1997-05-01
Release date:1997-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships.
Protein Sci., 1, 1992
3L3U
  • Download 3l3u
  • View 3l3u
Molmil generated image of 3l3u
CRYSTAL STRUCTURE OF THE HIV-1 INTEGRASE CORE DOMAIN TO 1.4A
Descriptor:POL polyprotein, SULFATE ION
Authors:Wielens, J., Chalmers, D.K., Scanlon, M.J., Parker, M.W.
Deposit date:2009-12-17
Release date:2010-03-31
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site.
Febs Lett., 584, 2010
3L3V
  • Download 3l3v
  • View 3l3v
Molmil generated image of 3l3v
STRUCTURE OF HIV-1 INTEGRASE CORE DOMAIN IN COMPLEX WITH SUCROSE
Descriptor:POL polyprotein, CADMIUM ION, SULFATE ION, ...
Authors:Wielens, J., Chalmers, D.K., Scanlon, M.J., Parker, M.W.
Deposit date:2009-12-18
Release date:2010-03-31
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site
Febs Lett., 584, 2010
1AIX
  • Download 1aix
  • View 1aix
Molmil generated image of 1aix
HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROVAL
Descriptor:ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUGEN, ...
Authors:Skordalakes, E., Dodson, G., Elgendy, S., Goodwin, C.A., Green, D., Tyrrel, R., Scully, M.F., Freyssinet, J., Kakkar, V.V., Deadman, J.
Deposit date:1997-04-30
Release date:1997-10-15
Last modified:2013-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships.
Protein Sci., 1, 1992