Author results

6FWR
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STRUCTURE OF DING IN COMPLEX WITH SSDNA
Descriptor:ATP-dependent DNA helicase DinG, DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), IRON/SULFUR CLUSTER
Authors:Cheng, K., Wigley, D.B.
Deposit date:2018-03-07
Release date:2018-12-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:DNA translocation mechanism of an XPD family helicase.
Elife, 7, 2018
6FWS
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STRUCTURE OF DING IN COMPLEX WITH SSDNA AND ADPBEF
Descriptor:ATP-dependent DNA helicase DinG, DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), ...
Authors:Cheng, K., Wigley, D.
Deposit date:2018-03-07
Release date:2018-12-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:DNA translocation mechanism of an XPD family helicase.
Elife, 7, 2018
5F54
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STRUCTURE OF RECJ COMPLEXED WITH DTMP
Descriptor:Single-stranded-DNA-specific exonuclease, MANGANESE (II) ION, THYMIDINE-5'-PHOSPHATE
Authors:Hua, Y., Zhao, Y., Cheng, K.
Deposit date:2015-12-04
Release date:2016-06-15
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for DNA 5 -end resection by RecJ
Elife, 5, 2016
5F55
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STRUCTURE OF RECJ COMPLEXED WITH DNA
Descriptor:Single-stranded-DNA-specific exonuclease, DNA (5'-D(*GP*AP*TP*GP*TP*AP*CP*GP*CP*TP*AP*GP*GP*C)-3'), SULFATE ION, ...
Authors:Hua, Y., Zhao, Y., Cheng, K.
Deposit date:2015-12-04
Release date:2016-06-15
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for DNA 5 -end resection by RecJ
Elife, 5, 2016
5F56
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STRUCTURE OF RECJ COMPLEXED WITH DNA AND SSB-CT
Descriptor:Single-stranded-DNA-specific exonuclease, DNA (5'-D(*CP*TP*GP*AP*TP*GP*GP*CP*A)-3'), ALA-ASP-LEU-PRO-PHE, ...
Authors:Zhao, Y., Hua, Y., Cheng, K.
Deposit date:2015-12-04
Release date:2016-06-15
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for DNA 5 -end resection by RecJ
Elife, 5, 2016
4HQP
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ALPHA7 NICOTINIC RECEPTOR CHIMERA AND ITS COMPLEX WITH ALPHA BUNGAROTOXIN
Descriptor:Alpha7 nicotinic receptor chimera, Alpha-bungarotoxin isoform V31, N-ACETYL-D-GLUCOSAMINE
Authors:Li, S.X., Cheng, K., Gomoto, R., Bren, N., Huang, S., Sine, S., Chen, L.
Deposit date:2012-10-25
Release date:2013-07-17
Method:X-RAY DIFFRACTION (3.51 Å)
Cite:Structural principles for Alpha-neurotoxin binding to and selectivity among nicotinic receptors
To be Published
5GGM
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THE NMR STRUCTURE OF CALMODULIN IN CTAB REVERSE MICELLES
Descriptor:Calmodulin, CALCIUM ION, TERBIUM(III) ION
Authors:Xu, G., Cheng, K., Wu, Q., Liu, M., Li, C.
Deposit date:2016-06-16
Release date:2016-09-28
Method:SOLUTION NMR
Cite:The NMR structure of calmodulin in CTAB reverse micelles
To Be Published
1Q4K
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THE POLO-BOX DOMAIN OF PLK1 IN COMPLEX WITH A PHOSPHO-PEPTIDE
Descriptor:Serine/threonine-protein kinase PLK, Phospho-peptide sequence Met.Gln.Ser.pThr.Pro.Leu
Authors:Cheng, K., Lowe, E.D., Sinclair, J., Nigg, E.A., Johnson, L.N.
Deposit date:2003-08-04
Release date:2003-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex.
Embo J., 22, 2003
5ZOD
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CRYSTAL STRUCTURE OF HFEN1 IN APO FORM
Descriptor:Flap endonuclease 1, MAGNESIUM ION, POTASSIUM ION
Authors:Han, W., Hua, Y., Zhao, Y.
Deposit date:2018-04-13
Release date:2019-01-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1.
Nucleic Acids Res., 46, 2018
5ZOE
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CRYSTAL STRUCTURE OF D181A HFEN1 IN COMPLEX WITH DNA
Descriptor:Flap endonuclease 1, DNA (5'-D(*CP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*G)-3'), DNA (5'-D(*GP*CP*CP*CP*GP*TP*CP*C)-3'), ...
Authors:Han, W., Hua, Y., Zhao, Y.
Deposit date:2018-04-13
Release date:2019-01-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1.
Nucleic Acids Res., 46, 2018
5ZOF
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CRYSTAL STRUCTURE OF D181A/R192F HFEN1 IN COMPLEX WITH DNA
Descriptor:Flap endonuclease 1, DNA (5'-D(*CP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*G)-3'), DNA (5'-D(*GP*CP*CP*CP*GP*TP*CP*C)-3'), ...
Authors:Han, W., Hua, Y., Zhao, Y.
Deposit date:2018-04-13
Release date:2019-01-30
Method:X-RAY DIFFRACTION (2.249 Å)
Cite:Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1.
Nucleic Acids Res., 46, 2018
5ZOG
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CRYSTAL STRUCTURE OF R192F HFEN1 IN COMPLEX WITH DNA
Descriptor:Flap endonuclease 1, DNA (5'-D(*CP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(P*TP*CP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*G)-3'), ...
Authors:Han, W., Hua, Y., Zhao, Y.
Deposit date:2018-04-13
Release date:2019-01-30
Method:X-RAY DIFFRACTION (2.299 Å)
Cite:Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1.
Nucleic Acids Res., 46, 2018
2QN1
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GLYCOGEN PHOSPHORYLASE B IN COMPLEX WITH ASIATIC ACID
Descriptor:Glycogen phosphorylase, muscle form, asiatic acid
Authors:Zographos, S.E., Leonidas, D.D., Alexacou, K.-M., Hayes, J., Oikonomakos, N.G.
Deposit date:2007-07-17
Release date:2008-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies
J.Med.Chem., 51, 2008
2QN2
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GLYCOGEN PHOSPHORYLASE B IN COMPLEX WITH MASLINIC ACID
Descriptor:Glycogen phosphorylase, muscle form, maslinic acid
Authors:Zographos, S.E., Leonidas, D.D., Alexacou, K.-M., Hayes, J., Oikonomakos, N.G.
Deposit date:2007-07-17
Release date:2008-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.698 Å)
Cite:Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies
J.Med.Chem., 51, 2008
6DY7
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WDR5 IN COMPLEX WITH A WIN SITE INHIBITOR
Descriptor:WD repeat-containing protein 5, N-[3-(2,4-dichlorophenoxy)propyl]-1H-imidazol-2-amine, DIMETHYL SULFOXIDE, ...
Authors:Phan, J., Wang, F., Fesik, S.W.
Deposit date:2018-07-01
Release date:2019-03-13
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
6DYA
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WDR5 IN COMPLEX WITH A WIN SITE INHIBITOR
Descriptor:WD repeat-containing protein 5, N-[(3,5-dichlorophenyl)methyl]-3-[(1H-imidazol-1-yl)methyl]benzamide, SULFATE ION, ...
Authors:Phan, J., Wang, F., Fesik, S.W.
Deposit date:2018-07-01
Release date:2019-03-13
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
6E1Y
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DISCOVERY OF POTENT 2-ARYL-6,7-DIHYDRO-5HPYRROLO[ 1,2-A]IMIDAZOLES AS WDR5 WIN-SITE INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN
Descriptor:WD repeat-containing protein 5, N-[(1S)-1-(3-chlorophenyl)ethyl]-3-{[(4,5-dihydro-1H-imidazol-2-yl)amino]methyl}benzamide
Authors:Phan, J., Fesik, S.W.
Deposit date:2018-07-10
Release date:2019-03-13
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.219 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
6E1Z
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DISPLACEMENT OF WDR5 FROM CHROMATIN BY A PHARMACOLOGICAL WIN SITE INHIBITOR WITH PICOMOLAR AFFINITY
Descriptor:WD repeat-containing protein 5, 5-[(1H-imidazol-1-yl)methyl]furan-2-carboxylic acid
Authors:Phan, J., Fesik, S.W.
Deposit date:2018-07-10
Release date:2019-03-13
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
6E22
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DISPLACEMENT OF WDR5 FROM CHROMATIN BY A PHARMACOLOGICAL WIN SITE INHIBITOR WITH PICOMOLAR AFFINITY
Descriptor:WD repeat-containing protein 5, 3-{[(4,5-dihydro-1H-imidazol-2-yl)amino]methyl}-N-[(3,5-dimethoxyphenyl)methyl]-4-fluorobenzamide, SULFATE ION
Authors:Phan, J., Fesik, S.W.
Deposit date:2018-07-10
Release date:2019-03-13
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019
6E23
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DISPLACEMENT OF WDR5 FROM CHROMATIN BY A PHARMACOLOGICAL WIN SITE INHIBITOR WITH PICOMOLAR AFFINITY
Descriptor:WD repeat-containing protein 5, N-[(3,4-dichlorophenyl)methyl]-3-(6-fluoro-2-methylpyridin-3-yl)-5-{[(2E)-2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl]methyl}benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Phan, J., Fesik, S.W.
Deposit date:2018-07-10
Release date:2019-03-13
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Cell Rep, 26, 2019