6SER
Crystal structure of human STARD10
Summary for 6SER
| Entry DOI | 10.2210/pdb6ser/pdb |
| Descriptor | START domain-containing protein 10, PHOSPHATE ION, DI(HYDROXYETHYL)ETHER, ... (5 entities in total) |
| Functional Keywords | stard10, lipid transporter, type 2 diabetes, lipid transport |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 34063.72 |
| Authors | Cheng, K.,Wigley, D.B. (deposition date: 2019-07-30, release date: 2020-08-26, Last modification date: 2026-08-12) |
| Primary citation | Carrat, G.R.,Haythorne, E.,Tomas, A.,Haataja, L.,Muller, A.,Arvan, P.,Piunti, A.,Cheng, K.,Huang, M.,Pullen, T.J.,Georgiadou, E.,Stylianides, T.,Amirruddin, N.S.,Salem, V.,Distaso, W.,Cakebread, A.,Heesom, K.J.,Lewis, P.A.,Hodson, D.J.,Briant, L.J.,Fung, A.C.H.,Sessions, R.B.,Alpy, F.,Kong, A.P.S.,Benke, P.I.,Torta, F.,Teo, A.K.K.,Leclerc, I.,Solimena, M.,Wigley, D.B.,Rutter, G.A. The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis. Mol Metab, 40:101015-101015, 2020 Cited by PubMed Abstract: Risk alleles for type 2 diabetes at the STARD10 locus are associated with lowered STARD10 expression in the β-cell, impaired glucose-induced insulin secretion, and decreased circulating proinsulin:insulin ratios. Although likely to serve as a mediator of intracellular lipid transfer, the identity of the transported lipids and thus the pathways through which STARD10 regulates β-cell function are not understood. The aim of this study was to identify the lipids transported and affected by STARD10 in the β-cell and the role of the protein in controlling proinsulin processing and insulin granule biogenesis and maturation. PubMed: 32416313DOI: 10.1016/j.molmet.2020.101015 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.299 Å) |
Structure validation
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