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4G5J
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CRYSTAL STRUCTURE OF EGFR KINASE IN COMPLEX WITH BIBW2992
Descriptor:Epidermal growth factor receptor, N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide, (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
Authors:Solca, F., Dahl, G., Zoephel, A., Bader, G., Sanderson, M., Klein, C., Kraemer, O., Himmelsbach, F., Haaksma, E., Adolf, G.R.
Deposit date:2012-07-18
Release date:2012-08-29
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker.
J.Pharmacol.Exp.Ther., 343, 2012
4G5P
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CRYSTAL STRUCTURE OF EGFR KINASE T790M IN COMPLEX WITH BIBW2992
Descriptor:Epidermal growth factor receptor, N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide
Authors:Solca, F., Dahl, G., Zoephel, A., Bader, G., Sanderson, M., Klein, C., Kraemer, O., Himmelsbach, F., Haaksma, E., Adolf, G.R.
Deposit date:2012-07-18
Release date:2012-08-29
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker.
J.Pharmacol.Exp.Ther., 343, 2012
5MR4
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LIGAND-RECEPTOR COMPLEX.
Descriptor:Neurturin, GDNF family receptor alpha-2, DI(HYDROXYETHYL)ETHER, ...
Authors:Sandmark, J., Oster, L., Aagaard, A., Roth, R.G., Dahl, G.
Deposit date:2016-12-21
Release date:2018-01-17
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.
J. Biol. Chem., 293, 2018
5MR5
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LIGAND-RECEPTOR COMPLEX.
Descriptor:Neurturin, GDNF family receptor alpha-2, SULFATE ION, ...
Authors:Sandmark, J., Oster, L., Aagaard, A., Roth, R., Dahl, G.
Deposit date:2016-12-21
Release date:2018-01-17
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.
J. Biol. Chem., 293, 2018
5MR9
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LIGAND-RECEPTOR COMPLEX.
Descriptor:Neurturin
Authors:Sandmark, J., Oster, L., Aagaard, A., Roth, R.G., Dahl, G.
Deposit date:2016-12-21
Release date:2018-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure and biophysical characterisation of the human complex - a role for heparan sulfate
To Be Published
6GY0
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MPI3KD IN COMPLEX WITH AZ3
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, ~{N}-[4-methyl-5-(1-oxidanylidene-7-sulfamoyl-isoindol-5-yl)-1,3-thiazol-2-yl]ethanamide
Authors:Petersen, J.
Deposit date:2018-06-27
Release date:2019-02-06
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:A class of highly selective inhibitors bind to an active state of PI3K gamma.
Nat.Chem.Biol., 15, 2019
5NMZ
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HUMAN NEURTURIN (97-197)
Descriptor:Neurturin, GLYCEROL
Authors:Bigalke, J.M., Sandmark, J., Roth, R.
Deposit date:2017-04-07
Release date:2018-02-14
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.
J. Biol. Chem., 293, 2018